Changes In Flow Rate Research Articles

Lumped parameter liver simulation to predict acute haemodynamic alterations following partial resections.

Partial liver resections are routinely performed in living donor liver transplantation and to debulk tumours in liver malignancies, but surgical decisions on vessel reconstruction for adequate inflow and outflow are challenging. Pre-operative evaluation is often limited to radiological imaging, which fails to account for post-resection haemodynamic alterations. Substantial evidence suggests post-surgical increase in local volume flow rate enhances shear stress, signalling hepatic regeneration, but excessive shear stress has been postulated to result in small for size syndrome and liver failure. Predicting haemodynamic alterations throughout the liver is particularly challenging due to the dendritic architecture of the vasculature, spanning several orders of magnitude in diameter. Therefore, we developed a mathematical lumped parameter model with realistic heterogeneities capturing inflow/outflow of the human liver to simulate acute perfusion alterations following surgical resection. Our model is parametrized using clinical measurements, relies on a single free parameter and accurately captures established perfusion characteristics. We quantify acute changes in volume flow rate, flow speed and wall shear stress following variable, realistic liver resections and make comparisons with the intact liver. Our numerical model runs in minutes and can be adapted to patient-specific anatomy, providing a novel computational tool aimed at assisting pre- and intra-operative surgical decisions for liver resections.

Flexible operation of Post-combustion CO2 capture process enabled by NARX-MPC using neural network

Post-combustion CO2 capture (PCC) process is expected to serve as the role of a bridge solution during the transition from fossil-based to renewable energy, but extensive energy consumption is a significant hurdle to its widespread commercial adoption. Operating a PCC process economically often requires large operating condition changes in response to power plant load changes and time-varying energy prices. The ‘flexible’ operation requires a controller that aids in such a dynamic operating environment of the PCC process. To balance model complexity with prediction accuracy, we adopt NARX-MPC which employs a neural network-based NARX model as a prediction model for MPC. Under various dynamic operation scenarios, the proposed NARX-MPC is evaluated and compared with a linear MPC (LMPC) controller. Our observations indeed reveal that the NARX-MPC delivers significantly superior closed-loop control performance over the LMPC, especially in scenarios involving large changes in the power plant load or inlet flue gas flow rate and simultaneous changes in the flue gas flow rate and the CO2 capture rate.

Passive control of flow rate change due to the input pressure fluctuation based on microchannel deformation

Precise and controlled drug delivery is crucial in continuous infusion systems used for drug treatment, anesthesia, cancer chemotherapy, and pain management. Elastometric pumps are commonly utilized in continuous infusion systems for their ease of use and cost-effectiveness. However, the infusion accuracy is often compromised due to the fluctuating supply pressure of elastomeric pumps, requiring an additional flow regulator to stabilize the output flow rate. We, here, present a novel approach to passively control a flow rate even under the fluctuating pressure environment based on a channel deformation. The flow rate control is enabled by a flow regulator consisting of an open-end microchannel, a closed-end microchannel, and a flexible membrane in the middle. The pressure within an open-end microchannel decreases in the downstream direction, while the pressure within a closed-end microchannel remains equal to the input pressure, creating the pressure difference between the two channels. The membrane deforms in response to this pressure difference, allowing for adjustment of the output flow rate by decreasing the flow path area with the increase in the input pressure. It is found that this concept successfully works by maintaining a steady output flow rate over a target pressure range of 40–50 kPa. Fluid–structure interaction numerical simulations and theoretical analysis are used to explain the flow rate control mechanism of the device. The results show that the present approach offers a promising solution for achieving stable drug delivery in continuous drug infusion systems, addressing the limitations of conventional elastomeric pumps.

