Central Auditory Processing Research Articles

Sensory profile of children with Central Auditory Processing Disorder (CAPD).

To analyze the sensory profile of children with auditory sensory processing disorder according to the Child Sensory Profile 2 and to verify potential associations between central auditory processing and sensory processing. Sixty children from two public schools in the city of João Pessoa, state of Paraíba, were evaluated. All children had their cognitive skills tested and their socioeconomic and demographic information collected. The children's hearing, central auditory processing, and sensory processing were evaluated. SPSS Statistics version 25.0 was used for data analysis and the significant value adopted was 0.05. Descriptive analysis was performed using the central tendency method. The similarities among the test variables were measured by Student's t-test and Mann-Whitney U test. The effect size (ES) between the groups was measured by Cohen's d or Rosenthal's r coefficient. The average age of children with CAPD was 8.4 years, and their families had lower levels of income and education when compared to those without the disorder. Children with CAPD present more sensory differences than their peers with normative CAP. The Child Sensory Processing 2 results didn't show any statistic associations with central auditory processing, and the effect size was of moderate magnitude for the visual system. Children with CAPD have more sensory differences than their peers according to the normative results of the Child Sensory Profile 2. An association between sensory and central auditory processing was not observed, except for the visual system.

Central auditory processing in children after traumatic brain injury

IntroductionTraumatic brain injury can impair the central auditory pathways and auditory cortex. Hence, individuals who suffered a traumatic brain injury may be at risk of central auditory processing disorders, which can be identified with behavioral tests that assess central auditory function. ObjectiveTo characterize and compare the performance of children and adolescents with and without a history of traumatic brain injury in behavioral tests that assess central auditory processing. MethodThe sample comprised 8- to 18-year-old individuals of both sexes who suffered moderate or severe closed traumatic brain injury 3 to 24 months before their participation in the study and whose hearing thresholds were normal. These individuals were matched for sex and age with other subjects without a history of traumatic brain injury and submitted to behavioral assessment of the central auditory processing with special tests to assess hearing skills (namely, auditory closure, figure-ground, and temporal processing), selected according to their chronological age and response-ability. ResultsThe study group performed statistically worse than the comparison group in auditory closure, figure-ground in verbal dichotic listening, and temporal ordering. The central auditory processing tests with abnormal results in the comparison group were different from those in the study group. ConclusionCentral auditory processing disorders were identified in all subjects of the study group, especially involving auditory closure and temporal processing skills, in comparison with subjects without a history of traumatic brain injury.

Testes para a avaliação comportamental das habilidades auditivas centrais em indivíduos com perdas auditivas neurossensorial: uma revisão integrativa

ABSTRACT Purpose: to identify the most used tests and the changed hearing skills in the central auditory processing of individuals with sensorineural hearing loss. Methods: an integrative literature review conducted between March and August 2021 in PubMed/MEDLINE, LILACS, SciELO, IBECS, and Index Psi Scientific Journals. The review included studies addressing central hearing skills with central auditory processing behavioral tests in subjects with mild to moderate sensorineural hearing loss. Two independent reviewers made the study selection, data extraction, and qualitative synthesis. The selection aimed at verifying whether the studies answered the research question. Literature Review: 39 studies were found for full-text reading; after applying the eligibility criteria, 13 studies were included in the review. Participants diagnosed with sensorineural hearing loss predominantly had hearing changes in verbal tests, in comparison with normal standards for individuals without hearing loss. Thus, the most changed skills are the ones that depend on speech sound discrimination. Conclusion: the Staggered Spondaic Word Test predominated among the most used behavioral tests, while the most researched central auditory skills were binaural integration and binaural separation.

