Cesarean Research Articles

Regional anaesthesia in pregnant women with cardiovascular diseases

Background. Currently in developed countries, up to 4 % of pregnant women have cardiovascular diseases, which are one of the leading causes of maternal mortality. Anesthesia method have an important role in the abdominal delivery in this category of patients. Objective. To summarize the experience of different anesthesia approaches to abdominal delivery in pregnant women with cardiovascular diseases.Materials and methods. A retrospective analysis of the use of various methods of anesthesia during abdominal delivery of pregnant women with cardiovascular diseases was performed.Results. In “Maternity Hospital № 13” and the Almazov National Medical Research Centre for the period from 2014 to 2018 2140 abdominal deliveries were carried out in pregnant women with heart diseases (1450 and 690, respectively). In the Maternity Hospital №13 1374 (94.8 %) of abdominal deliveries were performed under regional anesthesia, 76 (5.2 %) under general anesthesia. In Almazov National Medical Research Centre 513 (74.3 %) of abdominal deliveries were performed under regional anesthesia, 177 (25.7 %) under general anesthesia. The features of the hemodynamic profile of general and regional anesthesia in pregnant women with various heart disease are presented.Conclusion. In pregnant women with heart disease, up to 88 % of cesarean section are performed under regional anesthesia. General anesthesia is used for contraindications to regional anesthesia, as well as for obstetric indications. The use of advanced monitoring, methods of slow titration of local anesthetic dose and the use of vasopressors allow to avoid hemodynamic disorders in patients with concomitant heart disease.

Evaluation of prognostic value of cesarean section scar pregnancy after uterine arterial chemoembolization with cesarean section by ultrasonography

Objective To assess the clinical value of uterine curettage ultrasound in the evaluation of cesarean section scar pregnancy (CSP) after uterine arterial chemoembolization (UAE). Methods Retrospective analysis were performed in 42 patients who took uterine curettage within 24-48 hours after UAE treatment in the Second Affiliated Hospital of Harbin Medical University from January 2015 to June 2018. The ultrasonic manifestations were graded and classified before UAE. The intraoperative and postoperative complications, time of β-human chorionic gonadotrophin declined to normal limits were evaluated, and the formation of hematoma and hematoma absorption time were followed up by ultrasound. Results UAE was performed successfully in all patients. The ultrasound-guided scar pregnancy was successfully completed. The uterus was successfully retained in all patients.Among the 42 patients, 18 cases were 3 scores group, and 24 cases were 4 scores group according to the ultrasonic scoring system. Two cases were type Ⅰgroup, 25 cases were type Ⅱ group, and 15 cases were type Ⅲ group according to the ultrasonic classification. The amount of intraoperative complications, postoperative mass formation and absorption time were significantly different between 3 scores group and 4 scores group (P 0.05). Conclusions Ultrasonography has clinical application value in evaluating the prognosis of CSP treated with UAE. Ultrasonic scoring system can evaluate the efficacy and is helpful for predicting clinical outcome of CSP. Key words: Ultrasonography; Cesarean scar pregnancy; Uterine artery embolization; Curettage

Application of special nursing combined with multidirectional psychological intervention in prenatal intravenous indwelling needle

Objective To analyze the application effect of special nursing combined with multidirectional psychological intervention in prenatal intravenous indwelling needle. Methods A total of 80 cases of maternal patients with pregnancy-induced hypertension in department of obstetrics and gynecology of this hospital from January 2015 to July 2017 were selected.According to the equilibrium random mode, they were divided into the observation group and the control group, 40 cases of each group.The two groups were embedded prenatally venous indwelling needle.The control group was given the routine clinical path for nursing, while the observation group was given intravenous indwelling needle special nursing combined with multi-dimensional psychological intervention.The psychological stress status, prenatal mood, satisfaction degree and the delivery outcomes were compared between the two groups. Results After intervention, the state anxiety, trait anxiety and negative emotion scores in the observation group were lower than those in the control group, the positive emotion score was higher than that in the control group, the degree of satisfaction was better than that in the control group, the incidence rates of cesarean section and fetal distress and the rate of re-catheterization were significantly lower than those in the control group, and the differences were statistically significant(P<0.05). Conclusions For pregnant women with buried intravenous indwelling needles, special nursing combined with multi-dimensional psychological intervention can effectively improve their prenatal mood and improve their satisfaction. Key words: High quality nursing; Venous indwelling needle; Pregnant woman; Prenatal mood; Degree of satisfaction

