Chamber Response Research Articles

Carbon ion beam dosimetry in magnetic fields using Farmer-type ionization chambers of different radii: measurements and simulations

Objective.To investigate magnetic field effects on the dose distribution and ionization chambers response in carbon ion reference fields and determine magnetic field correction factors for chambers of different volumes.Approach.The response of six Farmer-type chambers with varying radii (1-6 mm, termed as R1-R6) was measured in magnetic fields up to 1 T in 0.1 T increments using an experimental electromagnet and compared with Monte Carlo simulations. Chamber readings were measured in the entrance region of a monoenergetic carbon ion beam of 390.75 MeV u-1. A lower energy of 200.28 MeV u-1was applied to chamber R3 for comparison. Polarity and recombination corrections were investigated for the R3 chamber. The local dose change induced by the magnetic field was calculated by Monte Carlo, which together with change of the chamber's response, was used to calculate the final magnetic field correction factors.Main results.The dependence of the chamber response on the magnetic field was non-linear and volume-dependent. Maximum changes ranged from 0.30% (R4) to 0.62% (R5) at 0.2 T. For R3, the response for the lower energy was systematically decreased by 0.2% in the range of 0.2 T to 0.7 T. No significant effect of the magnetic field on polarity and ion recombination correction was found. The maximum variation of the local dose was found to be (0.03 ± 0.08) % at 0.2 T for beam energy of 390.75 MeV u-1. Magnetic field correction factors for the different chambers ranged from 0.28% (R4) to 0.60% (R5).Significance.This study provides the first detailed analysis of chambers' response to magnetic flux densities of up to 1 T using chambers of different radii and comparison with simulations. By combining the chamber response alterations with local dose changes magnetic field correction factors were calculated for all six chambers, including the commercial Farmer-type chamber.

Development of novel ionization chambers for reference dosimetry in electron flash radiotherapy

AbstractBackgroundReference dosimetry in ultra‐high dose rate (UHDR) beamlines is significantly hindered by limitations in conventional ionization chamber design. In particular, conventional chambers suffer from severe charge collection efficiency (CCE) degradation in high dose per pulse (DPP) beams.PurposeThe aim of this study was to optimize the design and performance of parallel plate ion chambers for use in UHDR dosimetry applications, and evaluate their potential as reference class chambers for calibration purposes. Three chamber designs were produced to determine the influence of the ion chamber response on electrode separation, field strength, and collection volume on the ion chamber response under UHDR and ultra‐high dose per pulse (UHDPP) conditions.MethodsThree chambers were designed and produced: the A11‐VAR (0.2–1.0 mm electrode gap, 20 mm diameter collector), the A11‐TPP (0.3 mm electrode gap, 20 mm diameter collector), and the A30 (0.3 mm electrode gap, 5.4 mm diameter collector). The chambers underwent full characterization using an UHDR 9 MeV electron beam with individually varied beam parameters of pulse repetition frequency (PRF, 10–120 Hz), pulse width (PW, 0.5–4 µs), and pulse amplitude (0.01–9 Gy/pulse). The response of the ion chambers was evaluated as a function of the DPP, PRF, PW, dose rate, electric field strength, and electrode gap.ResultsThe chamber response was found to be dependent on DPP and PW, and these dependencies were mitigated with larger electric field strengths and smaller electrode spacing. At a constant electric field strength, we measured a larger CCE as a function of DPP for ion chambers with a smaller electrode gap in the A11‐VAR. For ion chambers with identical electrode gap (A11‐TPP and A30), higher electric field strengths were found to yield better CCE at higher DPP. A PW dependence was observed at low electric field strengths (500 V/mm) for DPP values ranging from 1 to 5 Gy at PWs ranging from 0.5 to 4 µs, but at electric field strengths of 1000 V/mm and higher, these effects become negligible.ConclusionThis study confirmed that the CCE of ion chambers depends strongly on the electrode spacing and the electric field strength, and also on the DPP and the PW of the UHDR beam. A significant finding of this study is that although chamber performance does depend on PW, the effect on the CCE becomes negligible with reduced electrode spacing and increased electric field. A CCE of ≥95% was achieved for DPPs of up to 5 Gy with no observable dependence on PW using the A30 chamber, while still achieving an acceptable performance in conventional dose rate beams, opening up the possibility for this type of chamber to be used as a reference class chamber for calibration purposes of electron FLASH beamlines.

