Abstract. Hidayati I, Wiryanto, Setyawan AD. 2011. Cadmium content in thothok shellfish (Geloina erosa) from mangrove area of Segara Anakan Cilacap, Central Java. Bonorowo Wetlands 1: 51-57. The aim of this study was to determine the Cd metal content in meat of thothok shellfish (Geloina erosa), water, and sediments in the mangrove area of Segara Anakan, Cilacap, Central Java i.e., Muara Dua, Motean, and Lomanis. The study was conducted in June-November 2005 with two replication samples. Seawater and sediment samples were taken at a depth of 3 meters from the water surface, while shellfish were taken at random. Cd level was analyzed using AAS (Atomic Absorption Spectrophotometer). Other parameters measured are environmental parameters (i.e. temperature and pH). The results showed that the average measurement in three stations was: Cd content in shellfish meat 0.05 mg/kg (ppm), seawater 0.04 mg/kg, and sediment 0.12 mg/kg, temperature 30.8 C, and pH value 7.66. The highest levels of Cd are found in sediments. ANOVA statistical analysis showed that the metal content of Cd in the three stations tends to be uniform. Cd content in shellfish and temperature showed a direct correlation of +0.193. Cd content in water and sediment with temperature had a reverse correlation of -0.038 and -0.174. Cd content in shellfish and water with pH showed an inverse correlation of -0.070 and -0.125. Cd content in sediment with pH had a significant direct correlation of +0,699.