Center Paradigm Research Articles

Towards a unified ontology for IoT fabric with SDDC

The ever growing Internet of Things (IoT) paradigm aims to put people’s incorporation into the new phase of connectivity and sensor technology. While, IoT has the potential to deliver new value-added services in order to make life easier and healthier for people, there are still several issues to be addressed in order to harness the widespread dissemination and adoption of the IoT paradigm, considering its potential benefits. In this context, considering an IoT ecosystem holistically i.e. end-to-end which includes the proprietary Operational Technology (OT) comprising of software and hardware to monitor, detect and control the equipment through sensors and actuators and the general Information Technology (IT) which comprises of the data center infrastructure catering to the backend needs of IoT such as compute, storage and network, one major challenge is converging OT with IT. Such an OT/IT convergence has the potential to explore many problems that exist in the end-to-end IoT ecosystem. One such problem is related to drawing actionable insights through operational analytics. The data center paradigm which concerns this research is the Software-Defined Data Center (SDDC) which is touted as the preferred data center paradigm for IoT. While most of the research happening on IoT today deals with the data from the IoT applications and sensors, this research focuses on the plethora of the metadata contained in the end-to-end IoT ecosystem. This research demonstrates the modelling of the end-to-end IoT ecosystem using semantic-based approach such as ontology. We arrive at a cohesive unified ontology unifying the OT and the IT constituents of the IoT fabric with SDDC together with rich context aware attributes embedded in the unified ontology, thereby addressing the problem of OT/IT convergence as well as laying the foundation to explore many solutions to problems pertinent in such a converged OT/IT ecosystem.

Valsartan/Sacubitril for Treatment of Hfref: A Single Center's Paradigm

PARADIGM-HF compared valsartan/sacubitril (ARNI) with enalapril in symptomatic patients with heart failure with reduced ejection fraction (HFrEF) (1). It was stopped early after the boundary for overwhelming benefit in favor of ARNI had been reached. Patients taking ARNI had decreased symptoms, risk of HF hospitalization and all-cause and cardiovascular mortality. We sought to describe our center’s initial year of experience with this novel agent. A retrospective chart review was completed of all patients in our advanced HF clinic who were prescribed ARNI between August 2015 and October 2016. Outcomes data were collected through August 2017. Consistent with the Food and Drug Administration (FDA) indication, patients treated had NYHA class II, III or IV HF symptoms with LVEF of 35% or less. The majority of those prescribed ARNI were able to initiate the medication. However, a significant proportion of patients (26.4%) had to discontinue ARNI due to a variety of reasons, most commonly symptomatic hypotension (31.0%) and insufficient insurance coverage (31.0%). Only 30.5% of patients successfully treated reached the maximum dose; in 85% of these patients, hypotension limited up titration of therapy. PARADIGM-HF demonstrated benefit of ARNI therapy over enalapril in patients with HFrEF and therapy was well tolerated. In our real world experience, hypotension and lack of insurance coverage limited utilization. Further experience with this therapy in a non-trial setting will inform optimal patient selection and titration strategies. Expanded insurance coverage will be crucial to allow for patient access.

Optimal transfer paradigm for emergent large vessel occlusion strokes: recognition to recanalization in the RACECAT trial

Of the various forms of stroke, emergent large vessel occlusion (ELVO) stroke produces the majority of disability and death after stroke,1 but now represents a target for highly efficacious endovascular...

Standardization Efforts for Traditional Data Center Infrastructure Management: The Big Picture

Traditional data center infrastructure suffers from a lack of standard and ubiquitous management solutions. Despite the achieved advances, existing tools lack interoperability and are sometimes hardware dependent. Vendors are already actively participating in the specification and design of new standard software and hardware interfaces within different forums. Nevertheless, the complexity and variety of data center infrastructure components that includes servers, cooling, networking, and power hardware, coupled with the introduction of the software defined data center paradigm, led to the parallel development of a myriad of standardization efforts. In an attempt to shed light on recent works, we survey and discuss the main standardization efforts for traditional data center infrastructure management.

Effect of routing paradigm on patient centered outcomes in acute ischemic stroke

BackgroundTo compare performance of routing paradigms for patients with acute ischemic stroke using clinical outcomes.MethodsWe simulated different routing paradigms in a system comprising one primary stroke center (PSC) and one...