Long-term stability of a PTW 34070 large-area parallel ionization chamber in clinical proton scanning beams.

In the modeling of beam data for proton therapy planning systems, absolute dose measurements are performed utilizing a Bragg peak chamber (BPC), which is a parallel-plate ionization chamber. The long-term stability of the BPC is crucial for ensuring accurate absolute dose measurement. The study aims to assess the long-term stability of the BPC in clinical proton pencil beam scanning delivery. The long-term stability evaluation focused on the BPC-Type 34070 (PTW Freiburg, Germany), utilizing clinical proton scanning beams from December 2022 to November 2023. Monthly investigations were conducted to evaluate the response and cross-calibration factor of the BPC and a reference chamber, employing the spread-out Bragg peak (SOBP) field. Additionally, assessments were made regarding the BPC's response to monoenergetic beams, along with an examination of the impact of polarity and ion recombination on the BPC. The response and cross-calibration factor of the BPC varied up to 1.9% and 1.8%, respectively, while the response of the reference chamber remained within a 0.5% range. The BPC's response to the mono-energetic beams varied up to 2.0% across all energies, demonstrating similar variation trends in both the SOBP field and mono-energetic beams. Furthermore, the variations in polarity and ion recombination effect remained stable within a 0.4% range throughout the year. Notably, the reproducibility of the BPC remained high for each measurement conducted, whether for the SOBP field or mono-energetic beams, with a maximum deviation observed at 0.1%. The response and cross-calibration factor of the BPC demonstrated significant variations, with maximum changes of 1.9% and 1.8%, respectively. However, the reproducibility of the BPC remained consistently high for each measurement. It is recommended that when conducting absolute dose measurements using a BPC, its response should be compared and corrected against the reference chamber for each measurement.

Cavity ionization chamber responses in the JAEA and the NMIJ high-energy photon reference fields for radiation protection

The dosimeter response should be calibrated in a reference field near the user's radiation environment. Environments around nuclear reactors and radition therapy facilities have high-energy photons with energies exceeding that of60Co gamma rays, and controlling exposure to these photons is important. The Japan Atomic Energy Agency (JAEA) and National Metrology Institute of Japan (NMIJ) have high-energy reference fields with energies above several MeV for different types of accelerators. Their reference fields have different fluence-energy distributions. In this study, the energy dependencies of the two-cavity ionization chambers, which are often used by secondary laboratories, were experimentally and computationally evaluated for each high-energy field. These results agreed well with relative expanded uncertainties (k= 2), and their capabilities for air kerma measurements in each high-energy reference field were confirmed. Therefore, the capabilities of the air-kerma measurements can be verified in the two high-energy reference fields.&#xD.

Investigations on the beam quality correction factor for ionization chambers in high-energy brachytherapy dosimetry

Objective. To enhance the investigations on MC calculated beam quality correction factors of thimble ionization chambers from high-energy brachytherapy sources and to develop reliable reference conditions in source and detector setups in water. Approach. The response of five different ionization chambers from PTW-Freiburg and Standard Imaging was investigated for irradiation by a high dose rate Ir-192 Flexisource in water. For a setup in a Beamscan water phantom, Monte Carlo simulations were performed to calculate correction factors for the chamber readings. After exact positioning of source and detector the absorbed dose rate at the TG-43 reference point at one centimeter nominal distance from the source was measured using these factors and compared to the specification of the calibration certificate. The Monte Carlo calculations were performed using the restricted cema formalism to gain further insight into the chamber response. Calculations were performed for the sensitive volume of the chambers, determined by the methods currently used in investigations of dosimetry in magnetic fields. Main results. Measured dose rates and values from the calibration certificate agreed within the combined uncertainty (k = 2) for all chambers except for one case in which the full air cavity was simulated. The chambers showed a distinct directional dependence. With the restricted cema formalism calculations it was possible to examine volume averaging and energy dependence of the perturbation factors contributing to the beam quality correction factor also differential in energy. Significance. This work determined beam quality correction factors to measure the absorbed dose rate from a brachytherapy source in terms of absorbed dose to water for a variety of ionization chambers. For the accurate dosimetry of brachytherapy sources with ionization chambers it is advisable to use correction factors based on the sensitive volume of the chambers and to take account for the directional dependence of chamber response.

