C6H5)2P Research Articles

99mTc][Tc(N)PNP43]-Labeled RGD Peptides As New Probes for a Selective Detection of αvβ3 Integrin: Synthesis, Structure-Activity and Pharmacokinetic Studies.

New integrin-selective molecules suitable for therapeutic or imaging purposes are currently of interest in development of effective personalized medical platforms. RGDechi is a bifunctional peptide selective for integrin αvβ3. Herein, RGDechi and three truncated derivatives functionalized with a cysteine (1-4) were synthesized and labeled with the [99mTc][Tc(N)PNP43]-synthon ([PNP43 = (CH3)2P(CH2)2N(C2H4OCH3)(CH2)2P(CH3)2]) (99mTc1-4) as a basis for selective integrin recognition. The pharmacological parameters of all radiolabeled peptides were assessed along with the pharmacokinetic profiles of the most promising 99mTc1 and 99mTc2 compounds both on healthy and melanoma-bearing mice. Their metabolism and metabolite identification are also reported. 99mTc1-2 are able to discriminate between endogenously expressed integrins αvβ3 and αvβ5 and possess favorable pharmacokinetics characterized by low liver uptake and rapid elimination from nontarget tissues resulting in positive target-to-nontarget ratios. Results are encouraging; the presented construct can be considered the starting point for the development of agents for the selective detection of αvβ3 expression by SPECT.

Copolymerization kinetics of ethylene and carbon monoxide in the presence of palladium complexes

AbstractThe copolymerization kinetics of ethylene and carbon monoxide has been studied for the catalysts: Pd(C5H7O2)2‐P(C6H5)3‐p‐CH3C6H4SO3H in the medium of acetic acid (system A), and Pd(CH3COO)2‐CF3COOH ‐ (C6H5)2P(CH2)nP(C6H5)2(system B), where n=1−6, in the medium of methyl alcohol. The cationic palladium(II) ‐diphosphine complexes: (Dppp)2Pd(CF3COO)2 (I) and [(Dppp) Pd(μ‐OH)2Pd(Dppp)] (CF3COO)2 (II) have been synthesized and investigated by IR, electrospray mass spectrometry and elemental analysis methods. A comparative study of the copolymerization kinetics in the presence of these complexes and system B has been carried out.

Ortho-metalation of DPPE across a dirhodium(II,II) core. Synthesis and x-ray crystal structure of [Rh2(form)(O2CCF3){(C6H5)2P(CH2)2P(C6H5)(C6H4)}(DPPE)]CF3COO (form = N,N'-di-p-tolylformamidinate anion, DPPE = 1,2-bis(diphenylphosphino)ethane)

Ortho-metalation of DPPE across a dirhodium(II,II) core. Synthesis and x-ray crystal structure of [Rh2(form)(O2CCF3){(C6H5)2P(CH2)2P(C6H5)(C6H4)}(DPPE)]CF3COO (form = N,N'-di-p-tolylformamidinate anion, DPPE = 1,2-bis(diphenylphosphino)ethane)

Preparation and Characterization of Cobalt(III)-Dimethyldithiocarbamato Complexes Containing R2P(CH2)nPR2 (R=CH3, C6H5; n=1,2,3,4) and PR3 (R=C2H5, C6H5). Crystal Structure of [Co{(CH3)2NCS2}{(CH3)2PCH2P(CH3)2}2](BF4)2

Abstract Twelve new cobalt(III)-phosphine complexes, [Co(dtc)x{(CH3)2P(CH2)nP(CH3)}2}3−x](3−x)+ (x=1, 2; n=1,2,3), [Co(dtc)2{(C6H5)2P(CH2)nP(C6H5)2}]+ (n=1,2,3,4), and trans-[Co(dtc)2(PR3)2]+ (R=C2H5, C6H5) were prepared, where dtc denotes dimethyldithiocarbamate(1–). The molecular structure of [Co(dtc){(CH3)2PCH2P(CH3)2}2](BF4)2 was determined by X-ray analysis. Crystal data are: monoclinic, space group Cc, a=15.927(4), b=11.726(2), c=14.422(7) Å, β=91.38(3)°, V=2692.6(15) Å3, Z=4, R=0.058 for 2251 reflections. The complex ion forms a distorted octahedron with the small P–Co–P (73.1(2) and 75.5(2)°) and S–Co–S (75.97(9)°) chelate angles. The mean Co–P and Co–S distances are 2.238(5) and 2.285(3) Å, respectively. On the basis of the angular overlap model(AOM) treatment, the ligand field bands were assigned and the effect of ring size of diphosphine chelates on these bands were examined. Positive eπ(P) values were necessary to satisfy the observed data, and the result indicates that the Co-dπ orbitals are destabilized by coordination of the phosphine ligand.

