Event Abstract Back to Event Role of the endocannabinoid system in the control of bony fish feeding response Maria F. Franzoni1*, A. Guastalla1, V. Pomatto1, E. Cottone1 and E. Campantico1 1 Universita degli Studi di Torino, Dipartimento di Biologia Animale e dell'Uomo, Lab, Italy CB1 cannabinoid receptors are the most abundant G-protein-coupled receptors in the mammalian brain. The characterization of two CB1 genes in the brain of the bonyfish Fugu rubripes aroused the interest for the comparative neurobiology and phylogenetic aspects of the endocannabinoids and their receptors. Among the multiple functions modulated by the cannabinoids through the CB1 receptors, the control of the feeding response is perhaps the one that has been investigated the most in several phyla. In mammals, it was reported that endocannabinoids behave as orexigenic mediators and indeed CB1 antagonists have been developed for the obesity treatment. Furthermore, it was demonstrated that food deprivation induces the release of endocannabinoids. In the last few years, we have studied the endocannabinoid system in different species of bonyfish and its possible role in the feeding response. Interestingly, we found that CB1 receptors are abundant in bonyfish forebrain regions involved in the control of food-intake. In the goldfish, food deprivation induces a significant increase of both the endocannabinoid anandamide (AEA) and CB1 mRNA levels that lower after refeeding. AEA causes a dose-dependent effect on food intake and affects CB1 mRNA expression, as well as that of NPY. Moreover, we found a topographical codistribution of the CB1 receptors with NPY and CRF, which are involved in the control of the feeding response. In conclusion, our results support the role of the endocannabinoid system in the control of energy intake also in lower vertebrates, by possibly interplaying with other orexigenic/anorexigenic factors Conference: 3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009. Presentation Type: Oral Presentation Topic: Symposium 12 – Comparative Neuroendocrinology: novel neurochemical systems Citation: Franzoni MF, Guastalla A, Pomatto V, Cottone E and Campantico E (2009). Role of the endocannabinoid system in the control of bony fish feeding response. Front. Neurosci. Conference Abstract: 3rd Mediterranean Conference of Neuroscience . doi: 10.3389/conf.neuro.01.2009.16.046 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Nov 2009; Published Online: 19 Nov 2009. * Correspondence: Maria F Franzoni, Universita degli Studi di Torino, Dipartimento di Biologia Animale e dell'Uomo, Lab, Torino, Italy, mariafosca.franzoni@unito.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Maria F Franzoni A. Guastalla V. Pomatto E. Cottone E. Campantico Google Maria F Franzoni A. Guastalla V. Pomatto E. Cottone E. Campantico Google Scholar Maria F Franzoni A. Guastalla V. Pomatto E. Cottone E. Campantico PubMed Maria F Franzoni A. Guastalla V. Pomatto E. Cottone E. Campantico Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.