37Ar source on-demand production and deployment for low-energy nuclear recoil measurement in ReD liquid Argon TPC

The search for light dark matter (< 10 GeV/c 2) has become increasingly important, since no conclusive evidence has been found in the higher dark matter (DM) mass region. In order to explore this light mass range, it is necessary to accurately model the response of the noble liquid time projection chamber (TPC) detectors, used in many experiments aimed at the direct measurement of DM, to low energy (< 1 keV) nuclear recoils (NRs). In this respect, 37Ar provides an ideal calibration source in the low-energy region due to its two low-energy peaks at 0.27 and 2.82 keV following electron capture with a 35-day half-life. We propose a method to produce 37Ar without chemical or heating treatments by using the 40Ca(n,α)37Ar reaction. This can be achieved by irradiating nano-CaO powder with a neutron source (e.g. AmBe) and allowing the produced 37Ar to diffuse into the argon used inside a double-phase TPC. By measuring the NR yields relative to those two low-energy points in the Recoil Directionality (ReD) experiment, other detectors can be cross-calibrated with the same source deployed. In this talk, the 37Ar source production, its deployment, and preliminary results will be presented.

Toward a multi-layer micro-structured detector for high-energy electron radiotherapy.

The use of electron beams has been rekindled by the advent of ultra-high-dose rate radiotherapy (FLASH) and very high energy electrons (VHEE). The need for development of novel technology for beam monitoring and dosimetry of such beams is of paramount importance prior to their clinical translation. In this work we explore the potential of a multi-layer nanoporous aerogel High-Energy-Current (HEC) detector as a dosimeter for electron beam. The detector does not suffer from radiation damage or signal saturation, making it suitable for very-high-dose-rate applications. Standard dose rates and energies are used to establish reference for FLASH and VHEE. We explore detector response to electron energy and residual range both experimentally and computationally. Multilayer HEC detectors were constructed using 1×-10× basic modules of Aluminum(Al)_aerogel(A)_Tantalum(Ta) with 10-70 µm layer thicknesses. Signals are collected from all electrodes (3-21, depending on module multiplicity) with zero external voltage bias. Measurements are acquired as a function of depth(z) in water equivalent plastic using Varian TrueBeam for energies E=6,9,12,15 MeV (SAD=105cm, 6×6 cone, 1000 MU/min). Computational simulations of identical detector geometries are performed using the 1D deterministic code CEPXS/ONEDANT. Additionally, percent-depth-doses PDD(z), measured with diode in water, are used to explore the response of HEC for various energies and residual ranges. The current measured from Ta electrodes resembles the shape of deposited charges in water and it is proportional to the derivative of the clinical PDD corrected for contribution from photon contamination. The signal is positive on the surface, and it decreases with depth reaching a negative local minimum at z=R50, before increasing again, reaching zero at about the practical range z=Rp. In contrast, the signal from Al electrodes is shaped like the electron PDD(z) shape but with lower signal at the surface and higher bremsstrahlung tail. By subtracting the signal from Ta and Al electrodes we obtained a curve resembling PDD(z,E) after Bremsstrahlung contamination correction. Multi-layer HEC sensors exhibit characteristic responses to electron beams that are unlike responses of ion chambers or diodes. Since the sensor structures are sensitive to electronic disequilibrium, high-Z electrodes give a signal proportional to the charge deposition pattern and can be modeled using the derivative of PDD(z).

