Central Administration Research Articles

Balancing Act: A Comparative Study of Routing Protocol Trade-Offs in MANETs

Mobile ad hoc networks (MANETs) are decentralized networks of mobile devices connected by wireless links, enabling various applications across domains. Research on MANETs often relies on simulations for efficient and replicable evaluations due to the absence of central administration and complex real-world scenarios. Effective simulation necessitates the integration of mobility models to orchestrate node movement. In this study, we explore existing mobility models, propose evaluation metrics, and conduct simulations to characterize, compare, and rank these models. Additionally, we analyze ad hoc routing protocols, focusing on packet delivery ratio, average packet arrival time, and total control packets. Notable protocols such as AODV, DSR, DSDV, and TORA are scrutinized, considering factors like node count and mobility, to provide comprehensive insights into their performance and efficacy.

The role of pallidal substance P and neurokinin receptors in the consolidation of spatial memory of rats.

The tachykinin substance P (SP) facilitates learning and memory processes after its central administration. Activation of its different receptive sites, neurokinin-1 receptors (NK1Rs), as well as NK2Rs and NK3Rs was shown to influence learning and memory. The basal ganglia have been confirmed to play an important role in the control of memory processes and spatial learning mechanisms, and as part of the basal ganglia, the globus pallidus (GP) may also be involved in this regulation. SP-immunoreactive fibers and terminals, as well as NK1Rs and NK3Rs, were shown to be present in the GP. The present study aimed to examine whether the SP administered into the GP can influence spatial memory consolidation in the Morris water maze (MWM). Therefore, male Wistar rats received a post-trial microinjection of 0.4 microliters of 10ng SP, 100ng SP, or vehicle solution. The possible involvement of pallidal NK1Rs and NK3Rs in the SP effects was also studied by applying WIN51708 for NK1R antagonism and SR142801 as a selective NK3R antagonist. Our results showed that the lower dose of SP significantly decreased escape latency on the second day compared to control animals, while the higher dose was ineffective. Prior treatment with the NK1R antagonist WIN51708 could not block, while the NK3R antagonist SR142801 inhibited the effects of SP on memory consolidation in the MWM. Our results are the first to demonstrate that SP improves consolidation of spatial memory in the GP, and this effect is mediated through NK3Rs but not NK1Rs.

Evaluating the impact of COVID-19 protection measures and staff absence on radiotherapy practice: A simulation study.

Radiotherapy practice for cancer treatment is resource-intensive and demands optimised processes for patient throughput while guaranteeing the quality and safety of the therapy. With the COVID-19 pandemic, ad-hoc changes in the operation of radiotherapy centres became necessary to protect patients and staff. This simulation study aimed to quantify the impact of designated COVID-19 protection measures and pandemic-related staff absence on patient waiting times and throughput. The approach also enables analysis of protective measures and process adjustments for future business disruptions. A discrete event simulation model of a stand-alone radiotherapy centre was developed and used to analyse changes in patient flow when implementing COVID-19 protection measures and experiencing staff absence. The simulation results support business continuity planning and decision-making in radiotherapy. In total, twenty-one scenarios in three categories were analysed. Category 1 scenarios investigated the effect of healthcare staff and equipment shortfalls. Category 2 scenarios simulated the impact of additional COVID-19 protection measures at low COVID-19 incidence rates, while category 3 scenarios evaluated the changes at high incidence rates. The simulation results suggested increased patient waiting times when staff is absent. Most scenarios of the three categories behave similarly despite increased patient waiting times due to COVID-19 protection measures in categories 2 and 3. The most significant increase in patient waiting times occurs when only two radiation therapists are available. The absence of a linear accelerator for cancer treatment also leads to increased waiting times. Scenarios where one administrator is absent show the longest average and maximum waiting times for low COVID-19 incidence rates. COVID-19 protection measures reduce patient throughput. In all scenarios, with reduced patient throughput, follow-up radiation appointments were affected. The simulated scenario results suggest that appropriate staffing of the radiotherapy centre during a pandemic crisis is essential and that staff absence can lead to prolonged patient waiting times and reduced throughput with severe continuity of care consequences. The simulation model demonstrated that centre administrators are a bottleneck if they must perform COVID-19 protection measures in addition to their administrative duties. The effect could be mitigated by outsourcing COVID-19 protection tasks to external service providers or other centre staff.

