Objective. To investigate the stimulated salivary flow (SSF) and unstimulated salivary flow (USF) in adults with acromegaly and to identify possible clinical factors associated with salivary flow. Study design. A case-control study was conducted with a group composed of adults diagnosed with acromegaly (n=29, mean age =50.2 years) and a control group (n=29, mean age =54.3 years). Variables for socio-demographic characterisation, lifestyle habits, and diabetes diagnosis, body mass index (BMI), cervical circumference (CC) and abdominal circumference (AC) were collected. USF and SSF variables were analysed as outcomes. Unpaired t-test, Pearson's correlation, and multivariate regression models were used for statistical analysis. Results. Both groups were 44.8% male and 55.2% female. Diabetes was present in 55.2% of the acromegaly group and in 51.7% of the controls (P = 0.792). The acromegaly group had a higher USF than the control group (0.50 ml/min versus 0.22 ml/min). SSF showed a direct correlation with CC (r = 0.470, P=0.010). Acromegaly was associated with higher USF (standardised coefficient = 0.780, P=0.039), and age was inversely related to USF (standardised coefficient = -0.333, P=0.013). Conclusions. The findings suggest that adults with acromegaly have an increased USF and that being older is associated with a decrease in USF.