Cellular Signaling Factors Research Articles

Effects of 1,25(OH) 2D 3 and vitamin D analogs on developmental control of cell growth and tissue-specific gene expression during osteoblast differentiation

Cultured normal diploid osteoblasts provide a model for identifying selective effects of vitamin D and 1,25(OH) 2D 3 analogs on expression of cell growth and tissue-specific genes that are dependent on the differentiated state of the bone cell. Transcription of the bone-specific osteocalcin gene is responsive to the vitamin D receptor complex together with other cellular signaling factors. Cultured normal diploid osteoblasts provide a model for identifying selective effects of vitamin D and 1,25-(OH) 2D 3 analogs on expression of cell growth and tissue-specific genes that are dependent on the differentiated state of the bone cell. Transcription of the bone-specific osteocalcin gene is responsive to the vitamin D receptor complex together with other cellular signaling factors.