CSR practices in human capital management in local government administration on the example of Staszów county in Świętokrzyskie voivodeship

ObjectivesIn recent years, there have been a number of initiatives to promote the social responsibility of public administration. The concept has largely become recognized in the central administration, but it is different at the regional or local administration level. Thus, the purpose of the study is to identify, review CSR activities and assess the extent of their application in the area of human resources management in local government units, i.e. at the local level. An indirect goal of the study is also to promote the idea of social responsibility among representatives of regional and local administrations.Material and methodsThe purpose of the research was to identify and review CSR activities and assess the extent of their application in the area of human capital management in local government units at the local level. The research was conducted using a structured interview with municipal managers (mayors, secretaries of municipalities) according to a prepared interview questionnaire.ResultsThe research identified CSR practices used by municipalities in the area of human capital management. These were mainly related to organizing working time, integrating employees, building ethical standards, and spreading preventive health and healthy lifestyles.ConclusionsIn the surveyed municipal offices, practices were identified that can be categorized as activities within the framework of social responsibility of administration, mainly in such areas as work organization, integration of employees, building ethical standards or spreading preventive health and healthy lifestyles. 5. CSR activities undertaken in offices also testify to the growing awareness of local government management of the importance of the human factor for the efficiency of the entity, as well as the influence of employees on its performance.

Jean Barré de Saint-Venant et la colonisation nouvelle

The aim of this article is to explore the intellectual and political trajectory of the Dominguan planter, scientist, and agronomist Jean Barré de Saint-Venant (1737-1810). As a member of the Circle of the Philadelphes and of the Chamber of Agriculture of Le Cap Français, between the end of the Old Regime and the Napoleonic period, Barré de Saint-Venant outlined through his memoires and printed works a creole path to agricultural, economic, and institutional progress in the plantation society of Saint-Domingue. By blending philosophy, racial theory, colonial history, scientific experiments, and empirical knowledge, his reflection and action within the central and peripheral imperial administration demonstrate the active participation of Barré de Saint-Venant and other Dominguan colonists in the pursuit of a so-called «colonisation nouvelle», based on expertise in the service of the legislator, on technological and governmental modernisation, on the promotion of an enlightened public sphere, and on the exploitation of the enslaved African. On the other hand, Barré de Saint-Venant’s ideas and reform projects invite us to reflect further on the notion of «Caribbean Enlightenment».

The Effect of Music on the Happiness of Turkmen Elderly Turkman in Day Care Centers

Introduction: Happiness is essential for all age groups, particularly the elderly. This study aimed to investigate the impact of music on the happiness levels of elderly Turkman individuals residing in Day Care Centers in Bandar Turkman and Gomishan cities, Golestan province, Iran, in 2023. Methods: A quasi-experimental, before-and-after design was employed, involving 74 elderly participants from two day care centers in Golestan province. Of the total elderly population in day care centers in Bandar Turkman and Gomishan cities (95 people), 37 people from Bandar Turkman (intervention group) and 37 people from Gomishan (control group) were selected and entered into the study based on the inclusion criteria using convenience sampling. Group matching was conducted based on gender. Happiness was assessed using the Oxford Happiness Inventory at the beginning and end of the intervention for both groups. The intervention consisted of 12 group music therapy sessions, each lasting 45-50 minutes, three times a week, involving the playing of happy Turkman music. Data analysis were performed using SPSS version 26, including Chi-square, Pearson correlation, and independent t-tests. Results: The mean happiness score post-intervention was significantly higher in the intervention group (70.51 ± 8.17) compared to the control group (28.43 ± 6.93) (p < 0.05). Additionally, a significant increase in mean happiness scores was observed within the intervention group before and after the intervention (p < 0.05). The impact of music intervention on happiness varied based on factors such as marital status (p < 0.05), employment status (p < 0.05), education level (p < 0.05), and gender (p < 0.05). Conclusion: Given the positive influence of music on the happiness of elderly individuals, music therapy can be a valuable tool to enhance their mental health. To promote active and joyful aging, it is recommended that elderly care center administrators incorporate authorized and local music into their programs.