Bir Üniversite Hastanesinde Çalışan Çocuk Sağlığı Profesyonellerinin Kendi Çocuklarını Anne Sütüyle Besleme Uygulamaları

Giriş: Sağlık uzmanlarının kişisel emzirme deneyimleri, hastalardaki emzirme konularını danışma ve yönetme konusundaki davranışları etkilemede önemlidir. Bu çalışma bir üniversite hastanesinde çalışan çocuk sağlığı profesyonellerinin kendi çocuklarını anne sütüyle besleme uygulamalarını belirlemek amacıyla yapılmıştır. Yöntem: Kesitsel tipte olan bu çalışma Temmuz 2019-Eylül 2019 tarihleri arasında Gaziantep Üniversitesi Tıp Fakültesi Eğitim Araştırma Hastanesi'nde yapılmıştır. Çocuk Sağlığı ve Hastalıkları Bölümünde çalışan 16 doktor ve 36 hemşire (toplam 52) çalışmaya alınmıştır. Veriler 17 sorudan oluşan anket formu ile yüz yüze görüşme tekniği ile toplanmıştır. Tanımlayıcı istatistikler SPSS 24.0 paket programı kullanılarak yapılmıştır.Bulgular: Bu çalışmada katılımcıların en küçük yaştaki çocuklarının 6 ay ile 17 yaş arasında ve %76,9’unun sezaryenle doğduğu bulundu. Doğum sonrası ilk bir saatte emzirilme oranı %86,5, ilk besin olarak anne sütünün verilmesi %82,7 olarak belirlendi. Çalışmada ilk altı ay sadece anne sütüyle beslenme oranı %44,2 idi. Katılımcıların çoğunluğu (%90,4) biberon, yarısı (%50) emzik kullanmıştı. Çocukların %30,8’ine ilk bir ayda, yarısından fazlasına (%59,6) altı aydan önce formül mama verildiği saptandı. İki yaşına kadar emzirilen ve yaşı iki yaşından küçük olup halen emzirilen çocukların oranı %25 idi. Anne sütüyle beslenmenin sonlandırılmasında en önemli nedenler; annenin çalışması %38,5 ve anne sütü yetersizliği %13,5 olarak belirtildi.Sonuç: Emzirmeye iyi bir başlangıç yapıldığı fakat emzirme sürecinin başarısız olduğu bulunmuştur. Annelerin çalışmasının, çocukların yarıdan fazlasına altı aydan önce formül mama verilmesinin ve biberon kullanılmasının yaygın olmasının bu durumu etkilediği düşünülmüştür. Bir kadın sağlık profesyoneli veya eşi olması durumunda da emzirme süresi boyunca bilgilendirilmeli ve desteklenmelidir.

Clinical features and maternal and infant outcomes of right-sided infective endocarditis during pregnancy: a case report and literature review

Objective To investigate the clinical features, treatment strategies, and maternal and infant outcomes of pregnancy complicated by right-sided infective endocarditis (RSIE) to provide evidence for clinical management. Methods By searching literature on RSIE during pregnancy from the databases of CNKI, Wanfang Database, VIP, CBM, PubMed, OVID, EMbase and ScienceDirect, relevant information were collected to analyze the clinical manifestations, risk factors, positions of intracardiac vegetations, results of blood culture, treatment strategies and maternal and infant outcomes of RSIE. Results A total of 15 articles were retrieved, involving 18 infected gravidas with the average age of (27.7±4.8) years and average gestational age at onset of (27.8±6.9) weeks. Fever (n=14), cough (n=12), anemia (n=8) and shortness of breath or dyspnea (n=8) were the common symptoms. Cardiac murmurs were detected on auscultation in seven cases, of which six were systolic murmurs and one was unspecified. Heart sounds of five cases were clear on auscultation without any murmurs. Nine cases were complicated by pulmonary embolism and five by heart failure. The major risk factors were congenital heart diseases (10/18) and intravenous drug abuse (6/18). Vegetations were commonly seen on the tricuspid valves (10/18), followed by the pulmonary valves (4/18). The rate of positive blood culture was high (15/16) with Staphylococcus (9/15) and Streptococcus (3/15) being the primary pathogens. Most pregnancies were timely ended by cesarean section. Apart from receiving fundamental antibiotic therapy for infective endocarditis, 11 patients underwent cardiac surgery, including vegetation removal, valve repair or replacement and surgery for congenital heart diseases, before or after pregnancy or during cesarean section based on their gestational age, condition, and cardiopulmonary function. There was no maternal death, but one neonatal death was reported due to severe asphyxia following cesarean section at 28 weeks. Maternal and neonatal outcomes were good during follow-up. Conclusions Pregnancy complicated by RSIE is rare and complex, requiring early diagnosis and individualized treatment. Adequate and full-course antibiotic therapy, appropriate surgical procedures and timely termination are of great importance for improving maternal and infant outcomes. Key words: Pregnancy complications, cardiovascular; Endocarditis, bacterial; Pregnancy outcome

