Changes In Functioning Research Articles

Exploring challenges in later-life relationships: a qualitative study of the queries posted on counselling websites.

Divorce rates among individuals aged 50 and above are on the rise. Given the greater life expectancy compared to previous generations, this is an issue that is affecting an increasing number of people. Therefore, it warrants an inquiry into the challenges these individuals encounter in their intimate relationships. This study analyzed 225 relationship-related queries posted on Czech counselling websites to identify the strains and stressor patterns that older adults face in their relationships. The queries were limited to those that concerned themes and problems related to partnerships, were posted by one of the partners aged 60 or over, and were analyzed using inductive thematic analysis. Four main relationship issues were identified: infidelity and jealousy; relationship estrangement and cooling; undesirable changes in personality; and illness and somatic issues. Additionally, three recurring themes were identified that made the problems more demanding and that were specific to older age: lack of norms for relationships in that age group, absence of resources to tackle the issues, and personal calculation for Time Spent and Time Remaining. The research found that the types of problems encountered by older adults were similar to those experienced by younger individuals. However, the way these problems were perceived and processed was influenced by specific aspects of aging, such as societal expectations, available coping resources, and the perception of time. The findings also highlighted the challenges faced by older adults in terms of relationship norms, sexual functioning, and personality changes.

An examination of relationship satisfaction as a predictor of outcomes of brief couple therapy for posttraumatic stress disorder.

The pretreatment quality of intimate relationships can promote or interfere with couple therapy for posttraumatic stress disorder (PTSD) treatment response. We tested whether baseline relationship satisfaction predicted clinical and process outcomes in two dyadic treatments for PTSD. Using data from a randomized trial comparing brief cognitive behavioral conjoint therapy (bCBCT) for PTSD to PTSD family education (PFE) among 137 military veterans and their partners (N = 274, Mage = 42.3 years, 46.7% White, 81.0% male veteran partner), we examined whether baseline relationship satisfaction (Couples Satisfaction Index; CSI-32) predicted change in PTSD symptom severity (Clinician Administered PTSD Scale for DSM-5; CAPS-5), psychosocial functioning (Brief Inventory of Psychosocial Functioning; B-IPF), and relationship satisfaction at posttreatment and 6-month follow-up. We also explored associations with process outcomes (working alliance, treatment satisfaction, dropout). In both treatment conditions, neither partner's baseline CSI-32 score moderated change in veteran CAPS-5 or B-IPF score or any process variable. However, baseline CSI-32 scores moderated both partners' CSI-32 score change during bCBCT and PFE; participants who scored in the distressed range at baseline (n = 123) experienced significant improvements in relationship satisfaction, β = .199, whereas there was no change among those in the nondistressed range at baseline (n = 151), β = .025. Results suggest bCBCT and PFE are effective in improving PTSD symptoms and psychosocial functioning regardless of whether a couple is experiencing clinically significant relationship distress; further, these treatments improve relationship satisfaction for the most distressed individuals.

Concurrent changes in physical activity and physical functioning during retirement transition-a multi-trajectory analysis.

Physical activity and physical functioning have been reported to change over retirement transition, but the results have been inconsistent, and the two constructs have not been studied concurrently. The objective of this study was to examine concurrent changes in physical activity and physical functioning during transition to retirement among public sector employees, and to examine if occupation, sex, marital status, body mass index (BMI), alcohol consumption and smoking status are associated with observed different multi-trajectory paths. 3,550 participants of the Finnish Retirement and Aging study responded to an annual survey on physical activity and physical functioning (SF-36) before and after retirement. Group-based multi-trajectory analysis was used to identify clusters with dissimilar concurrent changes in physical activity and physical functioning. Multinomial regression analysis was used to describe the associations between covariates and the probability of being classified to a certain cluster. Participants were 63.4 (SD 1.4) years old, 83% women, 65% professional workers. Four trajectories of concurrent changes in physical activity and physical functioning were identified, one with decreasing physical functioning and low activity, one with increasing high activity and stable high functioning and two with fluctuating moderate physical activity and stable high functioning. Single, women, obese participants and risk-users of alcohol were more likely to be classified into group with low physical activity and declining physical functioning. Low physical activity below the level usually recommended was associated with lower physical functioning during retirement transition. These findings could be useful when planning interventions for retirees to maintain their physical functioning level.