The use of pencil ionization chamber with temporal readout capabilities to measure CT beam full width half maximum.

Measurement of Computed Tomography (CT) beam width is required by accrediting and regulating bodies for routine physics evaluations due to its direct correlation to patient dose. Current methods for performing CT beam width measurement require special hardware, software, and/or consumable films. Today, most 100-mm pencil chambers with a digital interface used to evaluate Computed Tomography Dose Index (CTDIvol) have a sufficiently high sampling rate to reconstruct a high-resolution dose profile for any acquisition mode. The goal of this study is to measure the CT beam width from the sampled dose profile under a single helical acquisition with the 100-mm pencil chamber used for CTDIvol measurements. The dose profiles for different scanners were measured for helical scans with varying collimation settings using a 100-mm pencil chamber placed at the isocenter and co-moving with the patient table. The measured dose profiles from the 100-mm pencil chamber were corrected for table attenuation by extracting a periodic correction function (PCF) to eliminate table interference. The corrected dose profiles were then deconvolved with the response function of the chamber to compute the beam profile. The beam width was defined by the full width half maximum (FWHM) of the resulting beam profile. Reference dose profiles were also measured using Gafchromic film for comparison. The beam widths, estimated using the innovative deconvolution method from the 100-mm pencil chamber, exhibit an average percentage difference of 1.6±1.8 when compared with measurements obtained through Gafchromic film for beam width assessment. The proposed approach to deconvolve the pencil chamber response demonstrates the potential of obtaining the CT beam width at high accuracy without the need of special hardware, software, or consumable films. This technique can improve workflow for routine performance evaluation of CT systems.

Characterization of positional accuracy of MLC using an ionization chamber array

PurposeThe purpose of this study is to characterize the positional accuracy of the multileaf collimator (MLC) using an ionization chamber array and develop an MLC quality assurance (QA) method. MethodsHalf of the volume for each ionization chamber located at the lower layer of the device was occluded by a specific leaf using the half-beam block (HBB) method, and the corresponding ionization chamber response was used as a baseline for the subsequent MLC QA study. The sensitivity of the method was assessed by introducing known leaf positional errors, varying from 0.5 to 2.5 mm in 0.5 mm increments in the positive and negative directions, into the baseline. The relative outputs of the detectors were linearly corrected according to the leaf position error recorded. The relationship between detector response variation relative to the baseline and the introduced leaf error was determined by function. The usefulness of the MLC QA technique developed in this study was verified weekly over 5 months. ResultsDuring the development of the algorithm, the maximum leaf absolute random position error was 0.3 mm. A strong linear relationship was observed between the relative output of the detector and the MLC positional error introduced, and the slope and coefficient of determination were −0.05159 and 0.99928, respectively. The mean MLC positional accuracy across all leaves for the error field and HBB baseline field over the 5-month assessment was 0.0649 ± 0.1340 mm and 0.0002± 0.0835 mm, respectively. ConclusionsThe automated MLC QA procedure we proposed has proven to be effective and robust, and satisfies the American Association of Physicists in Medicine (AAPM) Task Group Report 198 guideline criteria of ± 1 mm.

3020: Investigation of the response of cylindrical ionization chambers in magnetic field in proton beams

3020: Investigation of the response of cylindrical ionization chambers in magnetic field in proton beams

A computational- experimental model of reactor kinetic for investigating the linearity response of in-core neutron detectors of a low power research reactor