Amniotic band syndrome: a case report

A case of amniotic band syndrome (ABS) was reported here. No obvious fetal abnormality was revealed by systematic ultrasound at 22+4 weeks of gestation. At 30 weeks of gestation, the pregnant woman was found to have excessive amniotic fluid and possible fetal edema according to ultrasound images and admitted to the First Affiliated Hospital of Nanjing Medical University. After admission, she received diet control to lower blood glucose and amniotic fluid reduction. The dynamic amniotic fluid index was measured by ultrasound, and the electrical fetal heart rate was monitored daily. Since 32 weeks of gestation, progressive reduction in fetal movement with sinusoidal fetal heart rate pattern was observed. An emergent cesarean section was performed due to fetal distress at a gestational age of 32+3 weeks. During the operation, a porous amniotic membrane was found, from the umbilical cord insertion of the placenta to the ankle of the left lower limb of the fetus. Amniotic band constricting left ankle of newborn and the edema of the left foot was obvious, then ABS was diagnosed. This amniotic band affected the left foot of the fetus directly, while there was not enough evidence whether the flake amniotic membrane near the umbilical cord insertion of the placenta could affect the fetus. This premature infant died of neonatal asphyxia 24 hours after birth. Key words: Amniotic band syndrome; Ultrasonography, prenatal; Abnormalities, multiple

Ketamine to Prevent PPD After Cesarean

Ketamine to Prevent PPD After Cesarean

MRI-Based Upper Abdominal Organs-at-Risk Atlas for Radiation Oncology

The purpose of our study was to provide a guide for identification and contouring of upper abdominal organs-at-risk (OARs) in the setting of online magnetic resonance imaging (MRI)-guided radiation treatment planning and delivery. After a needs assessment survey, it was determined that an upper abdominal MRI-based atlas of normal OARs would be of benefit to radiation oncologists and radiation therapists. An anonymized diagnostic 1.5T MRI from a patient with typical upper abdominal anatomy was used for atlas development. Two MRI sequences were selected for contouring, a T1-weighted gadoxetic acid contrast-enhanced MRI acquired in the hepatobiliary phase and axial fast imaging with balanced steady-state precession. Two additional clinical MRI sequences from commercial online MRI-guided radiation therapy systems were selected for contouring and were included in the final atlas. Contours from each data set were completed and reviewed by radiation oncologists, along with a radiologist who specializes in upper abdominal imaging, to generate a consensus upper abdominal MRI-based OAR atlas. A normal OAR atlas was developed, including recommendations for contouring. The atlas and contouring guidance are described, and high-resolution MRI images and contours are displayed. OARs, such as the bile duct and biliary tree, which may be better seen on MRI than on computed tomography, are highlighted. The full DICOM/DICOM-RT MRI images from both the diagnostic and clinical online MRI-guided radiation therapy systems data sets have been made freely available, for educational purposes, at econtour.org. This MRI contouring atlas for upper abdominal OARs should provide a useful reference for contouring and education. Its routine use may help to improve uniformity in contouring in radiation oncology planning and OAR dose calculation. Full DICOM/DICOM-RT images are available online and provide a valuable educational resource for upper abdominal MRI-based radiation therapy planning and delivery.

