Research Institute Research Articles

FoCa – Free of Carbon Architecture –an educational and informational online platform supporting the decarbonization of the construction sector in Poland and Turkey

Wrocław University of Science and Technology, in consortium with the Polish Association of Ecological Buildings (PLGBC), the Institute of Building Technology (ITB) and research and scientific units from Turkey, started the international project FoCA – Free of Carbon Architecture. Its aim is to create a publicly available tool – an interactive internet platform providing information on the environmental properties of construction materials and products available in Poland and Turkey. The platform allows users to compare and evaluate the environmental impact of selected building materials. As part of the platform's development, information is collected about building materials or products available on local markets, in the form of data describing their selected environmental impacts (GWPfossil, GWPbiogenic, GWPtotal, TRPE, TNRPE, WD). The platform allows to compare building materials and perform analyzes for conceptual building designs. In addition, producers of building materials can also benefit from the project because they will receive information about the environmental properties of some of their products. The platform will be available in the second half of 2024.

The Role of Business Incubators in Encouraging Maritime Technology Start-up Innovation

This study examines the critical role of business incubators in driving innovation in maritime technology start-ups. With the growing need for innovative technology solutions in the maritime industry, business incubators have emerged as a key catalyst in developing and introducing new ideas to the market. The study used a qualitative approach, involving in-depth interviews with 30 stakeholders, including start-up founders, incubator managers, and maritime industry experts. The results showed that business incubators provide critical support in the form of access to funding, expert mentoring, research and development facilities, and extensive industry networks. The findings also revealed that incubators that focus on the maritime sector are more effective in helping start-ups overcome industry-specific challenges. The study highlights the importance of collaboration between incubators, the maritime industry, and educational institutions to create an ecosystem that supports innovation. Implications of this study include recommendations for policymakers and industry players in designing more effective incubation programs to drive maritime technology innovation.

Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64

Aim. To study the possible relationship between personal anxiety and polymorphic variants of genes associated with eating disorders (rs17782313 MC4R, rs1800497 DRD2, rs9939609 FTO) in women aged 45-64 in Novosibirsk.Material and methods. A random representative sample of women aged 45-64 years (n=1074, mean age, 54,27±0,2 years) was examined in 2003-2005 at the Research Institute of Internal and Preventive Medicine, a branch of the Institute of Cytology and Genetics, within the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) project. Personal anxiety was assessed using the Spielberger self-assessment questionnaire included in the protocol of the Multinational Monitoring of Trends and Determinants of Cardiovascular Disease — Optional Psychosocial Study (MONICA-MOPSY), tested at screenings of the World Health Organization (WHO) MONICA program in 1983-1995. The sample for the HAPIEE program was formed at the program data processing center in Prague for each of the collaborating centers in such a way that each respondent was random. From the sample, every second woman (n=537) was selected for genotyping of the FTO rs9939609 variant (n=384); every third woman (n=358) — for genotyping the MC4R rs17782313 (n=279) and DRD2 rs1800497 variants (n=327). Genotyping was performed in the laboratory of molecular genetic studies by the polymerase chain reaction with the analysis of restriction fragment length polymorphism.Results. Among women aged 45-64, anxiety was detected in 58,3%, and in 15,9% of women the anxiety level was high. The homozygous genotype C/C rs17782313 of the MC4R gene was more common among women with high anxiety levels (17,5%) than among women with low and moderate anxiety levels (1,8 and 0,8%, respectively; p=0,001). There were no significant differences in the detection rate of the rs1800497 genotypes of the DRD2 gene among women with different levels of anxiety (p>0,05). The frequency of the A/A rs9939609 genotype of the FTO gene was highest among women with high anxiety levels — 29,5%, compared to participants with low and moderate anxiety levels (15 and 15,3%, respectively; p=0,048). The probability of anxiety among carriers of the C/C+C/T genotypes of the MC4R gene was 1,29 times higher than among carriers of the T/T genotype (p=0,001). Among carriers of the A/A rs9939609 genotype of the FTO gene, the anxiety probability was 2,34 times higher than among carriers of the A/T+T/T genotypes (p=0,008).Conclusion. The association between anxiety and genes of eating disorders dictates the need for diagnosis and subsequent treatment of anxiety and its associated consequences.

