Abstract Introduction: Based on the 2015 World Health Organization (WHO) Classification of Lung Tumors, we sought to investigate the relationship of common lung tumor histologies and their utility as prognostic clinical correlates of short-term perioperative outcomes. Methods: We retrospectively analyzed patients who underwent robotic-assisted video-thoracoscopic lobectomy by one surgeon over 81 months. Patients were grouped based on tumor histology on their final surgical pathology report. Patients' demographics, smoking history, lobar distribution, extent of resection, intraoperative outcomes, perioperative complications, and hospital length of stay were compared among the groups. Results: Among 420 study patients, the most common tumor type was adenocarcinoma (AD, 59.8%), followed by squamous cell carcinoma (SQ, 19.3%) and neuroendocrine carcinoma (NEC, 11.7%). Final histology for the remainder of the cohort consisted of adenosquamous carcinoma (AdSq, 2.1%) and pulmonary metastasis (7.1%). All patients with AdSq tumor histology had a positive smoking history, which was a significantly higher proportion than for those with NEC tumor type (100% vs 71.4%; p<0.001). Those with AdSq tumor histology were both significantly older and developed significantly larger tumors by time of resection (p<0.001 and p=0.003, respectively). Patients with AdSq tumors required more extensive resections compared to the remaining groups (p<0.004). They also experienced significantly greater estimated blood loss (EBL) and significantly longer operative times (p=0.005 and p=0.018, respectively) than the remaining groups. Patients with SQ or pulmonary metastasis had slightly more postoperative complications, but this was not statistically significant (p=0.990). Conclusion: Patients with AdSq histology type were older and had larger tumors, which put them at risk of intraoperative difficulties, with more extensive resections, longer operative times, and greater EBL. Despite this, AdSq histology did not affect the postoperative course. Citation Format: Roger Gerard, Frank Velez-Cubian, Carla Moodie, Joseph Garrett, Jacques Fontaine, Eric Toloza. Lung tumor histology as prognostic factor for short-term postoperative outcomes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 597.