Effect of Postnatal Thiamine Deficiency on Central Auditory Processing During Adulthood

Effect of Postnatal Thiamine Deficiency on Central Auditory Processing During Adulthood

Frequency-Following Response e Potencial Evocado Auditivo de Média Latência: uma análise frente ao processamento auditivo central de jovens adultos

ABSTRACT Purpose: to compare the latency and amplitude of the Frequency-Following Response and the Auditory Middle Latency Response in typical individuals and those with altered auditory abilities, as well as to investigate the sensitivity and specificity of both assessments in relation to central auditory processing. Methods: 32 individuals of both sexes were distributed into Group 1 (without altered auditory abilities) and Group 2 (with altered auditory abilities). The groups were divided according to behavioral tests of central auditory processing. Individuals in both groups underwent auditory evoked potentials. Student’s t-test was used for analysis, considering a 5% significance. Results: in Group 2, V and A had higher latency and lower amplitude and slope. Group 2 also had lower Na and Pa amplitudes in waves A1C3 and A2C3. The Frequency-Following Response showed 93% sensitivity and specificity, while the Auditory Middle Latency Response showed 87% sensitivity and 93% specificity. Conclusion: the individuals presented with altered hearing abilities showed higher latency and lower response amplitude in the Frequency Following Response and Auditory Middle Latency Response compared to typical individuals. The Frequency- Following Response showed a better balance of sensitivity and specificity.

Evaluation of Medial Olivocochlear Neural Efferent Pathway in Tinnitus Perception in Normal-hearing Individuals.

The objective of this study is to investigate a possible role of the Medial Olivocochlear (MOC) efferent neural pathway and neural connections responsible for tinnitus generation in silence/sensory deprivation. By placing normal hearing participants in a sound booth for 10 minutes, silence/sensory deprivation was created. This offered assessment of MOC neural pathway in normal hearing participants in silence. Hyperactivity of MOC neural pathway was assessed by its more suppressive effect on Transient Otoacoustic Emissions (TEOAEs) in silence. The required auditory measurements were recorded in the sound booth using recommended diagnostic protocols to ensure the effect of 'only silence' on auditory structures. TEOAE were recorded from the right ear and suppression was measured by placing noise in the left ear. Fifty-eight normal hearing male individuals between age 18-35 years were recruited as participants in this study. Approximately, forty-one percent of the participants perceived some type of tinnitus during/after 10 minutes of silence. No statistically significant difference was found in the total TEOAE amplitude and TEOAE suppression amplitude before and after ten minutes of silence. Post silence total TEOAE suppression between tinnitus perceiving and non-perceiving tinnitus participants were not statistically significantly different. These results suggest that the medial olivocochlear efferent pathway or lower brain stem area does not appear to play a role in the emergence of temporary tinnitus in silence however indicate the involvement of higher central auditory nervous system structures in perception of the tinnitus which support the well-accepted notion that tinnitus is the central auditory processing phenomenon.

Влияние контралатеральной помехи на разборчивость речи при слухопротезировании

The actual problem of audiology is to find out the causes of poor results of hearing aid, to forecast and develop ways to improve their effectiveness. Objective. To evaluate the noise immunity of the auditory system in persons with normal hearing and in patients with chronic sensorineural hearing loss (SNHL) with contralateral presentation of interference and the degree of influence of contralateral interference on speech intelligibility during the use of hearing aid. Patients and methods. 24 patients with bilateral symmetrical chronic moderate/moderately severe sensorineural hearing loss aged 38 to 83 years, fitted with modern digital hearing aids, and 10 persons with normal hearing were examined. According to the results of a comprehensive assessment of the central departments of the auditory system, two groups of patients with hearing loss were formed: without signs and with signs of central auditory processing disorder (CAPD). The noise immunity of the auditory system with contralateral presentation of tonal interference and the degree of its influence on speech intelligibility were investigated. Speech intelligibility was assessed by means of the Russian matrix sentence test (RuMatrix) in a free sound field. Results. In patients with CAPD, there was a significant decrease in the noise immunity of the auditory system, which worsened speech intelligibility and led to a decrease in the effectiveness of binaural prosthetics in speech perception in noise; an interhemispheric asymmetry of the effect of contralateral interference on speech intelligibility was noted.

Frequency-Following Response and Auditory Middle Latency Response: an analysis of central auditory processing in young adults