Hengniu: Fast Bearing and High Yielding Coconut Varieties

Benefits of coconut varieties that stakeholders want are early bearing, high yielding, short stems, and slow growth for height. Most local tall coconut palms in Indonesia have stem height above 20 m, making it increasingly difficult to climb to harvest fruit or tapping sap thereby making the harvesting cost high. To breed varieties of desired characters, an evaluation trial was initiated in 2014 with BYD x MTT-S4, RAD x MTT-S4, and KHINA-1 as a control. The crossing was done in 2012 and seedlings planted in January 2014 at Mapanget Experimental Garden, Indonesian Palma Crops Research Institute, North Sulawesi. The study used a Randomized Block Design (RBD) of three types of coconut hybrids, four replications with a plot size of 16 trees. Morphological observations were carried out on stem, crown and leaf characters, inflorescences and flowers, nut production, fruit components, copra, oil content, and fatty acid composition. The results of ANOVA analysis and statistical tests obtained those vegetative characters, such as stem circumference and number of leaf, generative characters namely the number of bunches, first flowering, and fruit production of these three crosses at the age of 4 years after planting, did not show a significant difference. The first initial flowering was in the coconut hybrid of RBD x MTT-S4, which is 26 months, followed by BYD x MTT-S4 in 32 months and KHINA-1 in 36 months after planting. The results of the analysis of fruit and copra production at the age of 5 years showed a significant increase between hybrid coconuts. The highest to lowest fruit production was obtained in BYD x MTT-S4 hybrid coconut, RBD x MTT-S4, KHINA-1, which were 64 nuts, 44 nuts and 26 nuts /palm respectively, or estimated copra production was 2.26 tons, 1.45 tons and 0.88 tons copra/ha. At 6 years old the harvest of fruits from the three hybrid coconuts is obtained sequentially 118 nuts, 99 nuts and 94 nuts/palm. While estimation of copra yield per hectare is found the highest in BYD x MTT-S4 hybrid coconut is 3.86 ton/ha/year and this yield differently significant compare with RBD x MTT-S4 is found 3.04 ton/ha/year, and control hybrid of KHINA-1, which is about 2.74 ton/ha/year. Based on the production potential, hence the estimated optimum production when aged over 10 years can reach more than 5 tons/ha/year. The hybrid coconut variety BYD x MTT-S4 is released in October 2019 under the name HENGNIU.

Assessment of grain starch content and responses to CMS-S and CMS-C in high-starch maize hybrids

Background. Increasing the production of native and modified starch from maize requires raw materials with high starch content in grain. Materials and methods. An experimental panel of 780 simple high-starch maize hybrids produced with CMS-S and CMS-C lines underwent two-year testing. Starch content in the grain of the lines and their hybrids was assessed with IR spectrometry. Native starch content in the grain of hybrids with highest yields was measured at the All-Russian Research Institute of Starch and Starch-Containing Raw Materials Processing using the method proposed by L. P. Nosovskaya with coauthors. Responses to CMS were scored according to G. S. Galeev’s scale. Results. Grain starch content was found to vary from 58% to 72% DMB throughout the tested panel. IR spectrometry helped to identify 22 hybrids with high (72.03–72.67%) starch content, and 5 hybrids promising for deep grain processing, combining high protein (10.3–13.53%) and oil (3.77–5.03%) levels with high starch content (69.02–70.4%) in their grain. Native starch extraction using L. P. Nosovskaya’s method showed that grain starch content in the best 68 hybrids ranged from 70.03 to 71.95% DMB. The collection was ranked according to the main heterotic groups: 57 lines of Iowa Dent, 26 lines of Stiff Stalk Synthetic, and 28 lines of Lancaster. For CMS-S and CMS-C types, 33 and 6 maintainers, and 9 and 8 restorers were selected, respectively. The hybrids were distributed across the following FAO maturity groups for maize: FAO 200–299 (14 hybrids), FAO 300–399 (7), FAO 400–449 (21), and FAO 450–500 (29). Conclusion. Assessing agronomic and breeding prospects of the best 68 hybrids between high-starch maize lines and sterile testers proved their potential for producing native starch to at least 70–72% DMB. Five hybrids were identified as promising for yielding native starch (69.02–70.4% DMB), as well as protein (10.3–13.5% DMB) and oil (3.77–5.03% DMB) by-products during deep grain processing.

Optimization of the DNA isolation procedure for assessing the genetic diversity of essential oil roses (Rosa L.)