In this study, the linear response of fission chamber (FC) neutron detectors in Isfahan miniature neutron source reactor (MNSR) is investigated through experiments and calculations at different powers of the reactor. The linearity of the response of the main neutron detector in the MNSR is important due to its safety functions in reactor power control. Additionally, determining the linear response region of this detector presents a linear neutron dosimetry field even outside of the reactor core, i.e. at the outlet of external beam tubes. Moreover, it is very difficult to remove and calibrate this neutron detector that has been installed in the reactor core for a long time. For this purpose, an alternative method for measuring the linearity of the response of a neutron detector is extended by investigating the kinetic behavior of reactor. The aim of this method is to calculate the delayed neutrons population in the reactor core and compare with the FC detector response. In this method, the numerical solution method is used to solve the point kinetic equation with 15 delayed neutron groups (6 delayed neutron groups and 9 photo-neutron groups) after inserting a large negative reactivity into the MNSR core by considering temperature and xenon reactivity feedbacks during a coupling procedure. To obtain the xenon reactivity feedback, xenon concentration is calculated by coupling the 135Xe and 135I production equations and the εpPFnlPTnl parameter is obtained by an experimental method. Furthermore, the value of fission cross section (Σf) is calculated using a validated model in the Dragon code. The large reactivities are inserted at two initial power of 150 W and 30 kW to investigate the response of the main FC neutron detector in a cold xenon-free condition and by considering temperature and xenon reactivity feedbacks, respectively. The results demonstrate that the response of the MNSR FC detector is linear in the neutron flux range between 5 × 107 to 1 × 1012 n.cm−2.s−1, which is equivalent to reactor power of 1.5 W to 30 kW. This innovative method can be applied to calibrate the neutron detectors in other research and power reactors.

Calibration system correction factor for measuring the reference air kerma rate (RAKR) applied to high dose rate 192Ir sources (HDR)

The aim of this study was to use computer simulation to analyze the impact of the aluminum fixing support on the Reference Air Kerma (RAK), a physical quantity obtained in a calibration system that was experimentally developed in the Laboratory of Radiological Sciences of the University of the State of Rio de Janeiro (LCR-UERJ). Correction factors due to scattered radiation and the geometry of the 192Ir sources were also sought to be determined. The computational simulation was validated by comparing some parameters of the experimental results with the computational results. These parameters were: verification of the inverse square law of distance, determination of (RAKR), analysis of the source spectrum with and without encapsulation, and the sensitivity curve of the Sourcecheck 4PI ionization chamber response, as a function of the distance from the source along the axial axis, using the microSelectron-v2 (mSv2) and GammaMedplus (GMp) sources. Kerma was determined by activity in the Reference air, with calculated values of 1.725 × 10−3 U. Bq−1 and 1.710 × 10−3 U. Bq−1 for the ionization chamber NE 2571 and TN 30001, respectively. The expanded uncertainty for these values was 0.932% and 0.919%, respectively, for a coverage factor (k = 2). The correction factor due to the influence of the aluminum fixing support for measurements at 1 cm and 10 cm from the source was 0.978 and 0.969, respectively. The geometric correction factor of the sources was ksg = 1.005 with an expanded uncertainty of 0.7% for a coverage factor (k = 2). This value has a difference of approximately 0.2% compared to the experimental values.

Fano cavity test and investigation of the response of the Roos chamber irradiated by proton beams in perpendicular magnetic fields up to 1 T

Objective. The aim of this work is to investigate the response of the Roos chamber (type 34001) irradiated by clinical proton beams in magnetic fields. Approach. At first, a Fano test was implemented in Monte Carlo software package GATE version 9.2 (based on Geant4 version 11.0.2) using a cylindrical slab geometry in a magnetic field up to 1 T. In accordance to an experimental setup (Fuchs et al ), the magnetic field correction factors kQB⃗ of the Roos chamber were determined at different energies up to 252 MeV and magnetic field strengths up to 1 T, by separately simulating the ratios of chamber signals MQ/MQB⃗, without and with magnetic field, and the dose-conversion factors Dw,QB⃗/Dw,Q in a small cylinder of water, with and without magnetic field. Additionally, detailed simulations were carried out to understand the observed magnetic field dependence. Main results. The Fano test was passed with deviations smaller than 0.25% between 0 and 1 T. The ratios of the chamber signals show both energy and magnetic field dependence. The maximum deviation of the dose-conversion factors from unity of 0.22% was observed at the lowest investigated proton energy of 97.4 MeV and B⃗ = 1 T. The resulting kQB⃗ factors increase initially with the applied magnetic field and decrease again after reaching a maximum at around 0.5 T; except for the lowest 97.4 MeV beam that show no observable magnetic field dependence. The deviation from unity of the factors is also larger for higher proton energies, where the maximum lies at 1.0035(5), 1.0054(7) and 1.0069(7) for initial energies of E0 = 152, 223.4 and 252 MeV, respectively. Significance. Detailed Monte Carlo studies showed that the observed effect can be mainly attributed to the differences in the transport of electrons produced both outside and inside of the air cavity in the presence of a magnetic field.