RESUMO Objetivo: comparar a latência e a amplitude do Frequency-Following Response e do Potencial Evocado Auditivo de Média Latência em indivíduos típicos e com alterações das habilidades auditivas, assim como investigar a sensibilidade e especificidade de ambas as avaliações frente ao processamento auditivo central. Métodos: 32 indivíduos de ambos os sexos foram distribuídos em Grupo 1 (sem alterações de habilidades auditivas) e Grupo 2 (com alteração em habilidades auditivas). Os grupos foram divididos de acordo com testes comportamentais do processamento auditivo central. Os indivíduos de ambos os grupos foram submetidos aos potenciais evocados auditivos. O teste T de Student foi utilizado para a análise, considerando 5% de significância. Resultados: no Grupo 2, V e A apresentaram maior latência e menor amplitude e slope. O Grupo 2 também apresentou menores amplitudes de Na e Pa nas ondas A1C3 e A2C3. O Frequency-Following Response apresentou 93% de sensibilidade e especificidade, enquanto o Potencial Evocado Auditivo de Média Latência apresentou 87% de sensibilidade e 93% de especificidade. Conclusão: os indivíduos com alteração das habilidades auditivas apresentaram maior latência e menor amplitude de resposta no Frequency Following Response e Potencial Evocado Auditivo de Média Latência em relação aos indivíduos típicos. O Frequency-Following Response apresentou melhor equilíbrio de sensibilidade e especificidade.

Neural mechanism, prognosis, and rehabilitation of central auditory processing disorder: a review

Neural mechanism, prognosis, and rehabilitation of central auditory processing disorder: a review

Mild Traumatic Brain Injury: Long-Term Follow-Up of Central Auditory Processing After Auditory Training.

Background and ObjectivesEven a mild traumatic brain injury can impair the peripheral and central parts of the auditory system. The objective was to compare the performance of individuals with mild traumatic brain injury in behavioral and electrophysiological central auditory tests before and after formal auditory training, and to verify the stability of these measures over time. Subjects and MethodsTen 16- to 64-year-old individuals diagnosed with mild traumatic brain injury underwent behavioral and electrophysiological assessment of the central auditory processing in three stages: before, right after, and six months after formal auditory training. ResultsStatistically significant differences were observed for speech by white noise, synthetic sentence identification, sound localization, verbal sequential memory, and duration pattern tests in the assessment six months after formal auditory training. No statistically significant differences were observed between the P300 assessments, either with tone-burst or speech stimulus, in N2 and P3 latencies, and P3 amplitude. ConclusionsThe results of the behavioral assessment of the central auditory processing improved, while the P300 remained stable with both stimuli, six months after completing formal auditory training. This demonstrates that auditory training has long-term benefits for people with mild traumatic brain injury.

Associations of Central Auditory Processing With Brain Volumes

We investigated the cross-sectional associations of speech-in-noise performance with magnetic resonance imaging brain volumes among 588 cognitively normal participants (77±4 years, 56% female) from the Aging and Cognitive Health Evaluation in Elders Study (randomized trial embedded in the Atherosclerosis Risk in Communities (ARIC) Study) baseline in 2018-19 (N=427, with hearing loss) and ARIC (N=161, normal hearing) Visit 6/7 in 2016-17/2018-19. Central auditory processing was measured by Quick Speech-in-Noise (QuickSIN) test; range: 0 to 30, lower scores=worse performance. In models adjusted for demographic and disease covariates, every 5-point decrease in QuickSIN score was associated with smaller volumes of the temporal lobe overall (-0.07SD, 95% CI:-0.13,-0.01) as well as subregions including but not limited to those important for auditory processing (amygdala:-0.13SD, 95% CI:-0.21,-0.04; middle temporal gyrus:-0.08SD, 95% CI:-0.15,-0.00; superior temporal gyrus:-0.08SD, 95% CI:-0.15,-0.01). Further research is needed to understand the mechanisms underlying these observed associations.

Hearing and Vision Impairment in Older Adults: Implications for Cognitive, Mental, and Brain Health

Sensory impairment impacts over 55% of Americans aged 60 years or older and may have important downstream consequences for the cognitive health of older adults. This session will present evidence for a relationship between sensory impairment and accelerated cognitive decline, increased risk of incident dementia, and increased mental and physical fatigability from two observational cohort studies. Additionally, this session will investigate the possible nature of these relationships. It may be that sensory impairment is a marker of dementia-related pathological changes in the brain, with potential ramifications for risk prediction and stratification. Alternatively, sensory impairment may have a direct impact on the aging brain, a potential causal mechanism liking sensory impairment and brain health, with implications for disease prevention. As part of this session, we will present evidence for associations between central auditory processing, a potential risk marker, and brain volumes measured with structural magnetic resonance imaging (MRI), and retinal vasculature density, as measured with optical coherence tomography. We will conclude by describing associations between age-related macular degeneration, a leading cause of blindness, and neurocognitive test performance and regional changes in brain atrophy and connectivity.

