My justification for reporting a single example of chondro-osteodystrophy or Morquio's disease is that the case presents so many features of unusual interest. I was unable to find in the literature any instance in which the patient was observed during the period of pregnancy, with delivery by cesarean section. Whereas other cases have been described in children and young adults, this patient was 26 years old. The case is, I believe, the second to be reported in a Negro. Case Report L. C. (No. 115-059), a colored female dwarf, was admitted to the University Hospitals on March 9, 1942, because of severe dyspnea, which was attributed to her pregnancy. She stated that her last menstrual period had been in August 1941, and that previous to that date the menses had been regular and normal, beginning at the age of fourteen. She had never been able to walk without some support. Both parents were dead; a sixteen-year-old brother was healthy and normal. Her step-father was responsible for her pregnancy. The patient's body length was 36 inches and her weight 58 pounds. The head was larger than even a normal head, with eyes set far apart and the bridge of the nose depressed. The neck was not discernible and the massive lower jaw rested on the upper part of the chest. The breasts were normally developed and engorged. The abdomen was distended and an umbilical hernia was present. The fundus of the uterus seemed to occupy most of the abdominal cavity and fetal heart tones could be heard in the left lower quadrant at a rate of 140/min. All the extremities were short and stubby; the joints were enlarged and excessively flexible. The external genitalia were normally developed. Although hearing was somewhat impaired the patient answered questions fairly intelligently and could read and write. Both the Wassermann and Kahn reactions were strongly positive. The red cell count was 3,200,000; white count 9,800; serum calcium 7.3; phosphorus 5.96. The pelvic measurements were as follows: spines 15 cm.; crests 18 cm.; trochanter 22 cm.; external conjugate 12 cm. The x-ray findings were characteristic, in every respect, of Morquio's disease. They were as follows: Head: The posterior clinoid process appeared thick and blunted, and the mandible massive. Spine: The cervical portion of the spine was shortened and distorted; the thoracic curve was kyphotic, whereas the lumbar curve was lordotic All the vertebral bodies were flattened and tongue-shaped, and had an irregular outline. The intervertebral spaces were widened. The sacral vertebrae were not fused and the coccyx could not be identified. There was a spina bifida of the fifth lumbar and first sacral vertebrae. Pelvis: There was a failure of fusion of the symphysis and the conjoined portion of the pubic and ischial rami. The acetabula were shallow, widened, and irregular in outline. The Y-shaped piece of cartilage of the acetabulum persisted. The femoral heads could not be identified.