Trajectories of emotional functioning and experienced care of relatives in the last year of life of patients with advanced cancer: A longitudinal analysis of the eQuiPe study.

Advanced cancer has a major impact on both patients and their relatives. To allow for personalized support, it is important to recognize which relatives will experience a decline in emotional functioning during the patient's last year of life, when this decline will occur, and what factors are associated with it. This study aimed to examine the trajectory of emotional functioning of relatives during that time and the characteristics associated with changes in this trajectory. A prospective, longitudinal, multicenter, observational study in patients with advanced cancer and their relatives was conducted (eQuiPe). We analyzed relatives' changes in emotional functioning in the patient's last year using the EORTC QLQ-C30 and assessed associations with sociodemographic and care characteristics using multivariable mixed-effects analysis. 409 relatives completed ≥1 questionnaires during the patient's last year of life. Mean age was 64years, 61% were female and 75% were the patient's partner. During this year, mean emotional functioning declined significantly over time from 73.9 to 64.6 (p=0.023, effect size=0.43). The type of relationship between relatives and patients (p=0.002), patient' sleep problems (p=0.033), and continuity of care (p=0.002) were significantly associated with changes in emotional functioning. Relatives' emotional functioning declined during the patient's last year of life. Support for them, especially partners and relatives of patients with sleep problems, is important. Relatives who experienced more continuity of care had a less steep decline in emotional functioning.

Dual trajectories of insomnia symptoms and BMI and their associations with cognitive functioning

Abstract Introduction Insomnia symptoms and high body mass index (BMI) are separately associated with poorer cognitive functioning. However, little is known about dual associations of sleep and obesity, and the changes in subjective cognitive functioning. We used a person-oriented approach to identify these dual trajectories and their associations with changes in subjective cognitive functioning. Methods Repeated surveys of the Helsinki Health Study (n = 2360, 79% women,40-60 years at baseline) were used to identify developmental patterns of insomnia symptoms and BMI (2000-2017) and changes in subjective cognitive functioning (2017-2022). Subjective cognitive functioning was inspected in three dimensions: memory, concentration, and learning ability problems. Latent group-based dual trajectory modeling and logistic regression analysis were used. Results Regarding dual trajectories of insomnia and BMI, three latent groups were selected for each. Insomnia symptoms defined as: stable low, decreasing and increasing symptoms; and BMI as: stable healthy weight (BMI < 25), stable overweight (BMI 25-29.9) and stable obesity (BMI ≥ 30). While BMI and insomnia symptoms can develop together, this study suggests that the higher likelihood of reporting poorer memory, concentration, and learning ability problems, is explained by insomnia symptoms at all levels of BMI. Thus, BMI was not associated with cognitive functioning, while increasing insomnia symptoms were associated with poorer perceived cognitive functioning for all measures examined (odds ratios ranged from 1.8 to 2.9, all statistically significant) Conclusions Dual development of insomnia and overweight is possible, but only insomnia seems to be associated with changes in subjective cognitive functioning at all BMI levels. A potential intervention point to prevent or postpone cognitive decline in later life starts likely years or even decades before retirement, when the risk factors emerge or start to increase. Key messages • The association between dual trajectories of insomnia symptoms and BMI and subjective cognitive decline is dominated by insomnia symptoms. • Our results showed that developmental patterns of insomnia symptoms are associated with decline in subjective cognitive functioning.

Transcranial magnetic stimulation as a feasible, non-invasive, neuromodulatory intervention in fetal alcohol spectrum disorders. A very first proof of concept

