IntroductionThyroid nodules are very frequent in our clinical practice and most of them are benign (85%). History and clinical examinationThyroid nodules are usually asymptomatic. The clinical importance of nodular thyroid disease is related to the possibility of malignancy. Their study should always include thyroid function test and the evaluation of compressive or structural symptoms. EvaluationIn all patients with a thyroid nodule, a complete history and physical examination, a serum TSH measurement and a cervical ultrasonography should be performed. Thyroid ultrasonography should evaluate the location and sonographic characteristics of all nodules. The nodule size and the pattern of sonographic features confer the risk of malignancy and aid decision-making process about whether fine needle aspiration (FNA) is indicated. The FNA technique is the most accurate method for evaluating thyroid nodules. Some molecular markers may be considered to improve diagnostic accuracy. TreatmentAccording to the cytology results the nodules will be considered for surgical excision or for conservative follow-up.