Background. High content of organic compounds that worsen nucleic acid purification in aromatic plants, as well as the use of such toxic substances as phenol and mercaptoethanol in many protocols for plant DNA isolation, make it advisable to take the above disadvantages into account when optimizing the DNA extraction technique for the work with essential oil rose plants. Material and methods. Rose accessions from the Crimean Federal University’s Botanical Garden, and those from the collection held by the Research Institute of Agriculture of Crimea were included in the study. DNA extraction was done according to a modified CTAB protocol. Effectiveness of the technique was assessed using spectrophotometry, horizontal electrophoresis, and ISSR-PCR. Results. DNA preparations extracted with the modified technique were well visualized on the electropherogram and demonstrated high spectrophotometric values. DNA content was twice as high in preparations isolated with an extraction buffer with PVP, compared to a PVP-free buffer. The concentration was also higher in DNA extracts from stems than that from leaves. Purity parameters expressed by the absorption ratios at wavelengths A260/280 and A260/230 were again higher for DNA extracts from stems isolated with an enriched buffer, the A260/230 ratio falling within the normal range only in DNA extracted from stems in the presence of PVP. Besides, DNA extracts were effectively purified from proteins without phenol or mercaptoethanol, due to double rinsing with a chloroform/isoamyl alcohol (24 : 1) mixture. Conclusion. Using rose stem tissues as the research material, adding 2% PVP to the extraction buffer, and twofold rinsing with a chloroform/isoamyl alcohol mixture made it possible to obtain DNA extracts with high concentrations and purity indices within normal ranges suitable for the ISSR analysis of essential oil rose genetic diversity.

Hypertension prevalence among the male population aged 35-74 years in Novosibirsk

Aim. To study the prevalence and risk factors of hypertension (HTN), structure and effectiveness of treatment coverage, as well as disease control indicators among the male population aged 35-74 years in Novosibirsk.Material and methods. This cross-sectional study of the Novosibirsk population was conducted in 2021-2023 at the Research Institute for Internal and Preventive Medicine — branch of the Federal Research Center Institute of Cytology and Genetics according to the ESSE-RF3 study protocol. A total of 1200 people aged 35-74 years living in Novosibirsk were examined. The analysis included 600 men. The response rate exceeded 70%. HTN was considered detected in systolic blood pressure (BP) ≥140 mm Hg and/or diastolic BP ≥90 mm Hg and/or in patients taking antihypertensive agents. Awareness was estimated as the proportion of individuals who had previously been informed by a physician about HTN. Treatment effectiveness was considered the proportion of individuals who achieved target BP values while taking antihypertensive therapy. Hypertension control was considered the proportion of individuals who achieved target values among all those examined with HTN. Statistical processing was performed using the SPSS software package (version 13.0). Associations were assessed using multiple logistic regression analysis. The critical significance level of the null hypothesis (p) was 0,05.Results. The medians of systolic and diastolic BP among men in No­vo­sibirsk were 136,0 [126,5; 149,5] and 89,0 [82,0; 95,5] mm Hg, respectively. The prevalence of HTN among men aged 35-74 in Novo­sibirsk was 68,9%, while 81,1% of men in Novosibirsk were aware of HTN. Among men with HTN, 54,7% take antihypertensive agents. The effectiveness of treatment among men in Novosibirsk is 32,3%, while 19,6% of men control the disease. The odds of hypertension occurrence in men with hypertriglyceridemia increased by 3,5 times, with abdominal obesity — by 2 times, with an positive family history for cardiovascular diseases — by 1,6 times, and with each year of life increased by 1,1 times.Conclusion. The prevalence of HTN among men in Novosibirsk is higher in comparison with the average Russian level. Significant risk factors for HTN include abdominal obesity, hypertriglyceridemia, and decreased physical activity. While awareness, treatment coverage, and HTN control among men aged 35-74 in Novosibirsk correspond to Russian trends, treatment effectiveness turned out to be slightly lower than in the Russian population.