SMA Wire Use in Hybrid Twisting and Bending/Extending Soft Fiber-Reinforced Actuators

Soft fiber-reinforced actuators have demonstrated significant potential across various robotics applications. However, the actuation motion in these actuators is typically limited to a single type of motion behavior, such as bending, extending, and twisting. Additionally, a combination of bending with twisting and extending with twisting can occur in fiber-reinforced actuators. This paper presents two novel hybrid actuators in which shape memory alloy (SMA) wires are used as reinforcement for pneumatic actuation, and upon electrical activation, they create a twisting motion. As a result, the hybrid soft SMA-reinforced actuators can select between twisting and bending, as well as twisting and extending. In pneumatic mode, a bending angle of 40° and a longitudinal strain of 20% were achieved for the bending/twisting and extending/twisting actuators, respectively. When the SMA wires are electrically activated by the Joule effect, the actuators achieved more than 90% of the maximum twisting angle (24°) in almost 2 s. Passive recovery, facilitated by the elastic response of the soft chamber, took approximately 10 s. The double-helical reinforcement by SMA wires not only enables twisting in both directions but also serves as an active recovery mechanism to more rapidly return the finger to the initial position (within 2 s). The resulting pneumatic–electric-driven soft actuators enhance dexterity and versatility, making them suitable for applications in walking robots, in-pipe crawling robots, and in-hand manipulation.

A Study on the Transient Response of Compressed Air Energy Storage in the Interaction between Gas Storage Chambers and Horseshoe-Shaped Tunnels in an Abandoned Coal Mine

This study focuses on the renovation and construction of compressed air energy storage chambers within abandoned coal mine roadways. The transient mechanical responses of underground gas storage chambers under a cycle are analyzed through thermal-solid coupling simulations. These simulations highlight changes in key parameters such as displacement, stress, and temperature within the chamber group during the loading and unloading processes of compressed air energy storage. It is found that within a cycle, the small circular chamber experiences the most significant deformation, with an average peak displacement of 0.24 mm, followed by the large circular chamber and horseshoe-shaped tunnels. The small circular chamber exhibits maximum tensile and compressive stresses. Therefore, special attention in engineering practice should be paid to the long-term safety and stability of small circular tunnels, and the stability of horseshoe-shaped tunnels should be also carefully considered. The findings from this study offer some insights for theoretical support and practical implementation in the planning, design, construction, and operation of high-pressure underground gas storage chambers for compressed air energy storage.

Right ventricular cardiomyocyte expansion accompanies cardiac regeneration in newborn mice after large left ventricular infarcts.

Cauterization of the root of the left coronary artery (LCA) in the neonatal heart on postnatal day 1 (P1) resulted in large, reproducible lesions of the left ventricle (LV), and an attendant marked adaptive response in the right ventricle (RV). The response of both chambers to LV myocardial infarction involved enhanced cardiomyocyte (CM) division and binucleation, as well as LV revascularization, leading to restored heart function within 7 days post surgery (7 dps). By contrast, infarction of P3 mice resulted in cardiac scarring without a significant regenerative and adaptive response of the LV and the RV, leading to subsequent heart failure and death within 7 dps. The prominent RV myocyte expansion in P1 mice involved an acute increase in pulmonary arterial pressure and a unique gene regulatory response, leading to an increase in RV mass and preserved heart function. Thus, distinct adaptive mechanisms in the RV, such as CM proliferation and RV expansion, enable marked cardiac regeneration of the infarcted LV at P1 and full functional recovery.