Hydrogenation of methyl ester of Z-α-acetamidocinnamic acid catalysed by rhodium-phosphine carboxylates

The title reaction has been studied using the in situ catalysts prepared from [Rh(COD)Cl]2, [Rh(COD)OOCCH3]2 or Rh(COD) (acac) and a series of mono- and diphosphines. The use of (+)-N-acetylphenylalanine as a chiral carboxylato ligand gave catalytic systems with low asymmetric efficiency ( optical yields from 5 to 10%). Kinetics of the hydrogenation catalysed by [Rh(COD)OOCCH3]2 + (C6H5)2P(CH2)4P(C6H5)2 or P(n-C4H9)3 (Rh : P mol.ratio = 1 : 2) is reported.

Reactions of chloro complexes of dimolybdenum(II) containing quadruple metal-metal bonds with bidentate tertiary phosphines (C6H5)2P(CH2)nP(C6H5)2 (n = 1-3) and (C6H5)2P(CH2)2As(C6H5)2 in alcohol media. Effect of ligand hydrocarbon chain length and solvent on product formation and isomerization

Les reactions du titre conduisent aux complexes de type Mo 2 Cl 4 (LL) 2 . On etudie egalement les reactions de Mo 2 Cl 4 (py) 4 et Mo 2 Cl 4 (P(n-Pr) 3 ) 4 avec dppe et dppp

Ein Ylidkomplex des Rutheniums mit drei-und viergliedrigen Metallocyclen / An Ylide Complex of Ruthenium with Three-and Four-Membered Metallocycles

Abstract A spirometallocyclic complex of ruthenium with (CH3)2P(CH2)2, (CH3)2PCH2 and two (CH3)3P ligands (formula 5) is synthesized from (CH3)2P(CH2)2Li and trans-[(CH3)3P]4RuCl2 in the molar ratio 2:1. Two equivalents of (CH3)3P are liberated and the ionic complex trans-[(CH3)3P]4Ru[CH2P(CH3)3]Cl +Cl- is formed as a by-product. The products were characterized by analytical and spectroscopic data.

Cyclopentyl-und Cyclohexyl-dimethyl-methylen-phosphoran aus w-Haloalkyl-trimethylphosphonium-salzen. Goldkomplexe mono-und difunktioneller Ylide / Cyclopentyl-and Cyclohexyl-dimethyl-methylene-phosphoranes from w-Haloalkyl-trimethylphosphonium Salts. Gold Complexes of Mono-and Difunctional Ylides

(CH3)3 Pconvertsa,a,w-dibromopentaneand-hexane into w-bromoalkyltrimethylphos-phonium bromides,which undergo a cyclizationon treatment with NaNH2 in tetrahydro-furane to form the cyclopentyl-and cyclohexyl-dimethyl-methylenephosphoranes 4 and 5. From the bis-phosphonium salt(CH3)3P(CH2)6P(CH3)3 2⊕ 2Br⊖ the difunctional bis-ylide CH2=(CH3)2P(CH2)6P(CH3)2=CH2(7)is obtained. The ylide 4 was characterized by the crystalline metallocyclic Au(I)derivative 8.7 forms a polymeric gold complex.

Komplexchemie polyfunktioneller Liganden, 411 Synthese und Kristallstruktur von Di-μ-carbonyl-μ-bis(diphenylphosphino)-amin-tetracarbonyl-dikobalt(0) (Co-Co) · 0,5 Benzol / Complex Chemistry of Polyfunctional Ligands, 411 Synthesis and Crystal Structure of Di-µ-carbonyl-µ-bis(diphenylphosphino)amine-tetracarbonyl-dicobalt(0) (Co—Co) · 0.5 Benzene

X-ray investigations of brown crystals, formed as a by-product in the reaction of Co2(CO)8 with (C6H5)2P(CH2)2P(C6H5)2 show the existence of the complex Co2(µ-CO)2(CO)4μ-[(C6H5)2P]2NH. The triclinic unit cell (space group PĪ ) contains two complex molecules and one molecule benzene as a solvate. The ligand (C6H5)2P(CH2)2P(C6H5)2, prepared by literature methods, obviously sometimes contains some [(C6H5)2P]2NH. The compound Co2(μ-CO)2(CO)4μ-[(C6H5)2P]2NH can also be directly synthesized by the reaction of Co2(CO)8 with [(C6H5)2P]2NH.

ChemInform Abstract: NICKEL‐PHOSPHINE COMPLEX‐CATALYZED GRIGNARD COUPLING. I. CROSS‐COUPLING OF ALKYL, ARYL, AND ALKENYL GRIGNARD REAGENTS WITH ARYL AND ALKENYL HALIDES‐ GENERAL SCOPE AND LIMITATIONS

AbstractNach einfachen Verfahren, unter milden Reaktionsbedingungen reagieren Grignardverbindungen mit Halogeniden in Gegenwart der Dihalogendiphosphinnickel(II)‐Komplexe A‐C in hohen Ausbeuten und hoher Reinheit zu den entsprechenden Verbindungen.

