Long‐term heart transplant recipients (HTR) provide a unique opportunity to examine the relationship between the cerebrovascular and cardiovascular systems. We examined the hypothesis that HTR would have cerebral pressure‐flow responses more comparable to control subjects matched to the age of their cerebrovasculature than their donor hearts. Eight male clinically stable HTR (62 ± 8 yrs of age and 9 ± 7 yrs post transplant), 9 male age‐matched controls (AM: 63 ± 8 yrs) and 10 male donor controls (DC: 27 ± 5 yrs), were tested. Each test involved: seated rest (5‐min), and squat‐stand maneuvers at 0.05 and 0.10 Hz. The BRS and pressure‐flow responses were assessed with TFA. BRS TFA revealed that the HTR had reductions in R‐R interval PSD and LF gain (P<0.01) compared to both control groups. There were comparable TFA cerebral pressure‐flow responses for all groups at all frequencies with coherence and phase. The pressure‐flow gain was significantly greater in DC than both AM and HTR at all frequencies (P<0.05). Cerebrovascular resistance (CVR) was negatively correlated with pressure‐flow gain at all frequencies (P<0.05). These results reveal that pressure‐flow coherence and phase are comparable throughout aging, potentially helping HTR compensate for reductions in BRS. Although pressure‐flow gain did decrease in the HTR and AM, it was related to changes in CVR highlighting the need cautiously interpret this metric.Grant Funding Source: Supported by NSERC