CD30-positive Large Cell Transformation Research Articles

249 Differences of spatially resolved transcriptome profile between mycosis fungoides with CD30-positive large cell transformation and primary cutaneous anaplastic large cell lymphoma

249 Differences of spatially resolved transcriptome profile between mycosis fungoides with CD30-positive large cell transformation and primary cutaneous anaplastic large cell lymphoma

Indolent CD30-Positive Extranodal NK/T Cell Lymphoma with Large Cell Transformation: Case Report and Literature Review.

The nasal type of extranodal natural killer (NK)/T-cell lymphoma (ENKL) is an aggressive form of non-Hodgkin's lymphoma. Although ENKL is most commonly seen in the midline of the nose, face and Waldeyer's ring, it can also occur in the skin, gastrointestinal tract, soft tissues and other parts of the body. Severe ENKL cases are accompanied by hemophagocytosis, with clinical manifestations such as high fever, hepatosplenomegaly, and decreased blood cell count. ENKL at different locations exhibits similar histological features and immunophenotypes, such as a strong affinity for T cell markers CD2 and CD56, cytotoxic molecules, as well as a strong positive for EBER after in situ hybridization. Although indolent ENKL is extremely rare, we hereby present a case study of primary NK/T cell lymphoma in the spinal canal with the initial manifestation of a diffuse growth of small cells, and the survival and recurrence details after 11years, accompanied by CD30-positive large cell transformation. The patient's condition after treatment has improved and is currently in good health.

The importance of differentiating between mycosis fungoides with CD30-positive large cell transformation and mycosis fungoides with coexistent primary cutaneous anaplastic large cell lymphoma

The importance of differentiating between mycosis fungoides with CD30-positive large cell transformation and mycosis fungoides with coexistent primary cutaneous anaplastic large cell lymphoma

Inert natural killer/T-cell lymphoma with large cell transformation: report of one case and review of literature

Objective To investigate the clinicopathologic features of inert natural killer/T (NK/T)-cell lymphoma with CD30-positive large cell transformation. Methods The pathological data of one patient diagnosed as inert NK/T-cell lymphoma with CD30-positive large cell transformation in the Third Hospital Affiliated to Soochow University from April 2006 to March 2017 were collected. The histopathological features and immunohistochemical phenotype of the patient were observed and followed up. Results The patient received biopsy twice in April 2006 and March 2017. The first tumorectomy in sacral canal showed that diffuse and small lymphoid cell hyperplasia, irregular nucleus, granular chromatin, unobvious nucleolus, focal necrosis. Immunohistochemistry showed CD20(-), CD3(-), ALK(-), CD30(-), CD43(+), CD2(+), CD56(+), TIA-1(+), GrB(+), CD4(-), CD8(-). Finally, the patient was diagnosed as extranodal NK/T-cell lymphoma, nasal type. The microscopic examinations after the second left cervical lymph node biopsy showed large cells infiltrated into the background of small lymphocytes, plentiful cytoplasm, large nuclei, irregular nucleus, part of nuclear folding, obvious nucleolus, mitotic figures visible, visible intravascular tumor suppository, consistent small lymphocytes. Blood vessel invasion could be seen, as wells as consistent small lymphocytes, regular form, less cytoplasm, rare nuclear fission. Immunohistochemistry showed AE1/AE3(-), CD20(-), CD3(+), ALK(-), CD30(+), CD43(+), CD2(+), EMA(-), Ki-67(70%+), CD56(+), TIA-1(+), GrB(+), CD4(-), CD8(-). Finally, the patient was diagnosed as NK/T-cell lymphoma, nasal, recurrence. In situ hybridization showed EB virus encoded RNA (EBER) was positive for two biopsies. Conclusions Inert extranodal NK/T-cell lymphoma is very rare. The pathogenesis is closely related to EB virus infection. Its diagnosis must rely on histopathology and immunohistochemistry. Key words: Natural killer/T-cell lymphoma, nasal type; Inert; Epstein-Barr virus

Alitretinoin treatment in mycosis fungoides with CD30-positive large cell transformation

Alitretinoin treatment in mycosis fungoides with CD30-positive large cell transformation

Early stage mycosis fungoides with focal CD30-positive large cell transformation

Mycosis fungoides (MF) is typically an indolent disease except when large cell transformation (LCT) occurs. The incidence of LCT has been reported to range from 6% to 23% under the criterion of the presence of more than 25% of large cells in a biopsy of typical MF lesions. LCT is more common in advanced-stage MF, but very rarely found in its early stage. Herein, we present a 45-year-old woman with patch stage MF (Stage IB) who developed a papule within one patch, which revealed large cell transformation with expression of CD30 immunostaining on histopathology. The patient then received phototherapy with narrow-band UVB. The skin lesions regressed quickly and no new skin lesions had been noted during the 6-month follow-up. Intense monitoring for recurrence and extracutaneous involvement is still recommended. In this article, we also review the published articles of mycosis fungoides with CD 30-positive large cell transformation and analyze the clinicopathological and prognostic features.

Large cell transformation mimicking regional lymphomatoid papulosis in a patient with mycosis fungoides

A 57-year-old Japanese man with tumor-stage mycosis fungoides suddenly presented multiple small papules on the right chest. Histopathology of a biopsy specimen from the papules revealed medium-to-large pleomorphic lymphoid cells throughout the entire dermis but not in the epidermis, and the large cells expressed CD30 antigen. These newly-developed papules underwent spontaneous remission in the following 3 months. We reviewed the reported cases of mycosis fungoides, which showed CD30-positive large cell transformation and those of CD30-positive lymphoproliferative disorders associated with mycosis fungoides.