Formation of long-lasting memory lymphocytes is one of the foundational characteristics of adaptive immunity and the basis of many vaccination strategies. Following the rapid expansion and contraction of effector CD8 T cells, the surviving antigen (A... Read More
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Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets
- Frontiers in Immunology
- VOL. 14
on Jan 23, 2023
- Memory CD8
- Function Of Memory CD8
- Number Of Memory CD8
- Independent Functions
- Sepsis-induced Changes
- Cell Subsets
- More +
Discussion of Annotated Research Articles Results in Increases in Scientific Literacy within a Cell Biology Course
- Journal of Microbiology & Biology Education
on Jan 23, 2023
- Cell Biology
- Cell Biology Course
- Literate Citizens
- Scientific Literacy
- Biology Course
- Research Articles
- More +
As the amount and complexity of scientific knowledge continues to grow, it is essential to educate scientifically literate citizens who can comprehend the process of science and the implications of technological advances. This is especially important... Read More
An assumption of the past climate and environment in millennial and centennial scale
- Journal of Environmental Biology
- VOL. 44
on Jan 23, 2023
- Mass Extinction
- Change In Climate
- Climatic Events
- Tertiary Mass Extinction
- Centennial Scale
- Permian-Triassic Mass Extinction
- More +
The approximate age of Planet Earth is around 4.54 billion years. This age of the earth has been determined from isotopic dating of the rock samples from the earth’s crust as well as from the soils and rocks of the moon and meteorites. Dating methods... Read More
Towards a structurally resolved human protein interaction network
- Nature Structural & Molecular Biology
on Jan 23, 2023
- Human Protein Interactions
- High-confidence Models
- Atomic Details
- Deep-learning Methods
- Molecular Machines
- Signaling Responses
- More +
Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their molecular mechanisms. However, fewer than 5% of hundreds of thousands of human protein inter... Read More
Ataxin‐1 controls the expression of specific non‐coding RNAs in B cells upon autoimmune demyelination
- Immunology & Cell Biology
on Jan 22, 2023
- SCA1
- Autoimmune Demyelination
- MS
- Professional Antigen Presenting Cells
- Protein Network Analyses
- MS Pathogenesis
- More +
B cells play a key mechanistic role in the pathogenesis of multiple sclerosis (MS), a chronic neurological disease of the central nervous system with an autoimmune etiology. B cells contribute to disease initiation and progression by acting as profes... Read More
A tribute to a man of science: lessons from Professor Luiz R. Travassos (1938–2020)
- Brazilian Journal of Microbiology
on Jan 20, 2023
- Cell Biologist
- Generations In Brazil
- Fields Of Microbiology
- Fields Of Biology
- Aspects Of Life
- Cancer Biology
- More +
Luiz Rodolpho Raja Gabaglia Travassos, MD, PhD was a world-class microbiologist and cell biologist whose contributions to science were remarkable at multiple levels and across diverse fields. Besides being responsible for the creation of a scientific... Read More
Targeting Mitochondria to Control Ageing and Senescence
- Pharmaceutics
- VOL. 15
on Jan 20, 2023
- Biology In Cells
- Alterations In Mitochondrial Functions
- Cellular Senescence
- Senescent Cells
- Hallmarks Of Ageing
- Deterioration Of Organs
- More +
Ageing is accompanied by a progressive impairment of cellular function and a systemic deterioration of tissues and organs, resulting in increased vulnerability to multiple diseases. Here, we review the interplay between two hallmarks of ageing, namel... Read More
CaMKII as a Therapeutic Target in Cardiovascular Disease
- Annual Review of Pharmacology and Toxicology
- VOL. 63
on Jan 20, 2023
- CaMKII
- CaMKII Inhibitors
- Multifunctional Ca2
- Pathological Signaling
- Therapeutic Inhibition
- Splice Variants
- More +
CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly validated signal for promoting a variety of common diseases, particularly in the cardiovascular system. Despite substantial amounts of convincing preclinical da... Read More
ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning
- Science Advances
- VOL. 9
on Jan 20, 2023
- Cellular Biology
- Branch Junction
- Subunit Isoforms
- Actin Network
- Phosphoprotein Family
- Cell Migration
- More +
Regulation of the Arp2/3 complex is required for productive nucleation of branched actin networks. An emerging aspect of regulation is the incorporation of subunit isoforms into the Arp2/3 complex. Specifically, both ArpC5 subunit isoforms, ArpC5 and... Read More
A guide to UFMylation , an emerging posttranslational modification
- The FEBS Journal
on Jan 20, 2023
- UFM1
- UFMylation Pathway
- ER
- Neurodevelopmental Diseases
- Ubiquitin-like Modifier
- Telomere Maintenance
- More +
Ubiquitin Fold Modifier-1 (UFM1) is a ubiquitin-like modifier (UBL) that is posttranslationally attached to lysine residues on substrates via a dedicated system of enzymes conserved in most eukaryotes. Despite the structural similarity between UFM1 a... Read More
T cell functions and organ infiltration by leukemic T cells require cortactin