Associations of Habitual Sleep Duration and Sleep Stages With Speech-in-Noise Performance

Speech-in-noise performance involves central auditory and cortical processing and is fundamental to communication. We investigated cross-temporal associations of habitual sleep duration and stages (1996-1998) with speech-in-noise performance (2016-2017) in a subset of the Atherosclerosis Risk in Communities Study participated in the Sleep Heart Health Study(N=755, 61±5 years, 53% female). Speech-in-noise performance was measured by Quick Speech-in-Noise Test; range:0-30; lower scores=worse performance. Time spent in each stage (stage 1;2;3/4;rapid eye movement (REM)) was measured by polysomnography. Habitual sleep duration was calculated by self-reported duration on weekdays and weekends. In models adjusting for demographic and disease covariates, every 10-minute increase in REM sleep was associated with better speech-in-noise performance (0.10 points,95% CI:0.00,0.21); every 1-hour increase in habitual sleep duration was associated with worse speech-in-noise performance (-1.28 points,95% CI:-2.49,-0.08) among participants sleep >8 hours. Long sleep duration might be a risk marker of speech-in-noise performance, but REM sleep might be a protective factor.

Auditory Dysfunction Among Individuals With Neurofibromatosis Type 1

Neurofibromatosis type 1 (NF1) affects hearing through disruption of central auditory processing. The mechanisms, functional severity, and management implications are unclear. To investigate auditory neural dysfunction and its perceptual consequences in individuals with NF1. This case-control study included children and adults with NF1 and control participants matched on age, sex, and hearing level. Patients were recruited through specialist neurofibromatosis and neurogenetic outpatient clinics between April and September 2019. An evaluation of auditory neural activity, monaural/binaural processing, and functional hearing was conducted. Diffusion-weighted magnetic resonance imaging (MRI) data were collected from a subset of participants (10 children with NF1 and 10 matched control participants) and evaluated using a fixel-based analysis of apparent fiber density. Type and severity of auditory dysfunction evaluated via laboratory testing and questionnaire data. A total of 44 participants (18 [41%] female individuals) with NF1 with a mean (SD) age of 16.9 (10.7) years and 44 control participants (18 [41%] female individuals) with a mean (SD) age of 17.2 (10.2) years were included in the study. Overall, 11 participants (25%) with NF1 presented with evidence of auditory neural dysfunction, including absent, delayed, or low amplitude electrophysiological responses from the auditory nerve and/or brainstem, compared with 1 participant (2%) in the control group (odds ratio [OR], 13.03; 95% CI, 1.59-106.95). Furthermore, 14 participants (32%) with NF1 showed clinically abnormal speech perception in background noise compared with 1 participant (2%) in the control group (OR, 20.07; 95% CI, 2.50-160.89). Analysis of diffusion-weighted MRI data of participants with NF1 showed significantly lower apparent fiber density within the ascending auditory brainstem pathways. The regions identified corresponded to the neural dysfunction measured using electrophysiological assessment. The findings of this case-control study could represent new neurobiological and clinical features of NF1. Auditory dysfunction severe enough to impede developmental progress in children and restrict communication in older participants is a common neurobiological feature of the disorder.

Evaluation of temporal processing skills in individuals with normal hearing

Objective: In a cumulative perspective, the aim of this study is to perform Frequency Pattern Test (FPT), Duration Pattern Test (DPT) and Gap In Noise (GIN) Test in order to determine descriptive values of these tests to evaluate central auditory processing on the individuals’ with normal hearing. Material and Methods: A total of 52 participants, as of 28 women and 24 men, with normal hearing, within the age range of 20 to 55 were included in the study. Otoscopic examination, pure tone audiometry and FPT, DPT GIN Test which are central auditory processing tests, were performed on the participants who meet the criteria of the study and voluntarily agreed to participate in the study. Results: Descriptive values were obtained as an average of 78% in FPT, 92.11% in DPT, an average of 61.22% in GIN Test and an average of 6.34 ms in Gap Detection Threshold Conclusions: It is thought that the obtained descriptive values will contribute to the clinics and the literature. Keywords: Auditory temporal tests, central auditory processing, duration pattern test, frequency pattern test, gap in noise test