Occupational therapy embedded in early childhood education (OTEEC): Developing a population-focused, place-based approach to early intervention through occupational therapy and early childhood education center partnerships

ABSTRACT Occupational therapy practices supporting population health are emphasized in the American Occupational Therapy Association’s Vision 2025 statement, yet limited examples of how practitioner’s design, construct, and evaluate health promotion practices exist in the literature. This manuscript describes how occupational therapy providers collaborated with early childhood education administrators, teachers, and parents to create a novel approach to supporting young children’s development and learning called the Occupational Therapy Embedded in Early Childhood Education (OTEEC) Partnership Model. Educational design research informed how the OTEEC Partnership Model was developed and refined via the integration of scientific inquiry within the context of program development. We completed literature reviews, conducted in-depth interviews with key decision-makers, hosted stakeholder focus groups, and engaged in critical reflection as an occupational therapy provider team to arrive at the foundational principles and unique practices of the OTEEC Partnership Model. Early childhood education center administrators, teachers, and parents believed the strengths of the OTEEC Partnership Model included universal access to an occupational therapy provider, collaborative partnerships with teachers and parents, and integrating occupational therapy practices within an early childhood classroom context. Occupational therapy providers can use the procedures described in this manuscript to develop innovative practices focused on population health and may consider if elevating their own classroom involvement, interprofessional collaboration, and partnerships with parents can enhance their current practices. Occupational therapists may also consider how to create new access pathways for children who might benefit from occupational therapy yet do not qualify for services within current practice guidelines.

Does Green Finance Enhance the Ecological Value Level of Cultivated Land? Evidence from Mainland China

The ecological value of cultivated land contributes to a harmonious agricultural environment. Green finance support is essential to promoting the ecological value of cultivated land. Nevertheless, research specifically centered on cultivated land as a primary focus remains limited in exploring the relationship between ecological value and green finance, ignoring the fact that green finance can bolster ecological functions and drive sustainable practices. To address this gap, an objective indicator of the cultivated land ecological value level was introduced, and its variations at both the provincial and national levels from 2003 to 2022 were investigated. Results indicate that the cultivated land ecological value level increased over time, with higher values clustering spatially in southern regions. Subsequently, specific spatial correlations between the cultivated land ecological value level and green finance support were revealed using a spatial Durbin model. The results show that green finance support enhanced the cultivated land ecological value level, with its spatial lag term being particularly pronounced. These correlations were evident in eastern regions but were insignificant in western regions. Furthermore, a detailed range of spatial indirect spillover effects was estimated, demonstrating that the spatial effects on other provinces were positive when the geographic distance between them was close. In summary, these conclusions offer practical recommendations for the eco-friendly management of cultivated land, including strategies for vertical collaboration between central and local administrations and horizontal adaptation by governments in the east, central, and west regions based on local conditions.

Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats

Recent studies indicate that central administration of oxytocin (OT) reduces body weight (BW) in high fat diet-induced obese (DIO) rodents by reducing energy intake and increasing energy expenditure (EE). Previous studies in our lab have shown that administration of OT into the fourth ventricle (4V; hindbrain) elicits weight loss and stimulates interscapular brown adipose tissue temperature (TIBAT) in DIO rats. We hypothesized that OT-elicited stimulation of sympathetic nervous system (SNS) activation of IBAT contributes to its ability to activate BAT and reduce BW in DIO rats. To test this, we determined the effect of disrupting SNS activation of IBAT on OT-elicited stimulation of TIBAT and reduction of BW in DIO rats. We first confirmed that bilateral surgical SNS denervation to IBAT was successful based on having achieved ≥60% reduction in IBAT norepinephrine (NE) content from DIO rats. NE content was selectively reduced in IBAT by 94.7 ± 2.7, 96.8% ± 1.8% and 85.9% ± 6.1% (p < 0.05) at 1, 6 and 7 week post-denervation, respectively, and was unchanged in liver or inguinal white adipose tissue. We then measured the impact of bilateral surgical SNS denervation to IBAT on the ability of acute 4V OT (1, 5 µg) to stimulate TIBAT in DIO rats. We found that the high dose of 4V OT (5 µg) stimulated TIBAT similarly between sham and denervated rats (P=NS) and that the effects of 4V OT to stimulate TIBAT did not require beta-3 adrenergic receptor signaling. We subsequently measured the effect of bilateral surgical denervation of IBAT on the effect of chronic 4V OT (16 nmol/day) or vehicle infusion to reduce BW, adiposity, and energy intake in DIO rats. Chronic 4V OT reduced BW gain by −7.2 ± 9.6 g and −14.1 ± 8.8 g in sham and denervated rats (p < 0.05 vs. vehicle treatment), respectively, and this effect was similar between groups (P=NS). These effects were associated with reductions in adiposity and energy intake (p < 0.05). Collectively, these findings support the hypothesis that sympathetic innervation of IBAT is not required for central OT to increase BAT thermogenesis and reduce BW gain and adiposity in male DIO rats.

Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury.

In the present study, we examined whether chronic intracerebroventricular (ICV) leptin administration protects against ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Twelve-week-old male rats were implanted with an ICV cannula into the right lateral ventricle, and 8-10 days after surgery, leptin (0.021 µg/h, n = 8) or saline vehicle (0.5 µL/h, n = 8) was infused via osmotic minipump connected to the ICV cannula for 12 days. On day 8 of leptin or vehicle infusion, rats were submitted to unilateral ischemia/reperfusion (UIR) by clamping the left pedicle for 30 min. To control for leptin-induced reductions in food intake, the vehicle-treated group was pair-fed (UIR-PF) to match the same amount of food consumed by leptin-treated (UIR-Leptin) rats. On the 12th day of leptin or vehicle infusion (fourth day after AKI), single-left kidney glomerular filtration rate (GFR) was measured, blood samples were collected to quantify white blood cells, and kidneys were collected for histological assessment of injury. UIR-Leptin-treated rats showed reduced right and left kidney weights (right: 1,040 ± 24 vs. 1,281 ± 36 mg; left: 1,127 ± 71 vs. 1,707 ± 45 mg, for UIR-Leptin and UIR-PF, respectively). ICV leptin infusion improved GFR (0.50 ± 0.06 vs. 0.13 ± 0.03 mL/min/g kidney wt) and reduced kidney injury scores. ICV leptin treatment also attenuated the reduction in circulating adiponectin levels that was observed in UIR-PF rats and increased the circulating white blood cells count compared with UIR-PF rats (16.3 ± 1.3 vs. 9.8 ± 0.6 k/µL). Therefore, we show that leptin, via its actions on the central nervous system, confers significant protection against major kidney dysfunction and injury in a model of ischemia/reperfusion-induced AKI.NEW & NOTEWORTHY A major new finding of this study is that chronic activation of leptin receptors in the CNS markedly attenuates acute kidney injury and protects against severe renal dysfunction after ischemia/reperfusion, independently of leptin's anorexic effects.

Behavioral weight loss interventions in college health centers: A qualitative analysis of barriers and facilitators to implementation.

Emerging adults are underrepresented in standard behavioral weight loss interventions (BWLIs). Offering BWLIs in college health centers may help to address obesity in emerging adulthood by reducing student barriers associated with participation; however, implementation barriers and facilitators for health centers are unknown. Health services center administrators and providers (n=14) and students eligible to participate in a BWLI (n=9, average BMI=29.8±4.2kg/m2) participated in semi-structured interviews. Interviews focused on the need for and appropriateness of BWLIs in health centers and perceived barriers and facilitators to their implementation. Participants generally believed that BWLIs delivered through a health center were appropriate and indicated that BWLIs would be a beneficial offering on-campus. Facilitators of health center implementation included availability of trained health professionals, intradepartmental relationships, supportive infrastructure and resources, and in-house planning and execution. Barriers included limited student use and knowledge of health center offerings, narrow referral/recruitment pathways related to stigma concerns, and challenges related to infrastructure, resources, and competing demands. College health centers are a feasible and appropriate setting to offer BWLIs, though barriers to implementation exist. It will be important to construct a plan for implementation to address unique barriers in health centers prior to BWLI implementation.

