Ni-based catalysts show promise as candidates for the dry reforming of methane (DRM), yet the susceptibility to sintering and carbon deposition is a major obstacle to industrialization. This work demonstrates a mesoporous Ni-based catalyst with a thickness-tailorable CeO2 shell for enhanced spatial confinement effect for the DRM. The Ni-MCM-41@xCeO2 catalysts are prepared at various CeO2 shell thickness through a two-step hydrothermal reaction. The kinetic studies have shown that the Ni-MCM-41@2CeO2 catalyst has the lowest activation energy, producing a high conversion of CH4 and CO2 as high as around 80 % at 700 °C. Our characterizations reveal that the Ni core is tightly confined in the mesoporous skeleton of MCM-41 and within a CeO2 shell. The Ni-MCM-41@2CeO2 catalyst is able to sustain high activity for more than 10 h of operation, with a remarkably reduced carbon deposition (0.28 %) as compared with a conventional Ni-Ce/MCM-41 catalyst (8.77 %). Furthermore, the density functional theory (DFT) calculation supports that the CeO2 shell layer significantly reduces dissociation potential barrier for CH4 and CO2, hence enhancing the catalytic activity of the DRM.