Nanotechnology-based engineering approaches are rapidly developing throughout the world. Modern, cutting-edge nanotechnology has proven useful in a variety of technical applications. In emerging and developed countries, increasing infrastructure needs a considerable amount of cement, which has a significantly impact on the environment and human health, resulting in greenhouse gas emissions and severe acute respiratory illnesses (asthma and silicosis, respectively). To overcome such difficulties, cement consumption in building materials must be reduced. Several novel extra materials have lately been introduced to improve the performance of mortar. Nano-titanium dioxide (NT) in cement mortar is widely used in green building construction because NT capable to the degradation of air pollution, self-cleaning, and enhancing mechanical, microstructural, and durability properties. In this paper, the effect of NT on fresh and hardened properties of cement mortar has been discussed. For the collection, screening and implementation of data for review paper PRISMA analysis and VOSviewer technique was used. Existing literature indicates that the reduction in workability 15% − 20% whereas improvement in compressive strength (CS) up to 15% and tensile strength up to 45% was noted with NT in mortar. Current research supports using NT as a cement replacement in mortar. Aside from the key findings, some identified gaps, problems, and future scope challenges have been presented in order to develop NT based mortar as a sustainable material in the building sector.