The Technical Assistance (TA) Effectiveness Logic Model: A Tool for Systematically Planning, Delivering, and Evaluating TA.

Technical assistance (TA) is a tailored approach to capacity building that has grown in use across diverse settings over the past two decades, particularly in the domains of health improvement, child welfare, youth development, and education. In practice, TA services often include a combination of activities (e.g., coaching, professional development, site visits, and resource sharing) and vary in dosage, modality, and numerous other dimensions. While tailoring to recipient needs holds significant value, the individualized nature of TA creates challenges for assessing the effectiveness of TA. The difficulty of determining what contributes to TA outcomes is amplified when TA delivery is largely reactive (rather than proactive) and unaccompanied by a systematic approach to planning, delivery, and evaluation. Logic models are a well-established tool and a straightforward way to make TA more systematic. In this article, we introduce the TA Effectiveness Logic Model as a skeletal framework to guide systematic TA planning, delivery, and evaluation. The TA Effectiveness Logic Model graphically presents the rationale and expectations for how TA works in a setting. We describe two types of TA effectiveness logic models: basic and contextual. In addition, we offer a case example from work based on a national training and TA center to illustrate both types of logic models. Lastly, we discuss practical implications of TA effectiveness logic models for TA collaborators (funders, training and TA center administrators, TA providers, TA recipients, and researchers). Routinizing the use of TA effectiveness logic models has benefits for both the science and practice of TA.

Angiotensin 1-7 injected into the rat paraventricular nucleus of hypothalamus increases blood pressure and heart rate via various receptors.

Although angiotensin 1-7 (Ang 1-7) and its role as a part of the "protective" axis of the renin-angiotensin system are well described in the literature, the mechanisms of its angiotensin II-like pressor and tachycardic effects following its acute central administration are not fully understood. It was the aim of the present study to examine which receptors contribute to the aforementioned cardiovascular effects. Ang 1-7 and antagonists for glutamate, GABA, vasopressin, thromboxane A2 (TP), α1-adrenergic, and P2X purinoceptors or modulators of oxidative stress were injected into the paraventricular nucleus of the hypothalamus (PVN) of urethane-anesthetized male Wistar rats. Acute injection of Ang 1-7 into the PVN increased blood pressure (BP) by about 15 mmHg and heart rate (HR) by about 14 beats/min. After preinjection with bicuculline (GABAA receptor antagonist), CNQX + D-AP5 (AMPA/kainate and NMDA receptor antagonists) and SQ29548 (TP receptor antagonist) the BP and HR reactions to Ang 1-7 were attenuated or abolished. The vasopressin V1A and V1B receptor antagonists conivaptan and nelivaptan, and the NADPH oxidase inhibitor apocynin even reversed the pressor and tachycardic effects of Ang 1-7. Antagonists of P2X (PPADS) and α1-adrenergic receptors (prazosin), the free radical scavenger tempol and the superoxide dismutase inhibitor DETC did not modify the cardiovascular effects of Ang 1-7. The (Mas receptor-related) rise in BP and HR evoked by Ang 1-7 administered to the rat PVN is linked to glutamate, vasopressin, GABAA and thromboxane receptors, and to oxidative stress, but does not seem to involve α1-adrenergic or P2X receptors.

Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake.

