Chronic lamenesses in horses are often managed but not effectively treated. We hypothesize that (1) a causal relationship exists between the forces created by aberrant biomechanical positions and movements, including those caused by the rider, and degenerative joint diseases; and (2) adjusting the aberrant biomechanics will be therapeutic. To test our hypotheses, we constructed a dynamic 3D computer model using equine CT data and human CT data to model full body positions of horses with riders that can then be related to sites of tissue damage in equine lamenesses. The bones of the horse and human were reconstructed from CT data using the 3D visualization and analysis software, Avizo®. The individual bones were then imported into Autodesk® Maya® for re‐positioning into their respective organism, creating a 3D human model and a 3D equine model. A 3D rig was developed for each model separately to allow for accurate positioning and animation for each. The ribbon spine technique was used for the neck and spine on both models for increased accuracy in positioning and movement with the ability to rotate and bend the spines and necks into natural positions. The rigging used for both the horse and human were adopted to be manipulated using controls for quicker and easier positioning. Once the two rigs were completed, they were imported into a single file. The human rig and its matching skeleton were scaled in reference to the equine rig and its matching skeleton; and the human rigged model was positioned atop the rigged equine model to simulate a rider on its horse. The combined model was used to analyze the chronic postural abnormalities of a horse with cervical osteoarthritis using information from photographs of the horse being ridden at the trot. Findings included a markedly asymmetric stride, a dorsiflexed lower limb that indicates overloading of the front legs, and over‐flexion of the neck that correlated with sites of compressive degeneration in the cervical spine. Our long term goal is to expand the models for biomechanical analysis and to further develop the rigging protocol in order to expand its usefulness for both animal and human studies.Support or Funding InformationLouisiana State University School of Veterinary Medicine Charles V. Cusimano Equine Health Studies Program