The National Institutes for Quantum and Radiological Science and Technology has the responsibility to develop a cable-in-conduit conductor (CICC) for the ITER central solenoid (CS). Qualification tests of CICCs fabricated in the initial development stage were carried out at the SULTAN test facility; the superconducting performance (Tcs = current-sharing temperature) was found to be degraded by the repeated cyclic loading that simulates realistic ITER operating conditions. From destructive examination and neutron diffraction tests, this degradation appears to result from bending strain on the strands generated by electromagnetic forces. In response, the cabling of the CICC was optimized by shortening the twist pitch to make it stiffer against electromagnetic forces. No Tcs degradation of the optimized CICC was seen in the subsequent SULTAN test; further, a CS insert (CSI) test was performed at the CS model coil test facility, which included hoop strain for a more realistic simulation of ITER conditions. Good performance was also achieved in the CSI test.