Forecasting the dynamics of oil flow rate changes using machinne learning methods

Forecasting the dynamics of oil flow rate changes using machinne learning methods

Design of Portable Noninvasive Positive Pressure Ventilator System Based on Threshold Trigger of Flow Rate Change

In order to effectively treat respiratory diseases, a non-invasive positive pressure ventilator system is designed, the overall structure design of the system is proposed, and the hardware construction is completed. The breathing state of the patient is identified by the threshold triggering method of the flow rate of change, and the calculation of the flow rate of change is realized by the least squares method. At the same time, the breathing parameters are calculated in real time according to the flow-time and pressure-time characteristic curves. In addition, CMV, CPAP, BiPAP and PSV ventilation modes are also implemented. Finally, the parameter measurement accuracy and ventilation mode setting tests are carried out. The results show that the calculation of key breathing parameters provided by the system meets the relevant standards, and supports the stable output of 4 ventilation modes at the same time, provides breathing treatment for patients, and meets the basic functional requirements of the ventilator.

River zebrafish combine behavioral plasticity and generalized morphology with specialized sensory and metabolic physiology to survive in a challenging environment

Phenotypes that allow animals to detect, weather, and predict changes efficiently are essential for survival in fluctuating environments. Some phenotypes may remain specialized to suit an environment perfectly, while others become more plastic or generalized, shifting flexibly to match current context or adopting a form that can utilize a wide range of contexts. Here, we tested the differences in behavior, morphology, sensory and metabolic physiology between wild zebrafish (Danio rerio) in highly variable fast-flowing rivers and still-water sites. We found that river zebrafish moved at higher velocities than did still-water fish, had lower oxygen demands, and responded less vigorously to small changes in flow rate, as we might expect for fish that are well-suited to high-flow environments. River zebrafish also had less streamlined bodies and were more behaviorally plastic than were still-water zebrafish, both features that may make them better-suited to a transitional lifestyle. Our results suggest that zebrafish use distinct sensory mechanisms and metabolic physiology to reduce energetic costs of living in fast-flowing water while relying on morphology and behavior to create flexible solutions to a challenging habitat. Insights on animals’ reliance on traits with different outcomes provide a framework to better understand their survival in future environmental fluctuations.

Вероятностная оценка эффективности применения метода циклического заводнения нефтяных пластов

Extraction of hard-to-recover hydrocarbons is becoming an urgent task for the entire world oil community. The development of new technologies and methods, as well as the improvement of existing ones, have become the main issue in the extraction of hydrocarbons at existing fields. The aim of the work was to develop the technology of hydrodynamic impact on the hydrocarbon deposit. The process of oil reservoirs flooding is one of the most widespread and traditional in the application of extraction of hard–to-recover oil. The most effective in terms of impact is the cyclic regime of flooding of oil reservoirs – periodic changes in fluid flow rates at injection and production wells with a phase shift of oscillations for individual groups of wells. The use of cyclic flooding in combination with an increase in the average level of injection pressures can give a significant increase in the coefficient of reservoir coverage in power. The degree of hydrodynamic connectivity of the layers along the section has a significant impact on the effectiveness of cyclic flooding. The coefficient of lithological connectivity of formations is determined by the ratio of the area of the reservoir confluence to the total area of the deposit and can characterize the hydrodynamic connectivity of formations along the section. Using the example of the D3 of the Korotkoye field, an assessment of the start-up of the wells of the PPD system was done as well as the analysis of the nature of its influence on the volume and water content of the extracted products of the D3 formation of the Korotkoye field under various injection modes using cyclic flooding. It is determined that when both injection wells are stopped for a long period, the output of the produced products decreases to 25%. The analysis of the total oil flow rate showed that in the variants with well shutdowns there is a stronger decrease in oil flow rate than in the variants with cyclic injection, in the variants with cyclic operation of the PPD system the highest indicators of accumulated oil production are achieved for a certain period.