Associations of central auditory processing with brain volumes in the aging and cognitive health evaluation in elders and the atherosclerosis risk in communities neurocognitive study

AbstractBackgroundPrior evidence has suggested associations between hearing loss and smaller brain volumes particularly in the temporal lobe where the primary auditory cortex is located, probably due to changes in cortical organization associated with reduced auditory stimulation. Evidence regarding associations of central auditory processing with brain volumes is relatively limited. The study aims to investigate cross‐sectional associations of central auditory processing with brain volumes in older adults.MethodWe studied 587 cognitively normal (Mini‐Mental State Exam ≥23 if high school degree or less and ≥25 if above high school degree) older adults (mean age: 77±4 years, 56% female, 17% black), including 426 with hearing loss from the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) baseline (2018‐19), which is an ancillary randomized controlled trial of the Atherosclerosis Risk in Communities (ARIC) Study and 161 with normal hearing, comparable age and cognitive status from the ARIC Visit 6/7 (2016‐17/2018‐19). Brain volumes were measured by magnetic resonance imaging (MRI) scans and were transformed to z‐scores. Central auditory processing was measured by the Quick Speech‐in‐Noise (QuickSIN) test. Total scores range from 0 to 30 with lower scores indicating worse speech‐in‐noise performance. Multivariable‐adjusted linear regression was used to estimate cross‐sectional differences in standardized brain volumes associated with differences in QuickSIN score. Models adjusted for age, sex, race, education, cohort, body mass index, smoking, hypertension, diabetes, stroke, intracranial volume, and pure‐tone average.ResultEvery 5‐point decrease in QuickSIN score (worse performance) was associated with smaller volumes of the temporal lobe (‐0.07SD, 95% CI: ‐0.13, ‐0.01). QuickSIN score was also associated with subregions of the temporal lobe related to auditory processing, memory and emotion, including amygdala (‐0.13SD, 95% CI: ‐0.21, ‐0.04), middle (‐0.08SD, 95% CI: ‐0.15, ‐0.00) and superior temporal gyri (‐0.08SD, 95% CI: ‐0.15, ‐0.01).ConclusionPoorer central auditory processing was associated with smaller temporal lobe volumes, including but not limited to subregions important for auditory processing. The ongoing collection of ACHIEVE data with longitudinal MRI data will facilitate understanding of association between hearing loss and brain atrophy as well as the potential promising effects of hearing treatment in mitigating brain aging.

Impairment of auditory integration in subjective cognitive decline, amnestic mild cognitive impairment, and Alzheimer’s disease

AbstractBackgroundLocalization of sound sources in a noisy environment or ‘auditory scene analysis’ depends on central auditory processing (CAP) that is vulnerable in cognitive impairment. Here, we investigated the behavioral and electrophysiological characteristics of auditory integration, as a particular function in CAP, in relation to neuropsychological functions in SCD, aMCI, and AD.MethodWe introduced a binaural integration paradigm to measure sound‐localization‐related features (identification and retention of acoustic signals) by detecting break in interaural correlation (BIC) and primitive auditory memory (PAM) in wideband noises. We used a 128‐channel EEG to record the event‐related‐potential (peak amplitude, peak latency, and inter‐trial phase coherence [ITPC]) for the paradigm.ResultA total of 121 participants (mean age 65.9 years) were included. Significant differences in BIC detection and PAM were revealed between groups adjusting for age and gender (BIC: F = 20.2, P < 0.001; PAM: F = 24.6, P < 0.001). Post‐hoc analysis showed that BIC detection and PAM were significantly higher in NC or SCD groups compared with aMCI or AD groups. Further adjusting for neuropsychological scores, the significances were not changed, suggesting that auditory integration impairment was partially independent from top‐down cognitive functions. In EEG experiment, the most prominent differences in EEG metrics among the four groups included the ITPC of N1 at left parietooccipital region (F = 3.85, P = 0.012) and of P2 at left parietooccipital (F = 3.89, P = 0.011) and frontocentral regions (F = 8.09, P < 0.001). Notably, there was a linear decrease for the ITPC of N1 and a U‐shape‐curve change for the ITPC of P2 among the four groups, indicating that EEG patterns are differentially modulated depending on disease severity. For the discrimination of AD vs NC and MCI vs NC, the AUC was 0.92 and 0.85 for BIC detection; 0.94 and 0.90 for PAM, respectively.ConclusionAuditory integration, as a partially independent phenotype, is impaired in aMCI and AD populations. A U‐shape‐curve change of P2 with the increasing disease severity was found, indicating a compensation on auditory scene analysis. Results support binaural integration paradigm as a biomarker for screening cognitive decline and identifying auditory integration deficit.