Clinical reference dosimetry for the 0.5 T inline rotating biplanar Linac-MR.

The world's first clinical 0.5 T inline rotating biplanar Linac-MR system is commissioned for clinical use. For reference dosimetry, unique features to device, including an SAD=120cm, bore clearance of 60cm × 110cm, as well as 0.5 T inline magnetic field, provide some challenges to applying a standard dosimetry protocol (i.e., TG-51). In this work, we propose a simple and practical clinical reference dosimetry protocol for the 0.5T biplanar Linac-MR and validated its results. Our dosimetry protocol for this system is as follows: tissue phantom ratios at 20 and 10cm are first measured and converted into %dd10x beam quality specifier using equations provided and Kalach and Rogers. The converted %dd10x is used to determine the ion chamber correction factor, using the equations in the TG-51 addendum for the Exradin A12 farmer chamber used, which is cross-calibrated with one calibrated at a standards laboratory. For a 0.5 T parallel field, magnetic field effect on chamber response is assumed to have no effect and is not explicitly corrected for. Once the ion chamber correction factor for a non-standard SAD (kQ,msr) is determined, TG-51 is performed to obtain dose at a depth of 10cm at SAD=120cm. The dosimetry protocol is repeated with the magnetic field ramped down. To validate our dosimetry protocol, Monte Carlo (EGSnrc) simulations are performed to confirm the determined kQ,msr values. MC Simulations and magnetic Field On versus Field Off measurements are performed to confirm that the magnetic field has no effect. To validate our overall dosimetry protocol, external dose audits, based on optical simulated luminescent dosimeters, thermal luminescent dosimeters, and alanine dosimeters are performed on the 0.5 T Linac-MR system. Our EGSnrc results confirm our protocol-determined kQ,msr values, as well as our assumptions about magnetic field effects (kB=1) within statistical uncertainty for the A-12 chamber. Our external dosimetry procedures also validated our overall dosimetry protocol for the 0.5 T biplanar Linac-MR hybrid. Ramping down the magnetic field has resulted in a dosimetric difference of 0.1%, well within experimental uncertainty. With the 0.5 T parallel magnetic field having minimal effect on the ion chamber response, a TPR20,10 approach to determine beam quality provides an accurate method to perform clinical dosimetry for the 0.5 T biplanar Linac-MR.

Investigation of ionization chamber perturbation factors using proton beam and Fano cavity test for the Monte Carlo simulation code PHITS.

The reference dose for clinical proton beam therapy is based on ionization chamber dosimetry. However, data on uncertainties in proton dosimetry are lacking, and multifaceted studies are required. Monte Carlo simulations are useful tools for calculating ionization chamber dosimetry in radiation fields and are sensitive to the transport algorithm parameters when particles are transported in a heterogeneous region. We aimed to evaluate the proton transport algorithm of the Particle and Heavy Ion Transport Code System (PHITS) using the Fano test. The response of the ionization chamber and beam quality correction factors were calculated using the same parameters as those in the Fano test and compared with those of other Monte Carlo codes for verification. The geometry of the Fano test consisted of a cylindrical gas-filled cavity sandwiched between two cylindrical walls. was calculated as the ratio of the absorbed dose in water to the dose in the cavity in the chamber. We compared the calculated using PHITS with that of a previous study, which was calculated using other Monte Carlo codes (Geant4, FULKA, and PENH) under similar conditions. The flight mesh, a parameter for charged particle transport, passed the Fano test within 0.15%. This was shown to be sufficiently accurate compared with that observed in previous studies. The calculated using PHITS were 1.116 ± 0.002 and 1.124 ± 0.003 for NACP-02 and PTW-30013, respectively, and the were 0.981 ± 0.008 and 1.027 ± 0.008, respectively, at 150MeV. Our results indicate that PHITS can calculate the and with high precision.

