In order to investigate the climate effects of dusts, a regional climate model (RegCM 4.6) with the dust scheme was used to simulate the direct radiative forcing and air temperature response at 2 m near surface of dusts over the eastern Asia. Two sets of experiments were conducted, one with and one without dust aerosols. The experiment covered the main dust occurrence months from March to May for 8 years (2011−2018), and the simulation results were evaluated against ground station, reanalysis and satellite data. The model captured the spatiotemporal distribution of dust AOD and mass loading over the eastern Asia. However, it tended to underestimate the dust AOD and mass loading over the downwind of the dust source region and the Taklimakan Desert, and overestimate them over the north Xinjiang. The direct net radiative forcing including shortwave and longwave was up to −20 W·m−2 at the surface and −10 W·m−2 at the TOA over the dust source region due to the dominant negative shortwave forcing. The only exception of positive forcing at the TOA was observed along the western boundaries of the Tibetan Plateau due to the semi-persistent ice and snow cover. The dusts tended to warm the atmosphere more than 18 W·m−2 and cool the surface locally up to −0.7 °C. Among the 5 sub-areas, the largest averaged regional direct radiative forcing induced by dusts appeared over the central Inner Mongolia in May with the value of −3.0 ± 2.1, −12.2 ± 4.1 and 9.2 ± 4.4 W·m−2 at the TOA, surface and in the atmosphere, respectively. The results indicated that the model simulation for dusts should be further improved and the dust effects should be included in the estimates of climate change over the eastern Asia.