Playing with Arts and Identity in Koffi Kwahulé’s Recent Theatre: Basquiat and Fela Kuti

“Playing With Arts and Identity in Koffi Kwahulé’s Recent Theatre: Basquiat and Fela Kuti” situates Kwahulé’s theatre within the trajectory of Francophone African theatre that queries notions of identity and politics. It sees Kwahulé’s work as part of a movement that turns away from questions of colonization and decolonization to trouble the center and periphery paradigm of postcoloniality. Kwahulé adds a transnational dimension, especially through the use of jazz motifs. He constructs in his plays an identity in constant motion, an identity that refuses borders and transforms through contact and improvisation. In recent works, notably the focus of this essay, SAMO: A Tribute to Basquiatand Kalakuta Dream: A Tribute to Fela Kuti (both written in 2015), Kwahulé incorporates jazz and rap strategies of scrambling lines, repeating phrasing, riffing while rhyming, and syncopation to capture textually the particular aesthetics of both artists. Through musicality, Kwahulé grasps the vibrancy and collage techniques in Jean-Michel Basquiat’s canvases. SAMO thus becomes not only an exploration of Basquiat’s hybrid identity but also a theatrical transposition of how Basquiat’s paintings “speak.” Kalakuta Dream, more a surreal sketch than aplay, invites actors, dancers, and musicians to realize a political commentary through instrumentation.Kwahulé’s Fela Kuti, iconoclastic and gutsy, dreaming of another, and freer, universe in his Kalakuta “Republic,” skewers dictatorial power through irreverent behavior,including trenchant music.Innovative and challenging, both plays foreground the feints and dodges necessary to survive an increasingly materialistic world.

Effect of routing paradigm on patient-centered outcomes in acute ischemic stroke

This article has been retracted

Polish listeners’ perception of vowel inherent spectral change in L2 English

Abstract This paper describes a perception experiment with Polish listeners involving vowel inherent spectral change (VISC) in L2 English. A forced-choice rhyming task employing the Silent Center (SC) paradigm revealed relatively uniform effects of stimulus type (SC, Initial, Middle, Final) on accuracy across two proficiency groups, despite greater overall accuracy on the part of the more proficient users. Analysis of individual vowel pairs used in the rhyming trials revealed some effects of proficiency on the degree to which formant movement in the stimuli affected identification accuracy. This research contributes to the relatively sparse literature on VISC in L2 acquisition. Phonological considerations underlying the degree of VISC in Polish and English are also discussed.

INSTITUSIONALISASI PARADIGMA REVENUE CENTER UNTUK PENGELOLAAN ASET NEGARA YANG OPTIMAL (STUDI KASUS PADA KANTOR PELAYANAN KEKAYAAN NEGARA DAN LELANG SURABAYA)

To realize good and accountable asset management, the Ministry of Finance as CFO (Chief Financial Officer) sets the revenue center paradigm in asset management. This is a new breakthrough from before that just as an asset administrator turns into asset manager without thinking about the potential revenue from asset management. The Directorate General of State Assets (DJKN) as the state asset manager with vertical institutions is implementing National Working Meeting (Rakernas) as the milestone of the beginning of the birth of this new paradigm with the stipulation of Circular Letter (Surat Edaran) Number 2/KN/2016 about the Following of the National Working Meeting DJKN 2016. Based on the mandate, The State Property and Auction Office of Surabaya (KPKNL Surabaya) continues to internalize this paradigm shift in order to realize the optimization of revenue through the management of state assets. The purpose of this study is to understand how the institutionalization process of this new paradigm by using new institutionalism theory. The methodology used in this research uses qualitative method with case study approach which is discussed with deep descriptive analysis. The results indicate the existence of institutional isomorphism symptoms that occur in the internalization process of this new paradigm, thus providing an overview of the influence and reaction to the establishment of a new paradigm that encourages organizational change.

Spectral dynamics in L1 and L2 vowel perception

This paper presents a study of L1 and L2 vowel perception by Polish learners of English. Employing the Silent Center paradigm (e.g. Strange et al. 1983), by which listeners are presented with different portions of a vowel, a force choice identification task was carried out. Due to differences in the vowel systems of the two languages, it was hypothesized that stimulus type should have minimal effects for L1 Polish vowel perception since Polish vowels are relatively stable in quality. In L2 English, depending on proficiency level, listeners were expected to adopt a more dynamic approach to vowel identification and show higher accuracy rates on the SC tokens. That is, listeners were expected to attend more to dynamic formant cues, or vowel inherent spectral change (VISC; see e.g. Morrison and Assmann 2013) in vowel perception. Results for identification accuracy for the most part were consistent with these hypotheses. Implications of VISC for the notion of cross-language phonetic similarity, crucial to models of L2 speech acquisition, are also discussed.

Under-Body Blast Mitigation: Stand-Alone Seat Safety Activation System

This work is based on a current project funded by the United States Army Small Business Innovation Research (SBIR) Program and is being conducted with the Tank Automotive Research, Development and Engineering Center (TARDEC) Ground Systems Survivability (GSS) Team and Paradigm Research and Engineering. The focus of this project is to develop an advanced and novel sensing and activation strategy for Pyrotechnic Restraint Systems, Air Bags and other systems that may require activation. The overriding technical challenge is to activate these systems to effectively protect the Soldier during blast events in addition to Crash, Rollover and Other Injury Causing events. These activations of Pyrotechnic systems must occur in fractions of milliseconds as compared to typical automotive crashes. By investigating systems outside of typical accelerometer based applications and activations, the potential exists to exploit systems that require little power, are self-contained and provide the required output for the desired result. As such Constant-Flux Magnetostrictive Sensors shall be evaluated in a self-contained environment to provide the output during these events. By activating the Pyrotechnic Restraint Systems and Air Bag Systems early in Blast Events, the systems can Restrain the Occupant and provide flail protection from surfaces within the vehicle. As the system is developed various test scenarios will be introduced to activate these systems and design a robust sensing and activating strategy. Language: en

