This in vitro study compared the marginal adaptation of CAD/CAM and laboratory-made ceramic inlays before, during and after loading. Six MOD inlay preparations of standardized design with one cervical margin in dentine and the other in enamel were prepared for each inlay type: CAD/CAM fabricated MGC-glass ceramic inlays, CAD/CAM fabricated feldspathic porcelain inlays, laboratory-made glass ceramic inlays and laboratory-made feldspathic porcelain inlays. Appropriate luting composite materials were used. The restored teeth were subjected to occlusal loading, thermal cycling, toothbrush-toothpaste abrasion and chemical degradation in vitro. Marginal adaptation was quantitated along the entire length of the cavosurface margin and along selected sections of the margin using SEM, following in vitro testing corresponding to 0, 0.5, 1.0, 2.7 and 5.0 years of clinical service. In addition, marginal fit of the cemented inlays was evaluated in the SEM. The initial marginal adaptation in enamel was excellent in all groups. After in vitro testing, significant marginal discrepancies were found in all groups. A high percentage of marginal openings was recorded, notably in the cervical portions of the margins in both enamel and dentine.
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