Abstract Kartini reactor in Yogyakarta is a nuclear reactor with a low thermal power of 100 kW that is mainly used for education, training, and research. For that purpose, measuring neutron flux and controlling the power are important operational parameters. The Fission Chamber (FC) type of detector is the main component in the reactor operation and safety system that measures the neutron flux in the outer reactor core. As the FC detector is placed in a fixed location, a numerical calculation model is needed to know the neutron flux in all outer core regions. In this study, the MCNPX code is used. The first step is to validate the model with experimental measurement. The objective of the present study is to obtain a validated model by comparing calculations using MCNPX with measurements using gold foil activation (Neutron Activation Analysis technique). The computational model tested showed promising results with an average difference compared to the gold foil activation method of about 23%. Further research can be done using more gold foil samples or foils from other materials to see the consistency of measurements or minimize the measurement difference.