A simple method for the collection, preservation, shipment, and testing of minute amounts of dried blood for the diagnosis of Schistosomiasis is described. A drop of blood obtained from a finger puncture and collected on filter paper was extracted in saline by use of flexible tube and carpenter's vise. The extracted blood was tested by the indirect fluorescent antibody technique employing Schistosoma mansoni cercariae as antigen. The dried filter paper blood specimens were preserved at room temperature for as long as 90 days without detectable changes in antibody response. This technique is now being evaluated for field use in epidemiological surveys.