IntroductionA neurobiological feature of Fetal Alcohol Spectrum Disorder (FASD) is a global decrease in neuronal connectivity, which leads to significant impairments in everyday functionality. Non-invasive repetitive transcranial magnetic stimulation (rTMS) could potentially positively influence neuronal plasticity but has not yet been studied in FASD. The present trial addresses this gap, making it the first-ever study of rTMS in FASD. Materials and methodsThe prospective clinical trial was conducted at the LMU University Hospital Munich and enrolled eight FASD participants aged 6–16. Six sessions of 1 Hz-rTMS over the left dorsolateral prefrontal cortex were administered two times a week for three weeks consisting of 1500 pulses at 90 % of resting motor threshold in four trains of 375s. Outcome measures investigated feasibility and treatment response of rTMS on executive functions, attention/impulsivity, social-emotional regulation and quality of life (QoL) via standardized tests and the FASD parents’ app. ResultsAdherence and retention rate were 100 %. Adverse events (AEs) were mild and self-limiting, resulting in a per-session risk of 53.3 %, with local paraesthesia accounting for 54.2 % of the AEs. There were individual relevant but no significant group-level improvements in the investigated functional cerebral domains or participants' QoL. The FASD parents' app showed no significant change in participants' daily functioning or caregivers' QoL. Caregivers’ parental stress decreased significantly. ConclusionFASD is a very complex disorder that is difficult to treat. In addition, comorbidities as atypical responses to pharmacotherapies are frequent. For this reason, non-invasive, innovative therapies for children with FASD have to be developed. For the first time, rTMS was shown to be safe, tolerable, and acceptable and thus well feasible in paediatric patients with FASD. Further clinical studies with larger samples are needed to identify effective stimulation protocols and to evaluate treatment response.

Pleasure before business: emotions and age effects on daily activity scheduling

Activity scheduling represents a key process in daily life, involving the evaluation of the costs and benefits of the resources to be invested, but also a preference for when to engage in pleasant or unpleasant activities. Aging affects the evaluation processes and individual preferences due to changes in cognitive functioning and life perspectives. The present study investigated the differences between younger adults (age range 19–33) and older adults (age range 65–87) in a task assessing preferential scheduling of activities. Participants were asked to schedule thirty emotional activities (positive, negative, or neutral) within a 30-day time window, assigning one activity for each day. Results indicated that older adults, but not younger adults, planned positive activities closer in time, supporting the “positivity effect”. Also, both younger and older adults tended to postpone negative activities, scheduling them in the last days. Finally, for older adults only, negative affect was associated with the tendency to put positive activities closer in time. Present findings showed age-specific effects of emotional content on daily activity scheduling.

What Really Matters to Survivors of Acute Type A Aortic Dissection-A Survey of Patient-Reported Outcomes in the Dutch National Aortic Dissection Advocacy Group.

(1) Background: Type A acute aortic dissection (TAAAD) almost always requires emergency surgery, and postoperative complications are common. Quality assurance systems tend to measure only the hard outcomes, e.g., complications and mortality. Our aim was to assess the health-related quality of life of TAAAD survivors. (2) Methods: An anonymized, Dutch language, web-based survey was sent out to all of the participants of the 2022 Annual Meeting of the Dutch National Aortic Dissection (DNAD) advocacy group via their own representatives. The survey was divided into five sections: patient information, global satisfaction, surgery, including complications, and the recovery period. (3) Results: Ninety members of the DNAD group attended the meeting. Seventy-five (83%) participated in the survey, and the responses from 61 (81%) were available for analysis. Despite hindrances in their daily life (complications, changes in physical, cognitive, and social functioning), patients were satisfied with their treatment, and all would undergo the procedure again. In addition they requested better post-discharge guidance and communication (4) Conclusion: The emphasis lies in equipping patients with knowledge about potential outcomes and effective coping strategies. This underscores the importance of communication and expectation management, in line with established literature.

OptiCogs: feasibility of a multicomponent intervention to rehabilitate people with cognitive impairment post-stroke