Prevalence of Early Maternal Complications of Cesarean Section and its Relationship with Body Mass Index in Fatemieh Hospital of Hamadan

Prevalence of Early Maternal Complications of Cesarean Section and its Relationship with Body Mass Index in Fatemieh Hospital of Hamadan

Clinical analysis of uterine arterial embolization combined with hysteroscopy in the treatment of cesarean scar pregnancy

Objective To investigate the clinical efficacy of uterine arterial embolization combined with hysteroscopy in the treatment of cesarean scar pregnancy. Methods From September 2016 to March 2018, 68 patients with cesarean scar pregnancy in the People's Hospital of He'nan Province were collected.According to different treatment methods, the patients were divided into observation group and control group.The observation group (42 cases) firstly received bilateral uterine artery embolization, then hysteroscopy pregnancy lesion was resected after 2-3 days.The control group (26 cases) directly received hysteroscopy endoscopic pregnancy lesion resection. Results There were 42 cases in the observation group, 2 cases(all of them III type)failed, of which 1 case was treated with laparoscopy, and 1 case was converted to transvaginal focus clearance.In the control group, 26 cases of cesarean scar pregnancy were treated directly by hysteroscopy, and 6 cases were failed(1 case of type I, 4 cases of type II, 1 case of type III), among which 3 cases were treated with uterine artery embolization.Then hysteroscopic surgery was performed in 2 cases, combined with laparoscopy for pregnancy focus debridement.One case of severe hemorrhage occurred in III type operation, which was immediately converted to open operation.The operation time, intraoperative blood loss, surgical success rate, length of hospital stay, blood β-HCG return to normal time, menstrual recovery time, postoperative vaginal bleeding, postoperative vaginal bleeding time in the observation group were (17.09±3.62)min, (32.6±5.6)mL, 95.2%(40/42), (4.76±1.63)d, (18.00±6.62)d, (30.28±4.23)d, (32.75±8.32)mL, (3.26±1.06)d, respectively, which in the control group were (49.51±3.41)min, (60.3±13.6)mL, 76.9%(20/26), (7.23±1.96)d, (22.00±6.91)d, (36.41±7.62)d, (46.23±11.73)mL, (6.42±2.45)d, respectively, the differences between the two groups were statistically significant(t=36.68, 14.09, χ2=5.189, t=5.62, 2.30, 4.27, 5.54, 7.35, all P<0.05). Conclusion Bilateral uterine artery embolization combined with hysteroscopy in the treatment of cesarean scar pregnancy has some advantages including high successful rate, short operation time, less bleeding, hospitalization time and postoperative recovery, etc.It is a safe and effective treatment especially for type I and type II scar pregnancy. Key words: Pregnancy, ectopic; Embolization, therapeutic; Uterine artery embolization; Hysteroscopy; Cesarean section; Cicatrix; Obstetric surgical procedures

Cesarean section delivery and the autism spectrum disorder: Risk and consequences in Bangladesh

Long-term health problems such as an elevated rate of developing obesity and asthma; and most importantly the neurodevelopmental problem of the children born by cesarean section delivery is very likely which in turn may lead to autism or attention deficit disorder. The survival and proliferation of the infant gut microbiota in relation to the mode of delivery is noteworthy because of its ultimate impact on the psychological and neurological behavior of the children. Studies so far conducted on the detrimental long-term outcomes linked with the cesarean delivery, a great deal of evidences have been found about the gut bacterial composition acquired by the infants. The early life dysbacteriosis or the imbalance of the resident microflora may hamper the protective immunity accompanied with inflammatory diseases which is also coupled with the neurological malfunction leading to autism spectra. Therefore, the intentional delivery through the C-section needs to be reduced which is unfortunately a very common case in the underdeveloped and developing countries with lack of such technical information among the huge population. Current review focused on the impact of alteration of the infant gut microorganisms (caused by the cesarean delivery) leading to the autism spectrum disorder; and concentrated on the dissemination of such knowledge in the mass community from the public health perspective.