A novel early gas kick monitoring method using the difference between downhole dual measurement points pressure and a genetic algorithm-based model

Prompt monitoring of early gas kicks is critical to drilling safety. Untimely detection or inappropriate control measures can easily lead to well-blowouts, resulting in enormous human and economic losses. Existing early gas kick monitoring methods need more functionality. They must provide solutions for qualitative detection and quantitative inversion of the annulus gas fraction. Firstly, this paper establishes a gas kick simulation model to describe the changes in annulus pressure accurately and verifies its accuracy using laboratory data. Secondly, the pattern of change in the annulus flow rate and its relationship with annulus gas fraction during gas kick are analyzed. In addition, the method for detecting gas kick and the model for calculating the annulus gas fraction are proposed. Finally, an annulus flow rate inversion method based on the difference between downhole dual measurement points pressure and a genetic algorithm is presented, the method's stability is analyzed, and the distance between two measurement points is optimized. The results indicate that a gas kick at the bottom of the well increases the annulus flow rate, which serves as a critical parameter for early gas kick detection. The method for annulus flow rate inversion is minimally affected by the accuracy of downhole pressure and temperature measurements. The gas kick monitoring method detects gas kicks 31.0 min earlier than the conventional pit gain method with an average relative error of less than 10% in the annulus gas fraction backward value. To improve the accuracy of the gas kick monitoring method, the optimal distance between two measurement points is 30 m, and the minimum annulus gas fraction is 3.85%. The combination of the early gas kick monitoring method with the downhole dual-measurement point measurement system has significant value in guiding the reduction of downhole gas kick risks and optimizing the well control scheme.

Computational modeling and simulation for endovascular embolization of cerebral arteriovenous malformations with liquid embolic agents

Endovascular embolization of arteriovenous malformations (AVMs) in the brain usually requires injecting liquid embolic agents (LEAs) to reduce blood flow through the malformation. In clinical procedures, the feeding artery into which the LEAs are injected, and the amount of LEAs needs to be carefully planned preoperatively. Computational fluid dynamics can simulate the injecting process of LEAs in nidus and evaluate the therapeutic effects of different procedures preoperatively. Applying a porous media model avoided the difficulties of geometric modeling of AVMs, and the complex vascular network structure within the nidus was reproduced. The multi-phase flow was applied to simulate the interaction between LEAs and blood. The viscosity of LEAs is determined by the concentration of its solute ethylene-vinyl alcohol copolymer (EVOH). The diffusion process of the solvent dimethyl sulfoxide (DMSO) was calculated by solving the species transport equation. The coagulation of LEAs was simulated by constructing the relationship between the concentration of EVOH and viscosity. The numerical simulation method of LEAs for injection and coagulation was tested on two patient-specific AVMs. The calculations predicted the flow direction of the LEAs in the nidus. The morphology of the injected LEAs could be well visualized by 3D rendering. Quantitative analysis was conducted, including flow rate changes at the feeding arteries and draining veins. The embolization process of AVMs with LEAs can be simulated by computational fluid dynamics (CFD) methods to show the therapeutic effects of different embolization procedure planning, the optimal treatment plan can be determined.

APPLICATIOaN OF TEMPERATURE CONTROL SYSTEMS AT THE CATALYST ACTIVATION STEP IN THE METHANOL TESTPLANT

Catalyst activation is an important step in methanol synthesis process, achieved by the reduction of CuO precursor producing Cu0 active sites. Testplant’s temperature operation shall be maintainted at 220°C in order to maximize the CuO reduction process in the catalyst activation step. A temperature control system shall be applied in methanol testplant to maintain the temperature during reduction process, due to sensitivity of reduction process to temperature variation and possibility of disturbance such as change in gas flow rate which could affects the operating temperature. Temperature control systems are tested by using step response at the desired setpoint, which is 220°C at pre-heater and reactor and 60°C at sampling line. The tests are conducted by changing the setpoint value at temperature controller and previously stable flow gas in the system (disturbance rejection). The temperature control system proved to be able to response well during the test. In the end, methanol is produced from syngas, indicating catalyst activation success.

