Event Abstract Back to Event Reliable soluble markers of neuronal damage after cerebral ischemia Lidija Radenovic1* and V. Lakovic2 1 Faculty of Biology, University of Belgrade, Department of Physiology and Biochemistry, Russia 2 Institute for Medical Research,MMA, Russia The determination of reliable soluble markers of neuronal damages in blood and cerebrospinal fluid (CSF) in early ischemic period would be much easier and more useful for tracking course and prognosis of the disease and for the appropriate therapeutic approach. From the perspective of mitochondrial affection in ischemia, we have investigated dynamics of cytochrome c oxidase (COX) activity in the CSF and plasma of patients with brain infarction (BI), reversible, and transient ischemic attack. We found that COX activity in the CSF and plasma in acute ischemia could be an indicator of brain metabolic dysfunction. Then, we determined neuron-specific enolase (NSE) concentration in CSF, and plasma in BI patients. Significant correlation was found between NSE concentration and infarction volume, the degree ofneurological and functional deficit. The obtained results suggest that an early determination of this marker in CSF and plasma in patients with BI could be a valuable diagnostic factor. Finally, we defined concentration changes of soluble adhesion molecules (sICAM-1, sVCAM-1 and sE-Selectin) in CSF and plasma in BI patients. Again, significant correlation was found between measured parameters and the infarct volume, the degree of neurological and the functional deficit. The results suggest that investigated parameters in CSF and blood represent a dynamic index of inflammatory events as one of the fundamental mechanisms responsible for neuron damage during acute phase of BI. Molecular markers can be useful tools for the management of patients with ischemic stroke, during the acute phase and to predict prognosis and prevent the risk of a new vascular event. Conference: 3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009. Presentation Type: Oral Presentation Citation: Radenovic L and Lakovic V (2009). Reliable soluble markers of neuronal damage after cerebral ischemia. Front. Neurosci. Conference Abstract: 3rd Mediterranean Conference of Neuroscience . doi: 10.3389/conf.neuro.01.2009.16.105 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Nov 2009; Published Online: 23 Nov 2009. * Correspondence: Lidija Radenovic, Faculty of Biology, University of Belgrade, Department of Physiology and Biochemistry, Belgrade, Russia, lidijar@bio.bg.ac.rs Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lidija Radenovic V. Lakovic Google Lidija Radenovic V. Lakovic Google Scholar Lidija Radenovic V. Lakovic PubMed Lidija Radenovic V. Lakovic Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.