Installation of percutaneous endoscopic gastrostomy for children. The tactics of a nurse

The article is based on the data and experience of the Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, obtained during endoscopic practice. Currently, the number of pediatric patients requiring installation of a percutaneous endoscopic gastrostomy is significantly increasing, due to the increase in treatment regimens and the expansion of the range of indications for its installation. PEG combines endoscopic and surgical stages. The nurse must know the difference and differences of each stage, as well as have all the basic and advanced knowledge about all indications, contraindications and any complications during and after surgery. Compliance by the nurse with all the rules of asepsis and antisepsis, knowledge of SANPIN, is the foundation of her professionalism. Interest in the process will undoubtedly influence the quality of medical care provided. The nurse must study and know all the instruments, consumables and additional materials for performing endoscopic surgery. Her clear actions and orientation in what is happening guarantees the speed and success of the manipulation. The purpose of this work will be to emphasize the importance of professional development for nurses. To achieve the goal, we use all facets of a nurse’s work: knowledge of the concept of «sterility», orientation in all stages of manipulation from preparing the room to its complete routine cleaning after the intervention, all theoretical knowledge about the reasons for installing a gastrostomy tube and free orientation in any types of complications, etc. All of the above guarantees that the operating room endoscopic nurse is interested in the process, which will undoubtedly affect the quality and convenience of the doctor’s work, and subsequently the patient’s quality of life. The main goal of the entire operating team is to improve the patient’s quality of life. Understanding the meaning of all surgical endoscopic interventions obliges the nurse to constantly improve their skills and engage in self-education.

Mixed Methods Research Centering on Minoritized Students in Higher Education: A Literature Review

AbstractThe increasing diversity among higher education students urges researchers to expand research methodologies beyond traditional quantitative approaches. A growing number of higher education researchers have employed mixed methods research (MMR) approaches in studies centering on minoritized student populations. In this review, we identified and analyzed 72 empirical MMR studies published between 2007 and 2023, describing the characteristics of the research design and focusing on the MMR design strategies employed by the authors. The review details specific MMR strategies, including methods for engaging participants, integrating quantitative and qualitative data, and advancing the research agenda that centers minoritized students. Based on the review, we discuss methodological considerations and offer recommendations for higher education professionals to advance more thoughtfully conscious, student-centered modes of knowledge production focusing on minoritized populations.

Transforming Care in SEA: Evidence and Considerations for Evolution of the Current Treatment Paradigm

This article reviews an industry symposium held on 8 September 2024 as part of the European Respiratory Society (ERS) Congress 2024 in Vienna, Austria, which brought together four experts to discuss the current treatment paradigm for severe eosinophilic asthma (SEA), including the role of biologics and background medication tapering. Katrin Milger-Kneidinger, Professor of Respiratory Medicine at the University Hospital of the Ludwig Maximilian University Munich (LMU), in Germany, and the MedUni Graz, in Austria, explored the critical role eosinophils play in SEA pathology and how biologic therapies targeting eosinophils can address key disease features, including airway remodelling, airway hyperresponsiveness (AHR), and mucus production. Felix Herth, Professor of Pulmonary and Critical Care Medicine at Thoraxklinik Heidelberg, Heidelberg University Hospital, in Germany, discussed persistent airflow obstruction (PAO) in patients with SEA, focusing on a typical patient profile to understand the clinical manifestation and opportunities for management. Stephanie Korn, Professor of Pulmonary and Respiratory Medicine at Thoraxklinik Heidelberg, Heidelberg University Hospital, in Germany, and Head of the Clinical Research Centre, Institute für Klinische Forschung (IKP) Pneumologie in Mainz, Germany, presented on remission as a clinical target in SEA, focusing on how biologics can help achieve remission in some patients. Lastly, in a discussion led by symposium chair Stefano Del Giacco, Professor of Medicine, Allergy, and Clinical Immunology, at the University of Cagliari, Sardinia, in Italy, the experts agreed that a positive practice change would be to get more patients with relevant clinical manifestations on biologics, and that background medication tapering, when appropriate, could lead to improved patient outcomes and quality of life (QoL) in SEA.

Proceedings of the 2024 Australasian Road Safety Conference - Hobart, Tasmania, Australia

