This paper presents a computational analysis of a high-speed centrifugal compressor stage where emphasis is focused on both the steady and unsteady flow investigations and on the effect of different number of diffuser vanes on the stage operating range. The simulations were carried out for a centrifugal stage with a backswept impeller and several diffusers with 11, 22 and 33 vanes. For the steady simulations, an averaging approach was used at the interface between the impeller and the diffuser. For the unsteady simulations, geometry scaling was used to deal with the problem of unequal pitch. As the number of diffuser vanes was increased, the pressure recovery coefficient in the semi-vaneless space at surge condition was found to reduce. Also, as the number of diffuser vanes was increased, the flow distortion became more pronounced in the vaneless and semi-vaneless space. It is proposed that this more distorted flow is harmful to the pressure recovery in the semi-vaneless space giving stages with more diffuser vanes narrower flow ranges. It was also found that the diffuser area ratio is not the dominant factor influencing the flow range when the number of diffuser vanes changes.