A burn center paradigm to fulfill deferred consent public disclosure and community consultation requirements for emergency care research

IntroductionTo fulfill Food and Drug Administration and Department of Health and Human Services emergency care research informed consent requirements, our burn center planned and executed a deferred consent strategy gaining Institutional Review Board (IRB) approval to proceed with the clinical study. These federal regulations dictate public disclosure and community consultation unique to acute care research. ObjectiveOur regional burn center developed and implemented a deferred consent public notification and community consultation paradigm appropriate for a burn study. MethodsPublished accounts of deferred consent strategies focus on acute care resuscitation practices. We adapted those strategies to design and conduct a comprehensive public notification/community consultation plan to satisfy deferred consent requirements for burn center research. ResultsTo implement a robust media campaign we engaged the hospital's public relations department, distributed media materials, recruited hospital staff for speaking engagements, enlisted community volunteers, and developed initiatives to inform “hard-to-reach” populations. The hospital's IRB determined we fulfilled our obligation to notify the defined community. ConclusionOur communication strategy should provide a paradigm other burn centers may appropriate and adapt when planning and executing a deferred consent initiative.

A specialized team approach to diagnosis and medical versus surgical treatment of infants with congenital hyperinsulinism

Hyperinsulinism (HI) is the most common cause of transient and permanent forms of hypoglycemia in infancy. Establishing the correct diagnosis and initiating appropriate therapy without delay is of utmost importance. Once the diagnosis is made and if medical therapy with diazoxide fails, one should assume that the infant has a K(ATP) channel defect and may require surgery. In this case, the infant should be referred to a center that specializes in HI with 18-fluoro L-3,4-dihydroxyphenylalanine positron emission tomography scan. This report describes a center specializing in HI with a team of experts consisting of endocrinologists, nurse practitioners, geneticists, radiologists, pathologists, and a surgeon. It describes the center's paradigm for managing severe HI on the basis of more than 250 cases of HI in the past 10 years, including the diagnosis of HI, medical options, genetics of HI, imaging in HI, the surgical approach to HI, and outcomes.

Comprehensive Services for At-Risk Urban Youth: Applying Lessons From the Community Mental Health Movement

Despite the serious problems faced by urban minority youth, services provided to such youth remain fragmented and uncoordinated. In this article we examine lessons learned from the community mental health movement in addressing the needs of a similarly disenfranchised population, individuals with psychiatric disabilities. A model alternative school intervention program is presented that draws on strategies developed within a community mental health center paradigm to provide a comprehensive model of service delivery to youth based on prevention strategies, a positive youth development approach, and culturally appropriate interventions derived in collaboration with the population served. Despite the lessons learned and progress made in servicing this multiproblem population, further work is needed to achieve full integration of school interventions and their home communities.

Perception of coarticulated vowels by prelingual infants: Formant transitions specify vowel identity

German-learning infants were tested for discrimination of four German vowel contrasts in the Silent Center paradigm to examine which acoustic properties of coarticulated vowels (target-spectral, dynamic-spectral) define vowel identity in prelingual infants. Acoustic analyses of naturally produced original syllables (/dVt/ with V=/i, e, I, E, o, U/) revealed no vowel inherent spectral change but only formant movement associated with the gestures for the initial and final consonants. The original syllables were electronically modified to obtain test syllables which contained target-spectral information (the vowel nucleus only), only initial or only final formant transitions, or initial and final transitions in their appropriate temporal relationship, with the vowel nucleus attenuated to silence. Four groups of ten infants each (aged 7–11 months) were tested in the conditioned headturn procedure for discrimination of the test syllables. Each group was tested on one of four contrasts (/i/–/e/, /e/–/I/, /E/–/I/, /o/–/U/) after they had discriminated that contrast successfully in the unmodified condition. Results indicate that target spectral information is not needed to discriminate native contrasts; rather, dynamic spectral information spread over syllable onsets and offsets is sufficient to specify vowel identity in infants. [Work supported by grants of the Deutsche Forschungsgemeinschaft to O.-S. Bohn.]

Innovative Perspectives on Health Services for Vulnerable Rural Populations

Health problems for which individuals, families, and communities are at risk are exacerbated in sparsely populated, geographically remote, rural areas. Vast distances limit access to essential health services. The University of North Dakota Nursing Center's paradigm of population-specific, family-focused, community- based services directed toward primary prevention and care during chronic illness is proposed as an effective perspective for rural health care delivery. Based fundamentally on an agricultural metaphor, the center is grounded in an ecologic understanding of the health and illness experiences of vulnerable rural populations, with a primary emphasis on nursing case management for improved care in a system of managed cooperation. Sources of reimbursement for services are varied, including grants, contracts, and fees. Evaluation focuses on outcomes of individuals, families, and communities to ensure that services are responsive to meeting health needs of vulnerable rural populations.