Right ventricular function in pregnant women with or without preeclampsia

Background Preeclamsia (PE) is a multisystem disorder that affects maternal and fetal outcomes. We aimed to assess right heart function in PE by echocardiography using conventional, tissue Doppler techniques, and 2D and 4D strain. Patients and methods This study comprised 100 pregnant women aged between 32 and 41 weeks divided into two groups: group 1 included 50 pregnant women with PE, who were compared with 50 age-matched normotensive pregnant women as a control group (group 2). They were subjected to proteinuria detection, pelviabdominal ultrasound, conventional echo, tissue Doppler imaging, and 2D and 4D speckle tracking echocardiography for measurement of right ventricular (RV) dimensions and RV systolic and diastolic function indices. Results The higher percentages of cesarean delivery, low birth weight, and need for NICU were present in group 1 compared with group 2. There were significantly increased RV dimensions in group 1 compared with group 2. TAPSE (2D and 4D), RV FAC (2D and 4D), average RV Sa, 4D-RV EF, 2D-RV strain, 4D septal strain, and 4D-RV free wall strain were significantly lower in group 1. RV MPI (PW and TDI) was higher in group 1 patients. Both tricuspid E/A and RV E/Ea were significantly higher in group 1. There was a positive correlation between proteinuria and mean arterial pressure, 2D-TAPSE, RV PW-MPI, and RV TD-MPI, whereas there was a negative correlation with 2D and 4D-RV strain, 4D RVEF, 4D-FAC, and T E/A. Conclusion Women with PE had significant RV structural and functional changes. Assessment of RV by newer echocardiographic modalities such as speckle tracking echocardiography and 4D-echocardiography can detect subtle cardiac changes that may help in early diagnosis of maternal and fetal complications.

Makat Prezentasyonunda Acil ve Elektif Sezaryenlerin Karşılaştırılması: Vaka Kontrol Çalışması

Makat Prezentasyonunda Acil ve Elektif Sezaryenlerin Karşılaştırılması: Vaka Kontrol Çalışması

Eclampsia: A five-year retrospective review in Sagamu, South-West Nigeria

Context: Eclampsia is one of the leading causes of maternal and perinatal morbidity and mortality in developing countries. This is the result of poor health-seeking behavior of pregnant women and inadequate comprehensive emergency obstetric services. This study reviewed the presentation and management of eclampsia in Sagamu over a 5-year period. Aims: This study aims to determine the prevalence, pattern of clinical presentation and fetomaternal outcomes of eclampsia. Settings and Design: This was a retrospective study conducted in Olabisi Onabanjo University Teaching Hospital Sagamu, Ogun state. Subjects and Methods: Relevant information was retrieved from case notes of all patients who presented with eclampsia from January 2014 to December 2018. Data were analyzed using SPSS version 21. Results: Out of the 4656 deliveries, there were 45 cases of eclampsia giving a prevalence of 0.97%. The modal age was 20–24 years. Majority were unbooked 41 (91.1%) and 29 (64.4%) of the women were nulliparas. Antepartum eclampsia was commonest occurring in 36 women (80%). The most common premonitory symptom was headache occurring in as high as 37 women (82.2%). Most of the patients 37 (84.4%) had an abdominal delivery. There were two maternal mortalities (4.4%) and four perinatal deaths (8.9%). There was no statistically significant association between factors such as booking status, type of eclampsia, mode of delivery and parity, and the fetal outcome (APGAR score at 1 min). Conclusions: Eclampsia is still one of the preventable causes of maternal and perinatal mortality in our environment. The prevalence of eclampsia in sagamu was 0.97%. Improved health-seeking behavior, antenatal care monitoring, and prompt diagnosis and management of preeclampsia will invariably reduce the prevalence of eclampsia.

Перекисное окисление липидов и окисленность белков плазмы крови и мембран эритроцитов матери при абдоминальном родоразрешении с использованием программы ускоренного выздоровления

Перекисное окисление липидов и окисленность белков плазмы крови и мембран эритроцитов матери при абдоминальном родоразрешении с использованием программы ускоренного выздоровления

Emergency peripartum hysterectomy at Jordan University hospital - a teaching hospital experience.

