During the operation of pressurized water reactors, flow-induced vibration issues are commonly encountered, where control rod components vibrate due to the impact of coolant flow, leading to wear, thereby posing a threat to the safe operation of the reactor. This paper conducts a detailed numerical simulation of the flow field and force distribution inside a full-scale lower control rod guide tube based on the CFD method. The fluid–structure interaction analysis is performed to reveal the influence of cross-flow under various operating conditions on the vibration and displacement of control rods. The research subject consists of 24 control rods, one continuous guide section, and six control rod guide cards. The lower part of the guide tube has two flow holes on each surface, with one assumed to be a cross-flow inlet and the others as outlets. The results indicate that when considering the cross-flow effect at the flow holes, 90 % of the coolant flows out from other flow holes at the bottom of the guide tube, resulting in increased transverse velocity at the bottom and the presence of numerous vortices. The magnitude and location of the force exerted on the control rod by coolant impact are correlated. The control rod closest to the inlet of the flow hole experiences the greatest force, approximately 5.35 times the average at other positions. At a cross-flow velocity of 0.4 m/s and a low frequency of 10 Hz, the maximum displacement of the control rod is 0.3355 mm.