Flow characteristics of cooling nozzle for high strength after hot rolling

To further improve the cooling strength and uniformity of hot rolled strip steel after rolling and optimize the structure and process parameters of high-strength cooling equipment, this paper combined the basic structural characteristics and characteristic parameters of high-strength cooling nozzles of hot rolled strip steel, using finite element analysis software. The effect of various pressure and structural arguments on the internal flow characteristics of high-strength cooling nozzles was studied. The results show that with the increasing of the system pressure, the flow rate at the manifold outlet also increases gradually, and the fluctuation of the jet velocity increases gradually, but the flow line trend of the internal velocity is unchanged. The change in the position of the main shunt hole can affect the change in flow rate at the nozzle outlet. However, when the pressure is greater than 0.3 MPa, the fluctuation range of the flow rate at the slot outlet tends to be larger. The relevant results provide some reference for the design of high-strength cooling equipment in hot rolling.

Effectiveness and safety of mesenchymal stem/stromal cell for radiation-induced hyposalivation and xerostomia in previous head and neck cancer patients (MESRIX-III): a study protocol for a single-centre, double-blinded, randomised, placebo-controlled, phase II study

BackgroundA predominant side effect of radiotherapy for head and neck cancer is salivary gland hypofunction and xerostomia leading to debilitating oral disorders and impaired quality of life (QoL). Intraglandular mesenchymal stem cell therapy has shown promising results as a treatment for xerostomia.MethodsThis is a randomised, double-blinded, placebo-controlled, parallel-group, prospective, single-centre trial investigating the safety, tolerability, and effectiveness of allogeneic stem cells as a treatment for radiation-induced hyposalivation and xerostomia for previous head and neck cancer patients.We will include a total of 120 patients who previously have been treated with radiotherapy for a head and neck cancer in Denmark. Participants will be randomly assigned using block randomisation to one of two parallel groups in a 1:1 ratio to receive ultrasound-guided injection of allogeneic adipose-derived mesenchymal stem cell (ASC) (n = 60) or placebo (n = 60) into the submandibular glands. Placebo will consist of CryoStor10 (BiolifeSolutions), the freeze media for ASCs containing 10% dimethyl sulfoxide (DMSO). The primary endpoint is change in unstimulated whole saliva flow rate. The secondary endpoints are change in stimulated whole saliva flow rate, QoL, and composition of saliva. Further secondary endpoints are safety and immune response (human leukocyte antigen (HLA) response) to the stem cells will be assessed. Patients are evaluated at baseline (before treatment), after 4 months, and after 12 months. All study personnel, except study personnel thawing and preparing the treatment for injection, and participants will be blinded to group assignment. Unblinded study personnel will not participate in the outcome assessment.DiscussionThe trials will investigate the efficacy and safety of ASC injection to the submandibular gland as a potential new treatment for post-radiation xerostomia. We hope the results will pave the way for a clinically relevant treatment to ameliorate patients with xerostomia, a severely hampering condition.Trial registrationThe study is approved by the Danish Data Protection Agency (protocol number P-2020-1164), the National Ethics Committee protocol number: (Protocol number: 1802872), and the Danish Medical Agency (2018-000348-24). The protocol was registered at the ClinicalTrials.gov database (NCT04776538).

Numerical Simulation of Heat Transfer Characteristics of Finned Tube Heat Exchanger at Different Flow Velocities