BackgroundStroke is a leading cause of death and disability worldwide. Despite the prevalence and associated burden of cognitive impairment post-stroke, there is uncertainty regarding optimal cognitive rehabilitation for people post-stroke. This study aimed to assess whether a multicomponent intervention, called OptiCogs, is feasible, acceptable, and safe for people with cognitive impairment post-stroke. A secondary aim was to explore changes in cognitive function, fatigue, quality of life, physical function, and occupational performance, from pre-intervention to post-intervention.MethodsA feasibility study was conducted where people post-stroke with cognitive impairment enrolled in a 6-week multicomponent intervention. The primary outcomes recorded included response rate, recruitment rate, retention rate, adherence to the intervention protocol, adverse events, and acceptability of the intervention to people post-stroke. Secondary outcomes included (i) change in cognitive functioning using the Addenbrooke’s Cognitive Examination III, (ii) fatigue using the Fatigue Severity scale, (iii) quality of life using the Stroke Specific Quality of Life scale (iv) physical function using the patient-reported outcomes measurement information system, and (v) patient-reported occupational performance using the Canadian Occupational Performance Measure. The Consolidated Standards of Reporting Trials extension reporting guidelines were followed, for pilot and feasibility studies, to standardize the conduct and reporting of this study.ResultsThe response rate was 10.9%. Nine eligible participants were enrolled during the 4-month recruitment period, with eight participants completing the entire 6-week intervention, as well as the pre- and post-intervention outcome measures. There were no reported adverse events. Participants were satisfied with the intervention and found it acceptable overall. Results of the secondary outcomes were promising for cognitive function (ACE III, pre: 63.3 ± 23.9 to post: 69 ± 24.6), fatigue (FSS, pre: 52.5 ± 7.3 to post: 45.6 ± 7.2), quality of life (SSQoL, pre: 131.0 ± 26.3 to post: 169.9 ± 15.3), physical function (PROMIS-PF, pre: 15.5 ± 6.3 to post: 15.8 ± 5.3), and occupational performance (COPM performance, pre: 9.3 ± 2.3 to post: 22.9 ± 4.2) and COPM satisfaction, pre: 9.9 ± 2.1 to post: 22.7 ± 3.5).ConclusionPreliminary results suggest low-modest recruitment and high retention rates for the OptiCogs intervention. Changes in cognitive function, fatigue, quality of life, and self-reported occupational performance show improvement from pre- to post-intervention. These potential benefits require further testing in a larger pilot trial.Trial registrationNCT05414539.

Patient-physician agreement on function and pain is associated with long-term outcomes in sarcoma: findings from a longitudinal study.

We aimed to describe the level of agreement between patients and physicians on the ratings of daily functioning and pain in a cohort of sarcoma patients and assess how (dis)agreement and its change over time predicted patient-reported outcomes in survivorship. We performed secondary analysis of longitudinal data from a sarcoma-specialty clinic in Montreal, Canada. Demographics, clinical characteristics and patient-physician agreement were summarized descriptively. Linear mixed models were used to assess the effects of time, baseline agreement, change in agreement over time, interaction of time and change in agreement and 12-month daily functioning, quality of life, and fatigue. Data were available for 806 patients (57.7% male, x̄ = 53.3 years) who completed at least one questionnaire. Patient-physician disagreement was common on the level of function (43.4%) and pain (45.7%). Baseline physician-patient agreement was associated with better 12-month outcomes. Improvement in agreement on function over time was significantly associated with daily functioning (F(2, 212) = 3.18, p = 0.043) and quality of life (F(2, 212) = 3.17, p < 0.044). The pattern was similar though less pronounced for the agreement on pain. Our study offers novel insights into the importance of patient-physician agreement and communication's role in long-term patient-reported outcomes in sarcoma. The results emphasize the importance of mutual understanding of symptoms and patients' needs and suggest that further consultation in cases of discordance of ratings and opinions might be beneficial for optimal survivorship.

Parent psychological distress and parent-child relationships two years into the COVID-19 pandemic: Results from a Canadian cross-sectional study.

Mental health impacts of the COVID-19 pandemic have not been felt equally within populations. Parents with children living at home were early on identified as a population at heightened mental health risk, with concerns about the potential long-term impacts of the pandemic on parents' mental health, family functioning, and children's well-being. This study investigates impacts of the pandemic on parents' psychological distress, contextual sources of distress, and associations with family functioning nearly two years into the pandemic. Data were drawn from a national cross-sectional survey of adults living in Canada in November and December 2021 that was representative by age, gender, household income, and region. Parents with children < 18 years old living at home (N = 553) reported their experiences of psychological distress, pandemic-related stressors, coping mechanisms, and family functioning (changes in parent-child interactions, children's anxiety). Chi-square tests, logistic regression, and linear regression analyses examined sociodemographic inequities in parents' levels of psychological distress, sources and mitigating mechanisms of distress, and associations between psychological distress and family functioning. Nearly two years into the pandemic, parents with children at home reported nearly double pre-pandemic population estimates of moderate to severe psychological distress. Psychological distress was more frequently reported among parents with pre-existing mental health conditions, disabilities, and financial stressors. Parents with greater psychological distress reported increases in negative parent-child interactions due to the pandemic and higher anxiety among their children. This study identifies sustained negative impacts of the pandemic on parents' mental health and family functioning in Canada nearly two years into the pandemic, despite high vaccine uptake and declining infection rates. Disparities in financial stress, social support structures, and pre-existing mental health were identified as underlying sources of psychological distress. These results highlight that meaningful responses to promote mental health among parents and families must address social and structural inequities.