IntroductionEmergency peripartum hysterectomy (EPH) is a foremost operation and is perpetually implemented in the presence of life intimidating hemorrhage during or immediately after abdominal or vaginal deliveries. The aim of this study was to review cases managed at the Department of Gynecology and Obstetrics at Jordan University Hospital (JUH).Material and methodsAll women who underwent EPH due to any cause in the period from January 2010, to December 2017 were included in the study. Data were collected retrospectively using the patients’ files namelessly. Main measures: age, gravidity, parity, number of previous cesarean sections, previous uterine surgeries, indication for hysterectomy, complications, antepartum bleeding and the need for blood transfusion.ResultsIn total, 74 cases of EPH were managed during the study period. The incidence of EPH ranged from 0.24 to 8.7 per 1000 deliveries. EPH was found to be more common following cesarean sections than vaginal deliveries. The prime indication was abnormal placentation, uterine atony, and uterine rupture. The risk factors included previous cesarean sections, scarred uteruses, multiparity, older age group. Maternal morbidity ranged from 26.5 to 31.5% and mortality from 0 to 12.5% with a mean of 4.8%.ConclusionsEPH is the most demanding obstetric surgery performed in very tiresome circumstances of life threatening hemorrhage. The indication for EPH in recent years has changed from outdated uterine atony to abnormal placentation. Antenatal eagerness of the risk factors, engrossment of proficient obstetricians at an early stage of management and a prompt hysterectomy after adequate resuscitation would go a long way in tumbling morbidity and mortality.

Didelphys Uterus: A Reason for Recurrent Breech Presentation and Operative Abdominal Delivery

Didelphys Uterus: A Reason for Recurrent Breech Presentation and Operative Abdominal Delivery

Вторичное бесплодие, ассоциированное с нишей рубца на матке после кесарева сечения

The frequency of abdominal delivery remains high and does not tend to decrease. This may lead to an increase in the number of complications associated with cesarean section, such as uterine niche. Considering the fact that literature data on uterine form of secondary infertility in patients with niches is lacking, and taking into account our own experience and observations made during laparoscopic and hysteroscopic metroplasty, we believe that it is necessary to discuss hypothetical mechanisms underlying the effects of uterine niches on: (1) natural embryo implantation or during an IVF program; (2) embryo survival (embryotoxicity); (3) quality and survival of spermatozoa (spermatoxicity). It is also important to analyze the psychological factor that decreases fertility in these patients. Key words: infertility; assisted reproductive technologies; isthmocele; caesarean section; niche; fertility

701: The effects of antepartum depressive symptoms on post-cesarean opioid consumption

To test the hypothesis that antepartum depressive symptoms are associated with increased pain scores and opioid use during postpartum hospitalization. Retrospective cohort of English or Spanish-speaking women > 18 years who had prenatal care for a singleton gestation and delivered by cesarean (CS) at > 36 weeks within a tertiary center during 2017 where all women are screened for depression with an antenatal Edinburgh Depression Scale (EDS). Exclusions included fetal anomalies or death, sickle cell disease, substance misuse, chronic pain, and fibromyalgia. Women with no EDS scores recorded antenatally were excluded. Major depressive symptoms (MDS) were defined as a documented antenatal EDS >=12 and no MDS if EDS< 12. MDS groups were compared with Student’s t-test, Wilcoxon rank sum tests, Chi-square, and exact tests where appropriate. Multiple linear regression modeled pain by MDS status controlling for smoking and anesthesia; model for opioid use included pain as well. Of the 891 patients reviewed, 676 (76%) had documented antenatal EDS scores, and 104 (15.4%) had MDS. Women with MDS were more likely to be single, use tobacco, and have general anesthesia for CS, but were otherwise similar (Table 1). Women with MDS reported higher daily and average pain scores (Table 2). In bivariate analyses, women with MDS used more morphine milligram equivalents (MME) each day during their postpartum hospitalization, leading to a higher total MME use (121mg (60.5-214.5) vs 75mg (28.5-133.5), p< 0.001). However, when adjusted for pain, MME use was not statistically significant (p=0.15). Our study supports an association between antepartum MDS and acute pain after CS leading to increased opioid use. Given the current focus on opioid stewardship, further research into this association, exploration of tailored pain control, and determining whether treatment of antepartum MDS reduces postpartum pain, and therefore opioid use, will be of the utmost priority.View Large Image Figure ViewerDownload Hi-res image Download (PPT)

Оцінювання впливу комплексної терапії вагітних із затримкою росту плода на акушерські та перинатальні наслідки розродження