A heat exchanger is an important component where high-temperature hot air and normal-temperature water exchange heat. The heat exchange area of the finned tube heat exchanger is calculated by the rated working conditions. However, with the decrease of the heat storage temperature, the hot air temperature at the outlet of the thermodynamic energy storage device changes in a large range, directly affecting the heat exchange capacity and efficiency of the finned tube heat exchanger. This paper’s three-dimensional model is established. The heat exchanger of the finned tube is designed according to the temperature of the outlet section and the return section temperature of the heat storage system. The thermodynamic physical parameter property and characteristics of which heat exchanger’s finned tube in the air’s velocity range of 1∼10 m/s are simulated by fluent software. The velocity, temperature, pressure, and heat exchanger coefficient distribution characteristics at different positions along the airflow direction are obtained. The simulation results show that the mean flow velocity is 2.0 m/s and 5.0 m/s at the inlet cross-section. The average temperature difference between the inlet and outlet is 69.5 K and 100.5 K, respectively. The fin surface temperature difference between the first and eighth rows of finned tubes is 12.5 K and 14.4 K, respectively. The air pressure loss at the air channel inlet’s section and outlet’s section is 16.1 Pa and 69.4 Pa, respectively. When the inlet flow rate change from starting at 1.0 m/s and ending at 10.0 m/s, the tube’s wall coefficient of heat transfer, which is the second level of finned tubes, only increases by 1.8 times. The tube’s wall coefficient of heat transfer of the eighth level of finned tubes increases by the maximum, to 5 times the original, but the heat energy exchange capacity of which the second level of finned tubes is always the strongest.

EVALUATING CHANGES IN SALIVARY FLOW RATE, PH & MICROBIAL COUNT DURING FIXED ORTHODONTIC TREATMENT - AN IN VIVO STUDY

Aim of the study: Aim of this study is to assess the changes in salivary flow rate, salivary pH, plaque index, Streptococcus mutans, Lactobacillus, and Candida albicans in patients undergoing fixed orthodontic treatment, before and after placement of fixed orthodontic appliances. Materials and Method: In present study salivary samples from 60 patients (30 Males and 30 Females) with age group of 14-25 years would be undergoing fixed orthodontic treatment at the department of orthodontics. Salivary flow rate, pH, plaque index and microbial colony count were measured. Streptococcus mutans, Lactobacillus and Candida albicans colony counts were measured using mitis salivarius agar, rogosa agar and sabouraud dextrose agar respectively. Saliva collected for 5 mins and measured in ml/min. salivary pH measured with digital pH meter. Salivary samples obtained from the same patients at intervals of 8 weeks and 16 weeks after commencement of orthodontic treatment and evaluated for the same. Result: This study showed fixed orthodontic appliances increases salivary flow rate (p=0.0001), decreases salivary pH (p=0.03), increases plaque index (p=0.0001), also increases Streptococcus mutans, Lactobacillus and Candida albicans colony count (p=0.0003, p=0.0001and p=0.019 respectively). Independent t test reported salivary flow rate significantly increases more in male patients at 16 weeks interval (p=0.03). Conclusion: The results of this study confirmed that after placement of fixed orthodontic appliances plaque retention increases, which sequentially decrease the salivary pH and decreased salivary pH promote the growth of microbiota.

Cardiac Vagal Nerve Activity Increases During Exercise to Enhance Coronary Blood Flow.

The phrase complete vagal withdrawal is often used when discussing autonomic control of the heart during exercise. However, more recent studies have challenged this assumption. We hypothesized that cardiac vagal activity increases during exercise and maintains cardiac function via transmitters other than acetylcholine. Chronic direct recordings of cardiac vagal nerve activity, cardiac output, coronary artery blood flow, and heart rate were recorded in conscious adult sheep during whole-body treadmill exercise. Cardiac innervation of the left cardiac vagal branch was confirmed with lipophilic tracer dyes (DiO). Sheep were exercised with pharmacological blockers of acetylcholine (atropine, 250 mg), VIP (vasoactive intestinal peptide; [4Cl-D-Phe6,Leu17]VIP 25 µg), or saline control, randomized on different days. In a subset of sheep, the left cardiac vagal branch was denervated. Neural innervation from the cardiac vagal branch is seen at major cardiac ganglionic plexi, and within the fat pads associated with the coronary arteries. Directly recorded cardiac vagal nerve activity increased during exercise. Left cardiac vagal branch denervation attenuated the maximum changes in coronary artery blood flow (maximum exercise, control: 63.5±5.9 mL/min, n=8; cardiac vagal denervated: 32.7±5.6 mL/min, n=6, P=2.5×10-7), cardiac output, and heart rate during exercise. Atropine did not affect any cardiac parameters during exercise, but VIP antagonism significantly reduced coronary artery blood flow during exercise to a similar level to vagal denervation. Our study demonstrates that cardiac vagal nerve activity actually increases and is crucial for maintaining cardiac function during exercise. Furthermore, our findings show the dynamic modulation of coronary artery blood flow during exercise is mediated by VIP.

