Airborne gamma-spectrometry and subsequent radiometric field investigations in central East Greenland have revealed a number of areas of above average radioactivity and a number of radioactive anomalies within these areas. These areas can be divided geologicaIly into: pre-Caledonian crystalline basement, late and post-Caledonian plutonic rocks, Tertiary plutons and areas of intensive faulting and shearing. Areas bordering continental sedimentary formations are envisaged as potential host rocks for epigenetic uranium mineralization. The spectrometer system applied, with a detector volume of 3.7 litres, does not completely satisfy a quantitative evaluation of the spectrometric data recorded and a distinction between major rock units is only possibie from the gross channel count rates.