Invoking the influence of emotion in central auditory processing to improve the treatment of speech impairments.

Objectives:To explore the benefits of invoking unconscious sentiment to improve the treatment of stuttering and misarticulation.Methods:This cross-sectional study of 80 participants with speech issues (44 patients with misarticulation and 36 with stuttering) who underwent comprehensive speech and hearing evaluations to confirm and diagnose speech difficulties. Speech and language pathologists then calculated either the percentage of correctly pronounce sounds in misarticulation cases or stuttering severity index-4 scores in cases of stuttering following the use of therapeutic stimuli recorded with familiar and non-familiar voices of similar linguistic and phonetic complexity. Descriptive and inferential statistics were used to compare the data collected following the use of familiar and unfamiliar stimuli.Results:The analysis showed that the number of dysfluencies in cases of stuttering were significantly fewer when employing familiar voices than unfamiliar voices (3% errors vs 12% errors; Z= -5.16 p<0.001). Additionally, the percentages of correct pronouncing of target sounds in cases of articulation disorders were prominently higher when using familiar voices compared with unfamiliar voices (88% PCC vs 66% PCC; Z= -5.65, p<0.001)Conclusion:This study confirms the utility of invoking emotion in improving speech therapy and maximizing therapeutic outcomes. This study also recommends engaging families and friends in providing speech services to the speech-impaired population to improve patient progress.

An auditory-visual tradeoff in susceptibility to clutter

Sensory cortical mechanisms combine auditory or visual features into perceived objects. This is difficult in noisy or cluttered environments. Knowing that individuals vary greatly in their susceptibility to clutter, we wondered whether there might be a relation between an individual’s auditory and visual susceptibilities to clutter. In auditory masking, background sound makes spoken words unrecognizable. When masking arises due to interference at central auditory processing stages, beyond the cochlea, it is called informational masking. A strikingly similar phenomenon in vision, called visual crowding, occurs when nearby clutter makes a target object unrecognizable, despite being resolved at the retina. We here compare susceptibilities to auditory informational masking and visual crowding in the same participants. Surprisingly, across participants, we find a negative correlation (R = –0.7) between susceptibility to informational masking and crowding: Participants who have low susceptibility to auditory clutter tend to have high susceptibility to visual clutter, and vice versa. This reveals a tradeoff in the brain between auditory and visual processing.

Deficits in central auditory processing among migraine patients

BackgroundMigraine is a neurological disease associated with abnormal excitability in visual, somatosensory, and motor cortex. This study aimed to verify and compare auditory processing performance in migraine patients with and without dizziness and healthy controls.ResultsSixty subjects were divided into 3 groups: control group, twenty normal healthy subjects, and study group I (twenty subjects diagnosed with migraine) and study group II (twenty subjects diagnosed with vestibular migraine). They were evaluated using the Central Auditory Processing Questionnaire for adults, tympanometry, pure tone audiometry, Psychophysical Central Auditory Tests, including Arabic Speech Intelligibility in Noise Test for adults, Arabic Dichotic Digit Test [version II], Gap in Noise Test, Duration Pattern Test, and Arabic Memory Tests. No significant difference was found between the two study groups I and II, but the significant difference was found between the study groups and the control group in all central auditory test results. Statistically significant difference was found between the control group and study groups I and II regarding all memory tests. The highest percentage of abnormality was present in temporal resolution and selective auditory attention in both study groups. There was no significant statistical correlation between the number of attacks/month and central auditory test results. There was no significant statistical correlation between the frequency of attacks in VM patients and central auditory test results.ConclusionsPatients with migraine and vestibular migraine had an inferior performance in all psychophysical central auditory tests when compared with control. Also, there was no significant difference between the 2 study groups regarding central auditory test results which may support that both migraine with and without dizziness have the same pathophysiology.