Hybrid anchorage technique can effectively prevent end debonding and impede intermediate debonding of CFRP sheet in strengthened reinforced concrete (RC) beams. However, its effectiveness in the presence of bond defects at the CFRP-concrete interface is unclear. Therefore, this study conducted four-point bending tests on CFRP-strengthened RC beams, considering two factors: bond defects (with and without) and strengthening methods (externally bonded and hybrid anchorage). The results showed that bond defects can lead to premature intermediate debonding of the CFRP sheet, resulting in a 22.49% decrease in debonding load due to local stress concentration around them. Owing to the effectiveness of the hybrid anchorage method, the propagation of the intermediate debonding is significantly impeded, leading to a 4.32% and 21.61% higher in ultimate load and deflection, respectively. This is because the hybrid anchorage can control the distribution of local cracks and improve the overall stress distribution of CFRP. A finite element analysis was performed and compared against the experimental results which shows good agreement. Then, parametric analyses were conducted to further analyze the flexural behavior of the strengthened beams with bond defects. Finally, an analytical model was proposed to predict the flexural capacity of the hybrid strengthened beams with bond defects.