Structural Stress Intensity Analysis of Hybrid Heat Exchangers Based on Thermal Hydraulic Performance in S-CO2 Power Cycle

Abstract Hybrid heat exchangers (H2Xs) can be used for heat exchange equipment between high-temperature exhaust gas from ships and high-pressure supercritical carbon dioxide (S-CO2) from the S-CO2 power cycle. We investigate structural stress intensity characteristics of the H2Xs based on thermal-hydraulic performance. Air and S-CO2 are employed as the working fluids and the Stainless Steel 316 (SS316) as the solid substrate. The thermal-hydraulic performance and structural stress intensity characteristics of the H2Xs are conducted by Ansys Fluent and Mechanical, respectively. The results show the mechanical stress induced by pressure loading and the thermal stress induced by temperature gradient are found to be equally important sources of stress intensity. At the inlet and outlet of the H2Xs, the total stress intensity along all paths is not smooth and continuous, and there will be a significant change due to the change in the temperature gradient. The mechanical stress caused by the fluid pressure loss is almost negligible. The change in inlet mass flowrate and temperature mainly affects the stress intensity distribution of the left and right walls on the fin channel. The pressure variation of the diesel engine has little effect on the total stress intensity. Importantly, the total stress intensity of the H2X is mainly affected by the change in S-CO2 fluid pressure.

A Microfluidic Flow Sensor Based on CuO Nws Enhanced Solid-Liquid Contact Electrification for Trapping Platelets on Collagen and Its Quantification

Platelet number plays an important role in several kinds of diseases such as leukemia, hepatitis C, diabetes, COVID-19, microbial infections, etc. These diseases can result in thrombocytopenia, a condition where patients suffer from reduced platelets, thus requiring the need to frequently monitor the platelet count. Currently existing techniques are complex, costly, and time consuming. The target diseases continue to evolve urging the need to develop rapid, facile point-of-care devices with high precision. In this regard, the current study is focused on the development of a platelet quantification technique based on trapping of platelets in a microfluidic channel adhered with collagen layer, and CuO NWs grown on Cu tube integrated on both the sides of the channel. This trapping of platelets results in a change in the triboelectric output performance from solid-liquid contact electrification due to change in flow rate of platelet content in the plasma. These changes in triboelectric output are enhanced by CuO NWs due to its high surface-area-to-volume ratio. The study of flow sensing by integrating the microfluidic device with solid-liquid contact electrification has been reported for the first time. The flow sensing signal was optimized by variation in viscosity of the flowing liquid, channel geometry, flow rate, and triboelectric voltage measuring methods. The platelet rich plasma (PRP) and platelet poor plasma (PPP) were prepared and mixed in different ratios to prepare the solutions with different concentration of platelets (0% - 100%). The calibration curve for platelet quantification has shown a variation of 9 V for change in platelet concentration from 0% to 100%. The proposed device exhibited a linear response with the variation in platelet counts. The obtained results prove its potential and feasibility as a point-of-care device.

