The optimization of cyber-physical systems (CPS) parameters is researched with focusing on the integration of computation, networking, and physical processes with the Internet of Things (IoT). The use of intelligent IoT sensors is crucial for collecting real-time data, which is necessary for enhancing the efficiency, reliability, and performance of CPS. Various methods of CPS parameters optimization are analyzed and categorized into model-based approaches, data-driven approaches, and hybrid approaches. The model-based approaches rely on mathematical models to describe CPS behavior and use optimization algorithms like linear programming and evolutionary algorithms to predict system responses and optimize parameters. But, the limitations of model-based approaches are related to complex systems with uncertain or dynamic behavior. The data-driven approaches are more suitable for complex cyber-physical systems. These approaches utilize machine learning and data analytics techniques to extract patterns from sensor data, which are then used to adjust system parameters. The hybrid approaches combine elements of both model-based and data-driven methods. The method of cyber-physical system parameters optimization based on intelligent IoT sensors data processing is developed with using of distributed neural network. The optimization problem is formulated with constraints for the system parameters. The neural network mathematical model and learning algorithm are proposed. The performed research shows the importance of developing optimization methods for CPS parameters based on intelligent IoT sensor data, considering the evolving nature of IoT technology. The integrating intelligent sensors into CPS offers new opportunities for optimizing system performance but also presents challenges in data management and security that should be addressed in future.