Sudden gains in PTSD symptoms and social functioning in cognitive processing therapy for posttraumatic stress disorder

ABSTRACT Objective: Sudden gains (SGs) are rapid symptom improvements between two consecutive therapy sessions that predict treatment outcomes. This study investigated SGs in posttraumatic stress disorder (PTSD) symptoms, interpersonal relationship functioning, and social role functioning in Cognitive Processing Therapy (CPT). Method: Participants were 121 patients and 81 therapists involved in a parent randomized controlled hybrid implementation-effectiveness trial of CPT. Descriptive analyses examined the frequency and timing of different forms of SGs. Multilevel modeling examined the impact of the three SGs on outcomes. Results: PTSD SGs occurred more often and at different sessions than SGs in facets of social functioning. Most individuals experienced only one form of SG and there were no significant clinical or demographic differences in those who had PTSD only SGs, social functioning only SGs, or both SGs. PTSD SGs and interpersonal relationship functioning SGs both predicted changes in PTSD symptoms and interpersonal difficulties over time, but not changes in social role functioning. SGs in social role functioning predicted all three forms of outcomes. Conclusions: The findings suggest that there are multiple forms of SGs in CPT beyond primary symptom changes that are predictive of patient outcomes. Clinicians should highlight various SGs that patients experience to further enhance outcomes.

Effects of distinct manure amendments on microbial diversity and activity in Chernozem and Retisol

The application of manure has the potential to enhance soil health by increasing organic matter content and stimulating dormant soil-borne microorganisms. However, this treatment also carries the risk of side effects, including the invasion and spread of manure-borne pathogens. To assess the survival of manure-borne microbes in soil and their introduction into the soil microbiome, a laboratory experiment was conducted. Fresh cattle, swine, and poultry manures were applied at a rate of 50 t/ha to two different soil types: Chernozem and Retisol. The soil samples, including both control and manure-amended soils, were incubated in microcosms for a period of 6 months. Analysis of the samples was performed prior to fertilization, as well as at 1- and 6-months intervals following manure application. The analysis involved determining the gene numbers of archaea, bacteria, and fungi, as well as examining the taxonomic and physiological profiles of the microbial communities. The response of the microbial communities in the two soils to the manure application varied. In Chernozem, there was an increase in microbial abundance, activation of archaea and bacteria, and a moderate shift in the structure of prokaryotic community. On the other hand, the microbial community in Retisol did not show significant activation due to the manure amendments, but notable changes in both community structure and functioning were observed during the experiment. It was found that more manure-borne genera survived after 6 months in Retisol compared to Chernozem. Consequently, manure amendments could pose a greater risk of microbial contamination in soils characterized by low microbial activity and abundance.

The Influence of Pubertal Development on Early Adolescent Sleep and Changes in Family Functioning.

Pubertal development has been separately linked to adolescents' sleep problems and larger family functioning, but research connecting these inter-related processes remains sparse. This study aimed to examine how pubertal status and tempo were related to early adolescents' sleep and their family functioning. Using longitudinal data from the Adolescent Brain and Cognitive Development study, the study's sample (N = 4682) was 49.2% female, was an average of 9.94 years old at baseline, and was 60.1% white. Analyses in the current study modeled the indirect associations between pubertal change and changes in family conflict via adolescent sleep duration and variability of duration. The results suggested that pubertal status and tempo predicted shorter adolescent sleep durations and greater variability in those durations, which predicted residual increases in family conflict. The findings highlight the role of adolescents' pubertal changes in their sleep and how such changes can negatively affect family functioning.

A - 32 Impact of Demographic Factors in African American (AA) Older Adults in Relation to Confrontational Naming Deficits on an Object Naming Task.