The objective: estimate efficiency of complex, neuroprotective therapy of pregnant women with fetus growth inhibition and its influence on obstetric and perinatal consequences of delivery. Materials and methods. Complex examination of 95 pregnant women in term 28–34 weeks of gestation were examined. The first group (the main group) includes 32 pregnant women with fetus growth inhibition (FGI). FGI was diagnosed according to data of ultrasonic examination. Pregnant women of this group had prescribed therapy with piracetam and thiotriazolinum (1000 mg and 250 mg consequently in 100 ml of 0.9% saline solution per day, intravenously by drop infusion) in complex with L-arginine hydrochloride (4.2%, 100 ml of solution per day intravenously by drop infusion) during 10 days and further L-arginine aspartate (5 ml, 6 times per day) during 14 days. In complex therapy pregnant women also get Flebodia (diosmin 600 mg per day) during 30 days. The second group (the comparison group) is presented by 33 pregnant women with FGI whose pregnancy follow-up and assistance in labour is provided by valid orders of Ministry of Healthcare of Ukraine. The third group (the control group) comprises 30 pregnant women without FGI. Average age of pregnant women in the first group made 25.9±1.6 years in the second group – 27.7±1.8 years and 25.8±1.0 years in the control group. According to results of anthropometric measurements of pregnant women there was not determined statistically significant difference between examined groups (p&gt;0.05). The severe somatic diseases were exclusion criterion. Variational and statistic processing of results was made using STATISTICA 13 – license standard application program packages for multidimensional statistical analysis. Results. By means of analysis of peculiarities of gestation course in the examined groups there was found that rate of miscarriage in the second group made 39.4% and it was significantly higher than values of the first group (21.8%) and the third group (16.7%). General rate of anemia of pregnant women was also the highest in the second group and made 42.4% and in the first and third groups anemia occurred almost with the same rate (31/3% and 33.3%, correspondingly). Hypertensive disorders during pregnancy and labour were diagnosed only in pregnant women of the first group (6.3%) and the second group (9.1%). In the first group premature labour rate index made 3.1% and it was 6 times lower than the same index in the second group (21.2%). Fetus distress rate in the second group (18.2%) is almost 2 times higher than the same index in the first group (9.4%) and in the third group it made 3.3%. General rate of abdominal delivery was the highest in the second group and made 45.5% and in the first group – 15.6% and 6.7% in the third group. In the second group the rate of cesarean operations under urgent indications is 4 times higher than the same index in the first group (29.5% and 6.8% correspondingly). State of newborns in the examined groups was analyzed under Apgar score. Both at the first and fifth minutes the general index under the certain score was statistically and significantly lower in the second group comparing to indices of the first and thirds groups. By means of characterizing perinatal complications there was found that considerable percentage of neonatal encephalopathy and neonatal jaundice in the second group made 33.3% and 36.4% correspondingly. In the first group their rate made 9.4% and 3.1% correspondingly. In structure of perinatal pathology prematurity had occurred in 21.2% of newborns of the second group that is 6 times higher than the same index of the first group (3.1%). Mentioned complications in the third group were not found. Based on anthropometric measurements of newborns there was revealed that average index of their weight in the second group made 2162.2±105.4 g and was statistically and significantly (р&lt;0.05) lower than the same index in the first group (2785.2±100.2 g) and the third group (2914.3±180.2 g). Conclusions. 1. Results of performed research indicate that obstetric and perinatal consequences of delivery of pregnant women with fetus growth inhibition are characterized by high rate of complications but their rate considerably prevails in the group of women who hadn’t proposed complex neuroprotective therapy. Thus in group of pregnant women with fetus growth inhibition who had proposed therapy there was found the decrease of rate of complications in labour (premature labour and fetus distress) having direct influence on rate of operative delivery under urgent indications. 2. Positive effect of proposed complex neuroprotective therapy for women with fetus growth inhibition was demonstrated by statistically significant (р&lt;0.05) prevalence of both indices under Apgar score with correspondingly adaptation processes and results of anthropometric measurements of newborns and their body mass indices. Perinatal consequences of delivery are characterized by lower level of neonatal encephalopathy rate. Key words: pregnancy, fetus growth inhibition, obstetric and perinatal complications, neuroprotective therapy.