Proceedings of the 2024 annual Australasian Road Safety Conference held in Hobart, Tasmania, Australia. The proceedings provide the Extended Abstracts and Posters describing research, educational and policing program implementation and policy and management strategies related to all aspects of road safety and especially related to the conference theme of Target 2030: What's the pathway forward? Almost 600 delegates from 20 countries attended the face-to-face conference. Authors of accepted Extended Abstracts represented international and local institutions from all aspects of their respective communities including research centres, private companies, government agencies and community groups. These Extended Abstracts provide an indication of the important work being done in Australia, New Zealand and internationally as part of the United Nations, One UN Vision for Road Safety to reduce the number of crashes on the road by 50 percent by 2030. Almost 200 Extended Abstract manuscripts were accepted for long, short and poster sessions. Each Extended Abstract was peer-reviewed by two experts with relevant expertise. Authors were also provided the option of submitting a Full Paper. Those authors who chose to submit a Full Paper for consideration in the Journal of Road Safety (JRS) could do so based on the outcome of the peer review of their Extended Abstract. Submitted Full Papers undergo peer-review by three independent experts matched by their sector. The matching pairs academic authors iwth academic reviewers and practitioner authors with practitioner reivewers. Inclusion in the JRS follows acceptance by the peer-reviewers.The conference covered a comprehensive range of topics including speed, infrastructure and road design, cyclist safety, motorcyclist safety, pedestrian safety, road safety education, licensing, vehicle design, impairment due to distraction from mobile phones, alcohol, drugs as well as the impacts of climate change on future transport systems road safety, road safety issues for Indigenous people groups across New Zealand and Australia, integrating road safety into local Government, automated enforcement, gig economy road safety, older drivers, etc.

Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis).

Three seven-year-old African clawed frogs (Xenopus laevis) from an animal research facility showed weight loss, coelomic distention and an abnormal swimming gait were euthanised on welfare grounds. A complete necropsy of each animal showed a focal, firm, dark brown to green mass with multifocal haemorrhages in the left liver lobe in two animals and a transmural, firm, beige, multilobulated gastric mass in another animal. Additionally, one of the frogs with the hepatic mass had haemocoeloma. Histologically, the hepatic masses were diagnosed as hepatocellular adenomas and the gastric mass as a gastric carcinoma with trans-coelomic metastases. The three tumours were immunophenotyped using the following antibodies: cytokeratin AE1/AE3, vimentin, E-cadherin, P53 and Ki67 and, additionally, for the hepatic tumours only, synaptophysin, Prox-1, S100 and Sox-9. Masson's trichrome, Periodic acid Schiff and Gram stains was also performed in selected cases. One of the hepatocellular adenomas was weakly positively labelled with E-cadherin whereas the other showed variable positivity for Sox-9 only. Vimentin labelled the stroma and sinusoidal endothelia. Interestingly in the liver, the cytokeratin AE1/AE3 labelling was restricted to the biliary epithelium and sinusoidal endothelia. The gastric carcinoma labelled positively with cytokeratin AE1/AE3 only. This report aims to guide laboratory animal veterinarians to accurately diagnose multi-organ masses in amphibians. To the authors' knowledge, this is the first comprehensive morphological study on a case series of hepatocellular and gastric neoplasia in X. laevis.

AN AERODYNAMIC INVESTIGATION OF A HIGH-PRESSURE TURBINE USING ROTOR CASING STATIC PRESSURE MEASUREMENTS AT ENGINE REPRESENTATIVE CONDITIONS WITH DIFFERENT TIP DESIGNS, TIP GAPS AND INLET TEMPERATURE PROFILES

Abstract A rotating High-Pressure (HP) turbine, in modern aircraft engines, is subjected to high cyclic thermal and mechanical loads. Shroudless turbines experience high heat loads on the rotor tip and casing, which makes them one of the life-limiting components for an engine. If the rotor tip starts to erode, then the tip clearance increases which increases the over-tip leakage flow, resulting in reduced stage efficiency and ultimately, the engine lifetime. The Oxford Turbine Research Facility (OTRF) is a high- speed rotating transient test facility that allows unsteady aerodynamics and heat transfer measurements, at engine representative conditions. This paper presents an experimental investigation, of the HP turbine rotor casing aerodynamics, performed in the OTRF. Steady and unsteady casing static pressure measurements were acquired, using pneumatic lines and high-frequency response (∼ 100 kHz) Kulite pressure transducers respectively. The single-stage HP turbine consisted of cooled vanes (featuring film and trailing edge slot cooling), and uncooled rotor blades. Three different tip designs (two squealers and one flat) were tested, at two tip gaps, and with two inlet temperature profiles that included a spatially uniform total temperature profile and an engine representative HP turbine inlet total temperature profile. In parallel, a numerical investigation of the experimental test cases is presented using unsteady Computational Fluid Dynamics (CFD) predictions. The experimental results from this study provide a unique dataset to validate numerical models.

