To evaluate the clinical outcomes associated with the Biomedtrix Centerline canine cementless total hip arthroplasty implant (C-THA). 17 dogs (20 hips) surgically implanted with C-THA to treat coxofemoral pathology. Dogs with C-THA (2015 through 2020) with follow-up of ≥ 6 months were evaluated. Data included signalment, complications, management of complications, radiographs (bone implant interface), and clinical outcomes. Outcomes were assessed radiographically and subjectively via surgeon orthopedic examinations. 15 of 20 (75%) with long term radiographic follow-up had an excellent outcome. 5 hips (25%) had postoperative complications: femoral neck fracture (n = 1; 5%), aseptic loosening (2; 10%), and septic loosening (2; 10%). C-THA can restore function in dogs with coxofemoral pathology. This novel procedure showed outcomes comparable to initial reports of other traditional THA implants (cemented, cementless, and hybrid) but complications occurred at a higher rate than recent outcomes of other long-standing THA procedures. Increased case numbers and surgeon experience with this novel implant system may eventually yield results comparable to other accepted THA systems.