Over the past few decades, healthcare has become increasingly more complex, difficult to coordinate among multiple providers, heavily impacted by technology, and subject to situations and conditions that have the potential to diminish quality or breach patient safety. Patients come to hospitals in their most vulnerable state-often in pain, usually fearful, and always feeling a bit out of place. How can this be? Hospitals are supposed to be a safe haven and a place of healing and rest; yet many patients are victims of errors in treatment, procedure, or medication, or they are injured by elements of the hospital environment. A hospital can be a dangerous place for patients because its unfamiliar environment contrasts with home (Tzeng & Yin, 2008a). As designers and healthcare professionals, what can we do to design a healthcare facility that minimizes the potential for risk and enhances patient safety?Although there are many claims that specific design features reduce medication errors, decrease patient falls, lessen cross-contamination, and improve patient safety outcomes, disseminated evidence to support the direct relationship between specific design features and patient outcomes has been sparse. This issue of HERD focuses on patient safety in healthcare design with the intent of adding to a body of knowledge about the relationships between the built environment and patient safety outcomes. I am excited about this issue and fully believe that we will see more research demonstrating the effects of design features on patient safety outcomes that will guide future design decisions. Patient safety should be the number one priority when evaluating the efficacy of design alternatives, and we have unprecedented opportunities to affect quality and patient safety by creating safer work environments for professional staff and safer care environments for patients.A Multidisciplinary ApproachReducing patient risk by means of facility design requires a multidisciplinary approach, because each discipline brings a body of knowledge, viewpoints, preferences, and interpretations to the table to expose hidden assumptions about what could make a difference in ensuring patient safety (Reiling, 2006; Wears, Perry, & Sutcliffe, 2005). We do not often think of safety as a science, yet it is a science with its own body of knowledge, research, and vested academic degrees. According to Wears, When the patient safety movement first began, an important early insight was the realization that a great deal was already known about the problem of safety in complex socio-technical systems based on years of research and practice in a wide variety of (p. 4). Many lessons have been learned from the space program, aviation, the military, and the nuclear power industry that can and have directly influenced assumptions about safety in healthcare design. The same-handed room design concept is one example of borrowing safety knowledge from the aviation field, where all cockpits in certain types of aircraft are designed identically to reduce the potential for pilot confusion and error. Some have accepted this idea as evidence that can be applied to healthcare design (Reiling, 2006).Human factors science applies what is known about human capabilities and limitations to the design of systems, processes, and environments to maximize human potential in the environment and reduce the potential for stress, strains, and errors. Applying human factors science to the healthcare setting, the user (patient) interface with a design would be studied in detail and tested to determine requirements for the built environment that would ensure patient safety (Blanchard & Fabrycky, 1998; Wickens, Lee, Liu, & Gordon Becker, 2004). Some of the research methodologies that could be used as human factors evaluation methods might include: (1) focus groups with patients and providers to identify potential risk areas for patients; (2) ethnography to understand the real-world or lived experience of patients in the healthcare environment; (3) iterative design processes, with each design evaluated in relation to patient safety priorities; and (4) systematic task analysis to evaluate human interaction with the environment under specified conditions (patients with different conditions in specific situations). …