Objectives: The benefits of topical drug delivery systems, which have been used for centuries, include the ability to deliver medications both quickly to the affected area where they are most effective and over an extended period of time. These systems lengthen the drug's mean resident time and contact time. The design and characterization of an antibiotic emulgel for topical medication administration is a goal of the current investigation. Methods: Cefpodoxime Proxetil emulgel were prepared using different concentration of Carbopol 934, HPMC K4M and xanthan gum as gelling agents and evaluated the relevant parameters such as physical examinations, pH, extrudability, spreadability, viscosity, swelling index, drug content, in-vitro diffusion studies and microbiology activities. Results: All formulations are neutral and viscosity of emulgel was found in the acceptable limits. On physical evaluations were found to be optimum in terms spreadability, swelling index and extrudability. Drug content of all formulations were found in the ranges 69.73% to 97.58% and CEF4 emulgel exhibiting the highest drug concentration and the lowest percentage drug release due to its controlled release pattern and proven non-fickian diffusion mechanism release. The results found that, the selected formulations proven better bacterial activities against both gram positive and gram negative organisms. Conclusions: Type and concentration of polymers can have an impact on the drug permeability studies and physical-chemical characteristics of the developed antibiotic emulgel, which had excellent results and was suitable for possible therapeutic purposes.