Near-infrared photoimmunotherapy in cancer treatment: a bibliometric and visual analysis

BackgroundNear-infrared photoimmunotherapy (NIR-PIT) is an emerging cancer treatment technology that combines the advantages of optical technology and immunotherapy to provide a highly effective, precise, and low side-effect treatment approach. The aim of this study is to visualize the scientific results and research trends of NIR-PIT based on bibliometric analysis methods.MethodsThe Web of Science Core Collection (WoSCC) database was searched in August 2024 for relevant publications in the field of NIR-PIT. Data were analyzed using mainly CiteSpace and R software for bibliometric and visual analysis of the country/region, authors, journals, references and keywords of the publications in the field.ResultsA total of 245 publications were retrieved, including articles (n = 173, 70.61%) and reviews (n = 72, 29.39%). The annual and cumulative number of publications increased every year. The highest number of publications was from the United States (149, 60.82%), followed by Japan (70, 28.57%) and China (33, 13.47%). The research institution with the highest number of publications was National Institutes of Health (NIH)-USA (114, 46.53%). Kobayashi H (109) was involved in the highest number of publications, Mitsunaga M (211) was the most frequently cited in total. CANCERS (17) was the most frequently published journal, and NAT MED (220) was the most frequently co-cited journal. The top 10 keywords include near-infrared photoimmunotherapy (166), photodynamic therapy (61), monoclonal antibody (58), in vivo (50), cancer (46), expression (31), breast cancer (27), enhanced permeability (24), antibody (23), growth factor receptor (16). Cluster analysis based on the co-occurrence of keywords resulted in 13 clusters, which identified the current research hotspots and future trends of NIR-PIT in cancer treatment.ConclusionThis study systematically investigated the research hotspots and development trends of NIR-PIT in cancer treatment through bibliometric and visual analysis. As an emerging strategy, the research on the application of NIR-PIT in cancer treatment has significantly increased in recent years, mainly focusing on the targeting, immune activation mechanism, and treatment efficacy in solid tumors has received extensive attention. Future studies may focus on improving the efficacy and safety of NIR-PIT in cancer treatment, as well as developing novel photosensitizers and combination therapeutic regimens, and exploring the efficacy of its application in a wide range of solid tumors, which will provide an important reference and guidance for the application of NIR-PIT in clinical translation.

Retracted] lncRNA TTN‑AS1 upregulates RUNX1 to enhance glioma progression via sponging miR‑27b‑3p.

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that the immunohistochemical images shown in Fig. 7E were strikingly similar to data that had already been published in different form in a previous article in the journal PLoS One written by different authors at different research institutes. Owing to the fact that the abovementioned data had already apparently been published previously, the Editor of Oncology Reports has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [Oncology Reports 44: 1064‑1074, 2020; DOI: 10.3892/or.2020.7684].

AI‐assisted research collaboration with open data for fair and effective response to call for proposals

AbstractBuilding teams and promoting collaboration are two very common business activities. An example of these are seen in the TeamingForFunding problem, where research institutions and researchers are interested to identify collaborative opportunities when applying to funding agencies in response to latter's calls for proposals. We describe a novel deployed system to recommend teams using a variety of Artificial Intelligence (AI) methods, such that (1) each team achieves the highest possible skill coverage that is demanded by the opportunity, and (2) the workload of distributing the opportunities is balanced among the candidate members. We address these questions by extracting skills latent in open data of proposal calls (demand) and researcher profiles (supply), normalizing them using taxonomies, and creating efficient algorithms that match demand to supply. We create teams to maximize goodness along a novel metric balancing short‐ and long‐term objectives. We evaluate our system in two diverse settings in US and India of researchers and proposal calls, at two different time instants about 1 year apart (total 4 settings), to establish generality of our approach, and deploy it at a major US university. We validate the effectiveness of our algorithms (1) quantitatively, by evaluating the recommended teams using a goodness score and find that more informed methods lead to recommendations of smaller number of teams and higher goodness, and (2) qualitatively, by conducting a large‐scale user study at a college‐wide level, and demonstrate that users overall found the tool very useful and relevant.

Beyond buzzwords: fostering interdisciplinary and collaborative global health research in Germany and beyond.