Long-Term Change in Flow Rates in Patients with Coronary Slow Flow

Introduction: Coronary slow flow (CSF) is a condition characterized by impaired blood flow rates in the coronary arteries. It can result in severe cardiovascular outcomes. There is no sufficient evidence regarding the certain etiology and reversibility of slow flow patterns and changes in frame counts with long-term management. Methods: We retrospectively enrolled 48 patients with chronic coronary syndrome and CSF who underwent a second angiography. A corrected coronary frame rate (CFR) >27 was defined as CSF. We created 3 groups according to the change in CSF status as the improved, not changed, and worsened groups. We compared the CFR and CSF status of the patients between the first and second angiographies within a median of 2.6 years. Results: We determined a nonsignificant change in cCFR in left anterior descending (LAD) artery (34.4 [18.9] vs. 31.59 [10.3], p = 0.35), circumflex (Cx) artery (42.84 [12.56] vs. 40.66 [13.2], p = 0.35), and right coronary artery (RCA) (57.80 [30.13] vs. 50.32 [19.5], p = 0.11). In the comparison of CSF status of LAD (75% vs. 63%, p = 0.27), Cx (96% vs. 83%, p = 0.09), RCA (94% vs. 94%, p = 1.0) between first and second angiographies, there was no significant change. In the comparison of the 3 groups according to the improvement of CSF status, there was no significant difference in demographic features, change in laboratory parameters, and time between the groups. Conclusion: There was no significant change in the median CFR and CSF status in the overall group between the two angiographies after 3 years.

Eulerian simulations of local liquid distribution in a Trickle Bed: Effects of flow rates and liquid properties

We performed Eulerian simulations of gas–liquid flow in a Trickle Bed Reactor (TBR) to understand contributions of gas–liquid, gas–solid and liquid–solid interaction forces (F→GL,F→GS,F→LS), capillary-pressure (F→C) and mechanical-dispersion (F→D) forces to local liquid spreading and how their contributions change with changes in flow rates and physical properties. Further, we simulated effects of these parameters on pressure drop (ΔP), overall liquid hold-up (〈εL〉) and importantly on local liquid spreading and validated the predictions using measurements. We have shown that F→LS significantly contributes to local liquid spreading, ΔP and 〈εL〉, whereas F→D contributes marginally. The modified F→LS model led to satisfactory predictions of local liquid spreading, ΔP and 〈εL〉 for a wide range of fluid flow rates and physical properties and predictions are in a satisfactory agreement with the measurements. The present work is an important step in extending the CFD model for simulating reactions and heat effects in TBRs.

Experimental investigation of hydrogen production performance of various salts with a chlor-alkali method

In this experimental study, the hydrogen production performance of aqueous solutions of NaCl, KCl, and CaCl2 salts via an electrochemical method through a chlor-alkali reactor is investigated. For this purpose, a laboratory-scale reactor consisting of anode and cathode compartments is built. The compartments of the reactor are separated by a cation exchange membrane which prevents the mixing of anolyte and catholyte solutions and also allows positive ions (Na+, K+, and Ca2+) and some water to pass through. Electrodes made of 316 stainless steel are used in the compartments of the reactor due to their economic efficiency. While the anode compartment of the reactor is fed with the aqueous solutions of NaCl, KCl, and CaCl2 salts one by one, the cathode compartment is fed with one of the diluted aqueous solutions of NaOH, KOH, and Ca(OH)2 bases depending on the type of salt used. Experiments are carried out at three different cell voltages (3, 4, and 5 V) and three different cell temperatures (30, 50, and 70 °C), and five different electrolyte flows (0.4, 0.6, 0.8, 1.0, and 1.2 g/s). Since the reactor dimensions are very small, experiments are also carried out with small changes in the electrolyte mass flow rate. It is observed that active chlorine gas causes serious contamination in the anode compartment and erosion on the electrode in this compartment. Therefore, the expected chlorine gas output from the anode compartment of the reactor is not observed. Luckily, a significant amount of hydrogen gas output is observed from the cathode compartment of the reactor. The minimum hydrogen production rate is 37.23 mL/h when the aqueous solution of CaCl2 is used with a mass flow rate of 0.4 g/s and cell voltage of 3 V at the cell temperature of 30 °C. The maximum hydrogen production rate is 437.72 mL/h when KCl salt solution is used with a mass flow rate of 1.2 g/s and cell voltage of 5 V at the cell temperature of 70 °C.