Oxytocin (OT) is a neuropeptide produced in the paraventricular (PVH) and supraoptic (SON) nuclei of the hypothalamus. Either peripheral or central administration of OT suppresses food intake through reductions in meal size. However, pharmacological approaches do not differentiate whether observed effects are mediated by OT neurons located in the PVH or in the SON. To address this, we targeted OT neuron-specific designer receptors exclusively activated by designer drugs (DREADDs) in either the PVH or SON in rats, thus allowing for evaluation of food intake following selective activation of OT neurons separately in each nucleus. Results revealed that DREADDs-mediated excitation of PVH OT neurons reduced consumption of both standard chow and a high fat high sugar diet (HFHS) via reductions in meal size. On the contrary, SON OT neuron activation had the opposite effect by increasing both standard chow and liquid sucrose consumption, with the former effect mediated by an increase in meal size. To further examine the physiological role of OT neurons in eating behavior, a viral-mediated approach was used to silence synaptic transmission of OT neurons separately in either the PVH or SON. Results from these studies revealed that PVH OT neuron silencing significantly increased consumption of HFHS by increasing meal size whereas SON OT neuron silencing reduced chow consumption by decreasing meal size. Collectively these data reveal that PVH and SON OT neurons differentially modulate food intake by either increasing or decreasing satiation signaling, respectively.

Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors

Studies conducted on mammalian models have indicated the role of galanin-like peptide (GALP) in appetite regulation. For the first time, the present study examines the effects of this peptide on feed consumption and behavioral changes, as well as its interaction with dopaminergic and neuropeptide Y (NPY) systems in broilers. In experiment 1, broilers were injected with GALP (0.5, 1, and 2 μg) and saline. In experiment 2, saline, NPY1 receptor antagonist (BIBO-3304), GALP (2 μg), and BIBO-3304 + GALP were administrated. Experiments 3–6 were identical to experiment 2, except that NPY2 receptor antagonist (BIIE 0246), NPY5 receptor antagonist (CGP 71683A), D1 receptor antagonist (SCH39166), and D2 receptor antagonist (L-741,626) were injected instead of BIBO-3304. After that, cumulative meal consumption was recorded for 2 h. Also, behavioral changes in the broilers receiving GALP (0.5, 1, and 2 μg) were monitored for thirty minutes after infusion. Following the administration of GALP (1 and 2 μg), food intake and the number of feeding and exploratory pecks of chicks increased (P < 0.05), while other behaviors did not change significantly (P ≥ 0.05). Co-infusion of BIBO-3304 + GALP suppressed the orexigenic effect of GALP (P < 0.05). Infusion of BIIE 0246, CGP 71683A, and L-741,626 with GALP, had no significant effect on GALP-induced hyperphagia (P ≥ 0.05). However, the orexigenic effects of GALP were stimulated following the co-administration of SCH39166A + GALP (P < 0.05). These findings indicate that NPY1 and D1 receptors can mediate GALP-induced hyperphagia in broilers.

Central treatment of neuropeptide-S attenuates cognitive dysfunction and hippocampal synaptic plasticity impairment by increasing CaMKII/GluR1 in hemiparkinsonian rats

Neuropeptide-S (NPS) has been demonstrated to mitigate learning and memory deficits in experimental models of Parkinson’s Disease (PD). Despite this, the precise mechanisms through which NPS exerts its influence on cognitive functions remain to be fully unknown. This study aims to elucidate the effects of central administration of NPS on learning and memory deficits associated with an experimental rat hemiparkinsonian model, examining both electrophysiological and molecular parameters. The hemiparkinsonian model was established via stereotactic injection of 6-hydroxydopamine (6-OHDA) into the right medial forebrain bundle. Central NPS (1 nmol, icv) was administered into the lateral ventricle via a cannula for seven consecutive days following the 6-OHDA lesion. The Morris water maze and object recognition tests were used to evaluate the rat’s learning and memory abilities. Long-term potentiation (LTP) recordings were conducted to assess hippocampal synaptic plasticity. Immunohistochemistry was employed to determine the expression levels of phosphorylated CaMKII (pCaMKII), GluR1, and GluR2 in the hippocampus. The 6-OHDA-induced decline in cognitive performance was significantly (p < 0.05) improved in rats that received central NPS. In 6-OHDA-lesioned rats, NPS treatment significantly (p < 0.05) enhanced the amplitude of LTP at the dentate gyrus/perforant path synapses. Furthermore, NPS significantly (p < 0.05) increased the number of pCaMKII and GluR1 immunoreactive cells in the hippocampus, which had been diminished due to 6-OHDA, except for GluR2 levels. These findings provide insight into the mechanisms by which central NPS administration enhances cognitive functions in an experimental model of PD, highlighting its potential therapeutic benefits for addressing cognitive deficits in PD.