Dynamic collapse characteristics of the tunnel face induced by the shutdown of earth pressure balance shields (EPB): A 3D material point method study

The collapse of the tunnel face is a prevalent geological disaster in tunnelling. This study employs a three-dimensional (3D) material point method (MPM) to simulate the dynamic collapse process and post-failure mechanisms of the tunnel face. The specific focus is on the scenario where the auxiliary air pressure balanced shield with a partially filled chamber is shut down. To assess the suitability of the 3D MPM, numerical solutions are compared with the results from small-scale experimental tests. Subsequently, a series of large-scale numerical simulations is conducted to explore the dynamic collapse characteristics of the tunnel face induced by the shutdown of the EPB shield under various support air pressures and cutter head conditions. The temporal evolution of the accumulated soil masses in the soil chamber and ground responses under different support air pressures, cutter head types and opening ratios are discussed. In particular, the associated surface subsidence due to the tunnel face collapse is determined and compared with empirical solutions. Numerical results confirm the applicability of the 3D MPM for simulating the large-scale tunnel face collapse scenarios, spanning from small to large deformation analysis.

Experimental determination of magnetic field quality conversion factors for eleven ionization chambers in 1.5 T and 0.35 T MR-linac systems.

The static magnetic field present in magnetic resonance (MR)-guided radiotherapy systems can influence dose deposition and charged particle collection in air-filled ionization chambers. Thus, accurately quantifying the effect of the magnetic field on ionization chamber response is critical for output calibration. Formalisms for reference dosimetry in a magnetic field have been proposed, whereby a magnetic field quality conversion factor kB,Q is defined to account for the combined effects of the magnetic field on the radiation detector. Determination of kB,Q in the literature has focused on Monte Carlo simulation studies, with experimental validation limited to only a few ionization chamber models. The purpose of this study is to experimentally measure kB,Q for 11 ionization chamber models in two commercially available MR-guided radiotherapy systems: Elekta Unity and ViewRay MRIdian. Eleven ionization chamber models were characterized in this study: Exradin A12, A12S, A28, and A26, PTW T31010, T31021, and T31022, and IBA FC23-C, CC25, CC13, and CC08. The experimental method to measure kB,Q utilized cross-calibration against a reference Exradin A1SL chamber. Absorbed dose to water was measured for the reference A1SL chamber positioned parallel to the magnetic field with its centroid placed at the machine isocenter at a depth of 10cm in water for a 10 × 10cm2 field size at that depth. Output was subsequently measured with the test chamber at the same point of measurement. kB,Q for the test chamber was computed as the ratio of reference dose to test chamber output, with this procedure repeated for each chamber in each MR-guided radiotherapy system. For the high-field 1.5 T Elekta Unity system, the dependence of kB,Q on the chamber orientation relative to the magnetic field was quantified by rotating the chamber about the machine isocenter. Measured kB,Q values for our test dataset of ionization chamber models ranged from 0.991 to 1.002, and 0.995 to 1.004 for the Elekta Unity and ViewRay MRIdian, respectively, with kB,Q tending to increase as the chamber sensitive volume increased. Measured kB,Q values largely agreed within uncertainty to published Monte Carlo simulation data and available experimental data. kB,Q deviation from unity was minimized for ionization chamber orientation parallel or antiparallel to the magnetic field, with increased deviations observed at perpendicular orientations. Overall (k=1) uncertainty in the experimental determination of the magnetic field quality conversion factor, kB,Q was 0.71% and 0.72% for the Elekta Unity and ViewRay MRIdian systems, respectively. For a high-field MR-linac, the characterization of ionization chamber performance as angular orientation varied relative to the magnetic field confirmed that the ideal orientation for output calibration is parallel. For most of these chamber models, this study represents the first experimental characterization of chamber performance in clinical MR-linac beams. This is a critical step toward accurate output calibration for MR-guided radiotherapy systems and the measured kB,Q values will be an important reference data source for forthcoming MR-linac reference dosimetry protocols.