Dysnomia, or complaints of word-finding difficulties for names, places, and objects is common in patients with Alzheimer's Disease (ad). This common characteristic makes confrontational naming a fundamental component of neuropsychological assessment in aging populations. The Multilingual Naming Test (MINT) detects naming impairments at various stages of cognitive decline. However, our understanding of how performance varies based on education, is sparse. Authors evaluated the sensitivity of the MINT in predicting naming impairments in AA in relation to education levels. 842 cognitively unimpaired (CU) and 413 mild cognitive impairment (MCI) AA elders were administered the MINT as part of the National Alzheimer's Coordinating Center neuropsychological battery. The MINT consists of 32 items of ascending difficulty that participants must name spontaneously. Semantic and phonemic cues are given in the absence of immediate responses. A 5-number MEANS analysis was used to measure differences among CU and MCI stratifying by education level. Overall naming scores were consistently lower in cohorts with lower education across diagnosis. Unsurprisingly CU participants outperformed MCI counterparts. More sensitive tools are needed to detect cognitive functioning changes in individuals with lower education levels. The MINT offers a novel approach in detecting confrontational naming deficits in those at risk of developing ad, but norms accounting for scholastic attainment are necessary to accurately diagnose minority populations with varying education levels. Further research is required to validate the MINT in participants with diverse backgrounds, low literacy levels and other factors that could affect quality of formative education.

Sleep disorders contribute to the development of dementia and Alzheimer’s disease

Life is the highest form of adaptation to the environment which is based on energy metabolism. To maintain life, the neuromuscular system must constantly interact with the environment. The striatal muscles are the main energy consumer and their access to energy fuel is mainly limited by the brain’s needs. In the state of wakefulness, the brain must continuously process streams of sensory signals and respond to them with motor actions. At the same time, the brain to be efficient must memorize the sensory-movement relationships. Brain memory networking requires additional energy allocation, and due to limited systemic energy resources, the processes of memorization are completed during the sleep phase when the inactive muscular system allows allocating the energy fuel to the brain functions such as memory trace formation and the removal of the activity-dependent waste products. Both physiological processes can be completed during sleep only, and consequently, chronic sleep disorder leads to pathological changes in brain functioning and escalation of neurodegenerative processes. Consequently, sleep disorders become the main cause of dementia which is the prodrome of Alzheimer’s disease.

B - 109 Neurorehabilitation in Pediatric Acquired Brain Injuries: the Need for More Evidence Based Research.

Many children after sustaining an acquired brain injury (ABI) have noticeable changes in cognitive functioning (CF) making transitioning back to school difficult (Vanderlind et al., 2022). Neurorehabilitation helping to alleviate difficulties in CF are crucial to helping children succeed in school, however there is limited research on the effectiveness of neurorehabilitation in pediatric ABI's (Stark et al., 2020). This poster aims to highlight the current literature surrounding neurorehabilitation in pediatric ABI and recommendations for future research. Literature was obtained using PsychInfo and PubMed and searching keywords such as pediatric ABI, neurorehabilitation, and CF. Selected articles from 2000-2022 were reviewed and main findings were consolidated. Cognitive domains affected after an ABI include memory, executive functioning, and attention (Stark et al., 2020). Programs like AIM, NeuroPage, Captains Log, Cognitive Remediation Program, and MITII have been studied to test their effectiveness in alleviating these cognitive difficulties in pediatric ABI's (Linden et al., 2018, Wilson et al., 2009, Piovesana et al., 2017, Treble-Barna et al., 2016). According to the literature the only program that showed an improvement in CF was NeuroPage (Wilson et al., 2009). Research conducted on the efficacy of neurorehabilitation programs for memory, executive functioning, and attention in pediatric ABI's has shown mixed results. Due to the likelihood of children having difficulties in academic performance after an ABI, it is crucial that psychologists focus on research addressing the efficacy of interventions for these cognitive domains. Future research should focus on creating interventions that successfully target and improve CF in pediatric ABI.

B - 76 Neurobehavioral Sequela Following Hypoxic-Ischemic Brain Injury to the Bilateral Hippocampi and Globus Pallidus: a Clinical Case Study.

