AbstractPurpose: To investigate the relationship between central visual field mean sensitivity (cVFMS) with macular vascularity, ganglion cell layer (GCL) thickness and ganglion cell complex (GCC) thickness in glaucoma patients.Methods: cVFMS was determined by Humphrey Field Analyser Swedish Interactive Thresholding Algorithm (SITA)‐faster 24‐2 and 24‐2C test grids. Foveal avascular zone (FAZ) parameters and macular vessel density (VD) was assessed by optical coherence tomography angiography (OCTA: AngioVue RTVue XR Avanti, Optovue). GCL thickness was measured by Spectralis‐OCT and GCC thickness by Optovue‐OCT. Relationship between vascular parameters, GCL and GCC thickness with cVFMS tested on 24‐2 and 24‐2C grids, was analysed by Pearson correlation coefficient. The comparison between correlation coefficients was performed by Steiger test.Results: Transversal study involving 50 eyes from 43 glaucoma patients. No significant correlation was found between FAZ area or perimetry and cVFMS. Instead, lower foveal vessel density (FD300) was associated with worse cVFMS in 24‐2 and 24‐2C grids (0.437, p = 0.006 and 0.438, p = 0.006, respectively). Significant correlations between macular VD and cVFMS were found both with 24‐2 and 24‐2C test grids: cVFMS24 versus whole VD (0.529, p = 0.001) and cVFMS24‐2C vs whole VD (0.553, p < 0.001), cVFMS24 vs parafoveal VD (0.565, p < 0.001) and cVFMS24‐2C vs parafoveal VD (0.602, p < 0.001), cVFMS24 vs perifoveal VD (0.514, p = 0.001) and cVFMS24‐2C vs perifoveal VD (0.539, p < 0.001). GCL and GCC thickness were also associated with cVFMS24 (0.566, p < 0.001 and 0.568, p < 0.001, respectively) and with cVFMS24‐2C (0.542, p < 0.001 and 0.544, p < 0.001, respectively). Worse superior hemi‐cVFMS 24‐2 and 24‐2C was significantly correlated with lower inferior hemimacular VD, GCL and GCC thickness. Similar results were obtained when comparing inferior hemi‐cVFMS with superior hemimacular parameters. No significant differences were detected between correlations with 24‐2 and 24‐2C grids.Conclusions: The FD300, but not FAZ area or perimetry, was correlated with cVFMS. Worse cVFMS was correlated with lower macular VD and lower GCL and GCC thickness both with 24‐2 and 24‐2C test grids.