This article analyzes the effects of inclined angle (IA), filling times (FTs) and cement tailings ratio (CTR) on the uniaxial compressive strength (UCS) and crack development law of layered cemented backfill (LCB) using various research methods, including indoor experiments, numerical simulation, and computed tomography (CT) scanning. The research shows: (1) In the indoor experiments, it was observed that increasing the IA, increasing the number of FTs, and decreasing the CTR had a significant weakening effect on the UCS of the specimens. The greater the IA, the more pronounced the separation and dislocation of the layered contact surface, resulting in a significant increase in macroscopic cracks at the bottom. As the FTs increases, the center of gravity of the failure of the LCB gradually moves downwards. This causes the damage and failure time to advance, and the peak stress to change from one main crack to multiple main cracks. (2) During the numerical simulation, compressive stress accumulates and increases around the pores in the layered contact surface. Microcrack aggregation occurs on the contact surface, and downward expansion and extension. The peak strain energy decreases as the IA increases with the FTs. The number of shear cracks increased more at 20° to 30° than at 0° to 20°. The strain energy of the 0° specimen is the highest, while that of the 30° specimen is the lowest. (3) The CT scan shows that the LCB is affected by stress conduction hysteresis. When the bottom backfill is in the stage of crack evolution, the top backfill is in the stage of compaction.When the LCB reaches the peak stress, both the bottom and middle layers of the backfill lose load-bearing capacity, and the top layer of the backfill has no cracks. This paper provides reference value and research ideas for the destruction of backfill that contain layered defective structures.