- Journal of Leukocyte Biology
on Jan 19, 2023
- Actin Polymerization In Response
- Organ Infiltration
- Relapse In B-ALL
- Role Of Cortactin
- Immune Synapse Formation
- Aggressive Hematological Malignancy
- More +
Abstract T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that is still fatal in many cases. T cell blasts are characterized by hyperactivation and strong proliferative and migratory capacities. The... Read More
Quantum tunneling time delay investigation of $${{\varvec{K}}}^{+}$$ ion in human telomeric G-quadruplex systems
- JBIC Journal of Biological Inorganic Chemistry
on Jan 19, 2023
- Charge Accumulation Rate
- Entropic Time
- Time Delay
- Picoampere Range
- Potential Energy Barrier
- Human Telomere
- More +
Guanine-rich quadruplex DNA (G-quadruplex) is of interest both in cell biology and nanotechnology. Its biological functions necessitate a G-quadruplex to be stabilized against escape of the monovalent metal cations. The potassium ion ([Formula: see t... Read More
The role of innate immune cells in the tumor microenvironment and research progress in anti-tumor therapy
- Frontiers in Immunology
- VOL. 13
on Jan 19, 2023
- Role Of Innate Immune Cells
- Bone Marrow Derived Suppressor Cells
- Innate Immune Cells
- Pro-tumor Role
- TME
- Cells In Tumorigenesis
- More +
Innate immune cells in the tumor microenvironment (TME) mainly include macrophages, neutrophils, natural killer cells, dendritic cells and bone marrow derived suppressor cells. They play an anti-tumor or pro-tumor role by secreting various cytokines,... Read More
A role of biomaterials in tissue engineering and drug encapsulation
- Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
on Jan 19, 2023
- Mechanical Qualities
- Medicine Delivery Systems
- Biomaterials In Tissue Engineering
- Medical Technology Development
- Common Biomaterials
- Tissue Engineering
- More +
The paper provides an introduction to biomaterials covered and their available types, such as metal, ceramic, polymer, and composites. Biomaterials are structures, devices, or materials that may repair or implant tissue. Biomaterials are biocompatib... Read More
Investigation on acquired palbociclib resistance by LC-MS based multi-omics analysis
- Frontiers in Molecular Biosciences
- VOL. 10
on Jan 19, 2023
- Palbociclib Resistance
- Palbociclib Resistant Cells
- Multi-omics Analysis
- Multiple Types Of Tumors
- Regulation Of Chemotaxis
- N-glycosylation Inhibitors
- More +
Palbociclib is a specific CDK4/6 inhibitor that has been widely applied in multiple types of tumors. Different from cytotoxic drugs, the anticancer mechanism of palbociclib mainly depends on cell cycle inhibition. Therefore, the resistance mechanism ... Read More
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing
- EMBO Molecular Medicine
on Jan 18, 2023
- Biology In Cells
- Deep Intronic Variant
- Recessive Osteogenesis Imperfecta
- Extracellular Matrix Biology
- Disease-relevant Cells
- OI
- More +
Exome sequencing has introduced a paradigm shift for the identification of germline variations responsible for Mendelian diseases. However, non-coding regions, which make up 98% of the genome, cannot be captured. The lack of functional annotation for... Read More
Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
- eLife
- VOL. 12
on Jan 17, 2023
- Merkel Cells
- Merkel Cell
- Somatosensory Axons
- Dermal Appendage
- Zebrafish Epidermis
- Touch System
- More +
Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex. Development and patterning of Merkel cells and associated neurite... Read More
Correlative Multi-Modal Microscopy: A Novel Pipeline for Optimizing Fluorescence Microscopy Resolutions in Biological Applications
- Cells
- VOL. 12
on Jan 17, 2023
- Correlative Microscopy
- Maximum Spatial Resolution
- Spatial Resolution
- Super Resolution Microscopy
- Statistical Sampling
- Fusion Of Technologies
- More +
The modern fluorescence microscope is the convergence point of technologies with different performances in terms of statistical sampling, number of simultaneously analyzed signals, and spatial resolution. However, the best results are usually obtaine... Read More
Novel STAT3 inhibitor exerts anti-breast cancer effects both in vitro and in vivo
- Letters in Drug Design & Discovery
- VOL. 20
on Jan 16, 2023
- Potential In Breast Cancer Cells
- STAT3
- Migration Of Cells
- Breast Cancer Cells
- Decrease Of Mitochondrial Membrane Potential
- Migration Of Breast Cancer Cells
- More +
Background: Breast cancer is one of the most common malignant tumors. Signal transduction and activators of transcription 3 (STAT3) have been demonstrated to play important roles in breast cancer. However, no direct inhibitor of STAT3 has been appro... Read More
Emerging concepts in oligodendrocyte and myelin formation, inputs from the zebrafish model
- Glia
on Jan 16, 2023
- Myelin Formation
- CNS Myelination
- OL Precursor Cells
- Myelin Sheath Formation
- Axo-glial Interactions
- CNS
- More +
Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS), which are derived from OL precursor cells. Myelin insulates axons allowing the saltatory conduction of action potentials and also provides trophic and metabolic sup... Read More