Germany has increased its political and financial commitment for global health, but this needs to be backed by a robust global health research ecosystem with strong partnerships in low- and middle-income countries (LMICs). This article suggests pathways for empowering researchers to operate beyond their disciplinary silos and strengthen partnerships across sectors and countries. The authors identify barriers and enablers of operations from a nascent research network in Germany, trusting that this experience can inform other initiatives seeking to stoke interdisciplinary and collaborative global health research. This article represents the culmination of extensive reflections spanning the initial four years of the German Alliance for Global Health Research (GLOHRA). The insights have additionally been informed by an analysis of publicly available reports, internal procedural records, and externally conducted studies based on interviews with researchers and policymakers. GLOHRA has developed a toolbox of practices that foster interdisciplinary research and support capacity-building. Insights indicate that highly interdisciplinary and diverse governance structures and seed-funding for interdisciplinary and cross-sector research with appropriate review processes represent a critical step for achieving these aims. Additionally, inclusive training sessions and networking events help to bridge disciplinary boundaries, equipping researchers to envision the broader context of their work. Despite achievements, challenges persist. Wider support, especially from universities and research institutions, is necessary to make global health research an attractive career path and to reduce bureaucratic barriers for collaborators in LMICs. Sustained, longer-term federal funding mechanisms will also be essential for ongoing progress.

Dynamic and Stable R&D Strategies for Green Technology Based on Cooperative Differential Games

As the “carbon neutrality” strategy is implemented, green technology R&D, a core competitive strength for sustainable enterprise development, is an essential pathway for China’s transformation and green growth. Green technology, a breakthrough over traditional production technologies, involves lengthy and costly R&D processes with high risks typically beyond the reach of a single enterprise. It requires the heterogeneous functions of enterprises, universities, and research institutions to complement each other’s advantages and establish an “industry–university–research” collaborative innovation alliance for green technologies. This paper constructs differential game models for non-cooperative and cooperative green technology R&D involving a green manufacturer and a research institution. We solve and compare the profits for both parties under these scenarios, apply a time-consistent payment distribution mechanism to allocate cooperative profits, and ensure that neither party deviates from the optimal cooperative trajectory over a prolonged period, achieving Pareto improvement and enhancing social welfare.

The Influence of Arrhythmia on the Outcomes of Pediatric Patients with Idiopathic Dilated Cardiomyopathy.

Children diagnosed with dilated cardiomyopathy (DCM) are at an increased risk of developing arrhythmias, which can significantly affect their overall prognosis. However, the implantation and effectiveness of implantable cardioverter-defibrillators (ICDs) pose challenges in the pediatric population. Therefore, it is crucial to determine the prevalence of arrhythmia-related death in pediatric patients with DCM. This study investigated the correlation between arrhythmias and mortality in pediatric patients with DCM. This retrospective cohort study examined children with idiopathic DCM referred to Rajaie Cardiovascular, Medical, and Research Institute in Tehran, Iran, from 2017 to 2023. All patients underwent a standard 12-lead electrocardiogram, 24-h Holter monitoring, cardiac magnetic resonance imaging, and echocardiography. Patient outcomes, including death, heart transplantation, and survival, were evaluated within one year of Holter monitoring. A total of 178 children (79 males) with a mean age of 83.06 ± 56.41months were included in the study. Overall, 72 deaths (40.4%) and 46 heart transplants (25.8%) were recorded and 60 patients (33.7%) survived. There was no significant association between patients' outcomes with ventricular arrhythmias, late gadolinium enhancement, corrected QT interval, and QRS interval prolongation; however, a significantly higher proportion of dead patients had abnormal heart rate variability (P = 0.034). Heart failure was the leading cause of death, with ventricular arrhythmia accounting for two out of 72 deaths. Both cases of ventricular arrhythmia were associated with severe cardiac dysfunction. Arrhythmia-related mortality is rare in children with idiopathic DCM, with severe heart failure being the primary cause of death in this population. Life-threatening arrhythmias primarily occur in DCM children with more compromised cardiac function.

Kutatások a szimbolikus térhasználat témakörében: áttekintés és szintézis

The study analyzes the symbolical space using practice in the period from the social-political turnaround of Romania in 1989 to the present in Szeklerland. The aim is to present the trended changes in the symbolical space using practice in the public space since the regime change. The study is based on results of research programs conducted at WAC – Centre for Regional and Anthropological Research. Analyzing the results of the research programs, we determined three intervals from 1990 to the present. In the first interval, symbolical space using practice was dominated by rehabilitation processes. In the second interval, creating new symbolic spaces and events was more typical. In the last interval, new processes have emerged, such as integration and individualization. In addition to analyzing the changes, we also aim at presenting the social function of symbolical space using practice in different time intervals.