Nickel-Phosphine Complex-Catalyzed Grignard Coupling. I. Cross-Coupling of Alkyl, Aryl, and Alkenyl Grignard Reagents with Aryl and Alkenyl Halides: General Scope and Limitations

Abstract It has been established that dihalodiphosphinenickel(II) complexes exhibit extremely high catalytic activity for selective cross-coupling of Grignard reagents with aryl and alkenyl halides. This catalytic reaction can be employed in synthetic practice for reasons of simple procedures, mild reaction conditions, high yields and high purity of the coupling products, and the wide applicability to reactions involving primary and secondary alkyl (regardless of the presence or absence of β-hydrogen (s)), aryl, and alkenyl Grignard reagents and nonfused, fused, and substituted aromatic halides and haloolefins. Limitations lie in sluggish reactions between alkyl Grignard reagents and dihaloethylenes. The most effective catalysts are [Ni{(C6H5)2P(CH2)3P(C6H5)2}Cl2] for alkyl and simple aryl Grignard reagents, [Ni{(CH3)2P(CH2)2P(CH3)2}Cl2] for alkenyl and allylic Grignard reagents and [Ni{P(C6H5)3}2-Cl2] for sterically hindered aryl Grignard reagents and halides. Great stabilizing effects of phosphine ligands on the catalytic species are demonstrated by no effect observed after aging the catalyst. Organic chlorides are generally the most suitable halide in view of the reasonable reactivities and limited side reactions. Ether is favored over tetrahydrofuran as solvent. About sixty experimental results are presented and several features are discussed.

ChemInform Abstract: UNSYMMETRICAL BIS‐PHOSPHORUS LIGANDS PART 8, SYNTHESIS OF AN OMEGA‐DIPHENYLPHOSPHINOALKYL GRIGNARD REAGENT, ITS PRECURSOR AND NOVEL DERIVATIVES

AbstractEs wird die Darstellung der Chloralkyldiphenylphosphine (V) in 75 ‐ 93%iger Ausbeute und die ihrer Oxide‐ sowie anderer Folgeprodukte (VI) und (VII) beschrieben.

ChemInform Abstract: COPPER(I)‐ALKYL BONDING IN THE DINUCLEAR COPPER(I) COMPOUND ((CH3)2P(CH2)2)2CU2 (I)

Chemischer InformationsdienstVolume 5, Issue 43 Organoelement Compounds ChemInform Abstract: COPPER(I)-ALKYL BONDING IN THE DINUCLEAR COPPER(I) COMPOUND ((CH3)2P(CH2)2)2CU2 (I) G. NARDIN, G. NARDINSearch for more papers by this authorL. RANDACCIO, L. RANDACCIOSearch for more papers by this authorE. ZANGRANDO, E. ZANGRANDOSearch for more papers by this author G. NARDIN, G. NARDINSearch for more papers by this authorL. RANDACCIO, L. RANDACCIOSearch for more papers by this authorE. ZANGRANDO, E. ZANGRANDOSearch for more papers by this author First published: October 29, 1974 https://doi.org/10.1002/chin.197443385Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume5, Issue43October 29, 1974 RelatedInformation

Unsymmetrical bis-phosphorus ligands. IV. Group VI metal carbonyl derivatives of diphenylphosphinomethyl and diphenylphosphinomethyl phosphinites, (C6H5)2P(CH2)nOP(C6H5)2, n = 1 or 2, and an unusual phosphorus chemical shift chelate effect

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnsymmetrical bis-phosphorus ligands. IV. Group VI metal carbonyl derivatives of diphenylphosphinomethyl and diphenylphosphinomethyl phosphinites, (C6H5)2P(CH2)nOP(C6H5)2, n = 1 or 2, and an unusual phosphorus chemical shift chelate effectSamuel O. Grim, William L. Briggs, Richard C. Barth, Chadwick A. Tolman, and J. P. JessonCite this: Inorg. Chem. 1974, 13, 5, 1095–1100Publication Date (Print):May 1, 1974Publication History Published online1 May 2002Published inissue 1 May 1974https://doi.org/10.1021/ic50135a017RIGHTS & PERMISSIONSArticle Views675Altmetric-Citations135LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (812 KB) Get e-Alerts Get e-Alerts

Stepwise metal chelate formation. Isolation of the intermediates (.pi.-C5H5)Fe(CO)2[(C6H5)2P(CH2)n)P(C6H5)2] (n = 1,2,3) and their reactions as ligands

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStepwise metal chelate formation. Isolation of the intermediates (.pi.-C5H5)Fe(CO)2[(C6H5)2P(CH2)n)P(C6H5)2] (n = 1,2,3) and their reactions as ligandsMadeline L. Brown, Jeffrey L. Cramer, John A. Ferguson, Thomas J. Meyer, and Neil WintertonCite this: J. Am. Chem. Soc. 1972, 94, 25, 8707–8710Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://doi.org/10.1021/ja00780a011RIGHTS & PERMISSIONSArticle Views81Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (493 KB) Get e-Alerts Get e-Alerts