Natural gas-doped hydrogen transportation has been widely used in industrial engineering. The change of the physical parameters of the conveying medium affects the working performance of the centrifugal compressor. This study aims to explore the aerodynamic performance of centrifugal compressors for hydrogen mixed natural gas, including the effects of hydrogen blending ratio (HBR) and inlet temperature on the pressure ratio and isentropic efficiency of compressors. The numerical simulation method is used and the results are compared with the experimental results to determine the reliability of the numerical simulation method. The results show that the pressure ratio decreases with the increase of HBR where the inlet temperature and rotation speed are constant. The pressure ratio and efficiency of the compressor are the highest when the conveying medium is pure natural gas (HBR = 0). The maximum pressure ratio reduction is 4.8% when the HBR is 5% and the inlet temperature is increased by 20 K. In summary, when the conveying medium of the compressor changes from pure natural gas to hydrogen-mixed natural gas, the working range and efficiency of the compressor will be reduced. Therefore, it is necessary to increase the rotation speed of the compressor or redesign the centrifugal compressor for hydrogen-mixed natural gas in order to achieve a constant flow rate at the outlet of the compressor.