Hypoxic-ischemic brain injury (HIBI) occurs when there is deficient oxygen supply and blood flow to the brain. HIBI can be precipitated by various factors including drug overdose. Brain regions that have high vulnerability to HIBI include the hippocampus and basal ganglia. Even when damage is limited to these two regions, research suggests that diffuse cognitive deficits and changes in behavior-emotional functioning can be observed. This case study presents on a 29-year-old female who sustained HIBI to the bilateral hippocampi and globus pallidus secondary to an opioid overdose which required a 3-day hospitalization. The patient was discharged from the hospital on suboxone therapy and completed outpatient interventions which included physical therapy as well as speech-language therapy with cognitive rehab. Although improvements in her functional status were noted, she reported having persisting difficulties with cognition in addition to post-injury behavioral-emotional changes. As such, she was referred for neuropsychological testing and the evaluation was completed 6months after her hospitalization. Testing showed prominent memory impairments along with deficits in language, visuospatial skills, executive functioning, and attention. On questionnaires, she endorsed having concerns for depression, attention, and executive functioning in daily life whereas her mother endorsed concerns for executive functioning. The patient's neurobehavioral profile was consistent with broad ranging sequela that can be observed with HIBI. Recommendations included medication consultation for mood, compensatory cognitive strategies, and vocational rehab for individuals with neurological disabilities. Overall, this case study demonstrates the important role of neuropsychologists in the assessment and treatment of individuals recovering from HIBI.

A - 43 Examining the Utility of the Adaptive Behavior Scale-3rd Edition (ABAS-3) in Capturing Age-Related Changes in Daily Functioning for Neurodiverse Populations.

Current guidance for the assessment of cognitive decline for mild cognitive impairment or dementia lacks sufficient information for assessing neurodiverse populations (Janicki et. al, 2022), and standardized scores often have floor effects. This study investigated the utility of the Adaptive Behavior Scale-3rd Edition (ABAS-3) in characterizing age-related changes in daily functioning for individuals with autism and other intellectual and developmental disability (I/DD). Participants (20-76years old) resided in community-based residential programs (CBRPs) for individuals with I/DD. Aim 1 examined mean ABAS-3 raw scores for participants with at least 1 ABAS-3 (N = 171, autism n = 115, other I/DD n = 56). Aim 2 examined changes in ABAS-3 raw scores over 2years (N = 61, autism n = 37, other I/DD n = 24). ABAS-3 scales included "home-living" (HL), "self-care" (SC) and "health and safety" (HS). Aim 1 indicated variability within and across diagnostic groups, with lower performance for autistic versus other I/DD participants (p < 0.001, large effect size across all subscales). Aim 2 found varying patterns of loss, gain, and stable scores across timepoints. HL (autism loss 24.3%, gain 16.2%, stable 59.5%; I/DD loss 16.7%, gain 33.3%, stable 50.0%), SC (autism loss 29.7%, gain 16.2%, stable 54%; I/DD loss 12.5%, gain 33.3%, stable 54.2%), HS (autism loss 24.3%, gain 16.2%, stable 59.5%; I/DD loss 16.7%, gain 33.3%, stable 50.0%). This proof-of-concept study demonstrates feasibility in characterizing ADLs of individuals with autism and I/DD living in CBRPs. Future research will assess distal ABAS-3 raw score changes to track cognitive decline in individuals with autism and other I/DD.

Quality of life after prophylactic surgery for colorectal adenomatous polyposis.

Colorectal adenomatous polyposis is characterized by the onset of tens to thousands of adenomas in the colorectal epithelium and, if not treated, leads to a lifetime increased risk of developing colorectal cancer compared to the general population. Thus, prophylactic surgery is recommended. This study aims to investigate the quality of life of colorectal adenomatous polyposis patients following prophylactic surgery and indirectly compares these findings with those of healthy adults of the normative sample. All patients who underwent prophylactic surgery for polyposis and were in follow-up at the hereditary digestive tract tumors outpatient department of our institute were eligible for the study. The Short Form-36 questionnaire and 21 ad hoc items were used at the time of clinical evaluation. A total of 102 patients were enrolled. For the SF-36 domains, mean values ranged from 64.18 for vitality to 88.49 for physical functioning, with the highest variability for role-physical limitations; the minimum value of functioning was reached for role-physical limitations, role-emotional limitations, and social functioning. The maximum value of functioning was reached for role-emotional limitations (73.96%) and role-physical limitations (60.42%). In total, 48.96% and 90.63% of patients reported no fecal or urinary incontinence episodes, respectively; 69.79% of patients did not have problems in work/school resumption or the personal sexual sphere. Quality of life following prophylactic surgery for these patients seems to be good when indirectly compared to HP-normative samples'. Young adult patients appear to quickly manage and adapt to changes in bowel functioning. A minority of patients may experience social and sexual issues.