Simulators for Conversing Power to Thermal on Green Data Centers: A Review

This paper aims to help data center administrators choose thermal simulation tools, which manage thermal conduction from power for energy savings. When evaluating and suggesting data center thermal simulators for users, questions such as “What are the simulator’s differences? Are they easy to use? Which is the best choice?” are frequently asked. To answer these questions, this paper reviews the thermal simulation works for data centers in the last ten years. After that, it proposes the versatility and dexterity metrics for these simulators and discovers that it is difficult to choose them despite their similar design purpose and functions. Empowered by the survey, we claim that the widespread practice simulators still need more enhancement in data center scenarios. We back up our claim by comparing typical simulators and propose improvements to thermal simulators for future studies.

The State of the Union: A History of the Labor Movement at Vanderbilt University

This article will document the historical context of the labor movement at Vanderbilt University in order to explain the nature and interaction of the labor union with central administration over the past forty years. Recognizing the lack of scholarly attention to the labor movement in Paul Conkin’s Gone with the Ivy (1985) and Peabody College (2002) and Dale Johnson’s Vanderbilt Divinity School (2001), the author contributes to the academic literature by providing a broad overview of the historical background and current state of the labor movement. As the largest employer in Davidson County and a major contributor to the state of Tennessee’s economic development, the relationship of University administrators and labor representatives has a large impact on the condition of surrounding labor movements, particularly in the city of Nashville’s low-wage service workers sector. In providing a brief chronological synopsis of the labor movement and the role of female involvement in the union, the author concludes by providing a context for contemporary labor negotiations.

DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral Administration.

The development of opioid analgesics with reduced adverse effects is an unmet need. In a previous study, we discovered a unique combination of BPRMU191 and morphinan antagonists that produced potent antinociception with reduced adverse effects after central administration (intrathecal or intracerebroventricular). BPRMU191/naltrexone exhibits notable in vitro and in vivo pharmacological properties. However, the poor blood-brain barrier penetrative ability of BPRMU191 restricts its clinical application. In this study, we utilized a prodrug strategy to deliver sufficient brain concentrations of BPRMU191 and selected compound 2 (DBPR116) with the best physicochemical and pharmacological properties among other in vivo active prodrugs. The in vivo pharmacological studies of compound 2/naltrexone, including thermally stimulated pain, cancer pain, constipation, sedation, psychological dependence, heart rate, and respiratory frequency measurements, demonstrated that it was a safer opioid analgesic than morphine in pain control.

The multi-dimensionality of citizen satisfaction: A conjoint experimental approach

Current research demonstrated that many factors affect public satisfaction of government services. One central challenge for scholars is that citizen satisfaction is a multi-dimensional concept, yet most empirical tests focus on a small number of factors, and do not account for the simultaneous effects of the many factors. In this study, we present a comprehensive approach that accounts for this multi-dimensionality, and views satisfaction as dependent on two categories of factors: service-specific attributes, and performance comparisons. We assess the multi-dimensional nature of citizen satisfaction with a conjoint experiment, a methodological tool that allows us to test the causal effect of multiple factors operating at the same time. We use the conjoint design to investigate citizen satisfaction from every-day government services. The findings suggest that citizen satisfaction is driven by both groups of variables. Also, we find evidence for a negativity bias in public evaluations when service-specific attributes are involved: individuals' reported satisfaction is more sensitive to negative information like higher costs or unprofessional behavior by service providers compared to positive description of these factors. At the same time, we find that factors in the performance comparisons category create more balanced effects on satisfaction with respect to the information valence. The analysis reveals the drivers of public satisfaction of government services and the importance of key factors. The use of a conjoint design provides a more appropriate tool to tackle the multi-dimensional nature of a central public administration concept of citizen satisfaction.