A clinical approach to the evaluation of sperm-cervical mucus interactions is reviewed. The topics reviewed are 1) sperm passage through the cervix (sperm motility cervical mucus) 2) the cervical passage and infertility (the Sims-Huhner postcoital test the fractional postcoital test and intrauterine lavage in vitro systems the slide test the capillary penetrability test) 3) cervical mucus evaluation 4) sperm evaluation 5) management of cervical factor infertility and 6) prognosis.