Cavity Regime Research Articles

The Balance Between Shear Flow and Extracellular Matrix in Ovarian Cancer-on-Chip.

Ovarian cancer is the most lethal gynecologic cancer in developed countries. In the tumor microenvironment, the extracellular matrix (ECM) and flow shear stress are key players in directing ovarian cancer cells invasion. Artificial ECM models based only on ECM proteins are used to build an ovarian tumor-on-chip to decipher the crosstalk between ECM and shear stress on the migratory behavior and cellular heterogeneity of ovarian tumor cells. This work shows that in the shear stress regime of the peritoneal cavity, the ECM plays a major role in driving individual or collective ovarian tumor cells migration. In the presence of basement membrane proteins, migration is more collective than on type I collagen regardless of shear stress. With increasing shear stress, individual cell migration is enhanced; while, no significant impact on collective migration is measured. This highlights the central position that ECM and flow shear stress should hold in in vitro ovarian cancer models to deepen understanding of cellular responses and improve development of ovarian cancer therapeutic platforms. In this frame, adding flow provides significant improvement in biological relevance over the authors' previous work. Further steps for enhanced clinical relevance require not only multiple cell lines but also patient-derived cells and sera.

Analysis of spin-squeezing generation in cavity-coupled atomic ensembles with continuous measurements

We analyze the generation of spin-squeezed states via coupling of three-level atoms to an optical cavity and continuous quantum measurement of the transmitted cavity field in order to monitor the evolution of the atomic ensemble. Using analytical treatment and microscopic simulations of the dynamics, we show that one can achieve significant spin squeezing, favorably scaling with the number of atoms N. However, contrary to some previous literature, we clarify that it is not possible to obtain Heisenberg scaling without the continuous feedback that is proposed in optimal approaches. In fact, in the adiabatic cavity removal approximation and large N limit, we find the scaling behavior N−2/3 for spin squeezing and N−1/3 for the corresponding protocol duration. These results can be obtained only by considering the curvature of the Bloch sphere, since linearizing the collective spin operators tangentially to its equator yields inaccurate predictions. With full simulations, we characterize how spin-squeezing generation depends on the system parameters and departs from the bad cavity regime, by gradually mixing with cavity-filling dynamics until metrological advantage is lost. Finally, we discuss the relevance of this spin-squeezing protocol to state-of-the-art optical clocks.

Ocean cavity regime shift reversed West Antarctic grounding line retreat in the late Holocene

Recent geologic and modeled evidence suggests that the grounding line of the Siple Coast of the West Antarctic Ice Sheet (WAIS) retreated hundreds of kilometers beyond its present position in the middle to late Holocene and readvanced within the past 1.7 ka. This grounding line reversal has been attributed to both changing rates of isostatic rebound and regional climate change. Here, we test these two hypotheses using a proxy-informed ensemble of ice sheet model simulations with varying ocean thermal forcing, global glacioisostatic adjustment (GIA) model simulations, and coupled ice sheet-GIA simulations that consider the interactions between these processes. Our results indicate that a warm to cold ocean cavity regime shift is the most likely cause of this grounding line reversal, but that GIA influences the rate of ice sheet response to oceanic changes. This implies that the grounding line here is sensitive to future changes in sub-ice shelf ocean circulation.

Quantum resonant optical bistability with a narrow atomic transition: bistability phase diagram in the bad cavity regime

We report on the observation of a novel manifestation of saturation-induced optical bistability in a resonantly pumped optical ring cavity interacting strongly with a cloud of atoms via a narrow atomic transition. The bistability emerges, above a critical pump rate, as an additional peak in the cavity’s normal mode spectrum close to atomic resonance. This third transmission peak is usually suppressed due to strong resonant absorption, but in our experiment it is visible because of the linewidth of the atomic transition being much smaller than that of the cavity, which sets the experiment into the bad-cavity regime. Relying on complete saturation of the transition, this bistability has a quantum origin and cannot be mimicked by a classical material presenting a nonlinear refraction index. The appearance of the central peak in addition to the normal modes is predicted by a semi-classical model derived from the Tavis–Cummings Hamiltonian from which we derive a bistability phase diagram that connects our observations with former work on optical bistability in the good cavity regime. The phase diagram reveals several so far unexplored bistable phases.

Qubit-Photon Bound States: Crossover from Waveguide to Cavity Regime

Qubit-Photon Bound States: Crossover from Waveguide to Cavity Regime

Mechanical cooling in the bistable regime of a dissipative optomechanical cavity with a Kerr medium

Mechanical cooling in the bistable regime of a dissipative optomechanical cavity with a Kerr medium

Optomechanical Simulation of a Parametric Oscillator

We study an optomechanical device supporting at least three optical modes in the infrared telecommunication band and three mechanical vibration modes. We model the coherent driving of each optical mode, independently of each other, to obtain an effective Hamiltonian showing the different types of parametric processes allowed in the device. We propose a bichromatic driving scheme, in the lossy optical cavity regime, under a mean field approximation, that provides the quantum simulation of a parametric oscillator with optical control of its parameters.

Machine learning-assisted extreme events forecasting in Kerr ring resonators

Predicting complex nonlinear dynamical systems has been even more urgent because of the emergence of extreme events such as earthquakes, volcanic eruptions, extreme weather events (lightning, hurricanes/cyclones, blizzards, tornadoes), and giant oceanic rogue waves, to mention a few. The recent milestones in the machine learning framework o↵er a new prospect in this area. For a high dimensional chaotic system, increasing the system’s size causes an augmentation of the complexity and, finally, the size of the artificial neural network. Here, we propose a new supervised machine learning strategy to locally forecast bursts occurring in the turbulent regime of a fiber ring cavity.

Experimental investigation of wall-pressure fluctuations in compressible turbulent cavitating flows with emphasis on non-Gaussian features

An accurate probabilistic representation of pressure fluctuations in attached turbulent cavitating flows, especially under strong unsteady cavity regimes, i.e., cloud cavitation, is essential for the reliable prediction of cavitation loads and thus preventing potential cavitation damage. The objective of this work is to examine the wall pressure fluctuations in compressible turbulent cavitating flows, especially the non-Gaussian behaviors and their physical mechanisms. Experiments were conducted in the backward-facing wedge model installed in a high-speed water tunnel. Four high-frequency PCB pressure transducers were installed on the divergent section to capture the cavitation-induced pressure fluctuation signals. The results showed that wall-pressure fluctuations in cavitating flows present non-Gaussian features with positive skewness, and this positive skewness is independent of the cavity regime, which is an intrinsic nature of cavitating flows. However, the fluctuating pressure signals under different cavity regimes show differences. At inception and in the sheet cavity, high-frequency and low-magnitude fluctuating pressure signals are responsible for the positive skewness. At the cloud cavitation cavity, both high-frequency and low magnitude and low-frequency and high-magnitude fluctuating pressure signals are responsible for the positive skewness. In particular, when shockwave dynamics are dominant, a unique kind of fluctuating pressure signal with high frequency and large magnitude is found to be the cause. Finally, the Hilbert-Huang transform (HHT) is employed to analyze the fluctuating pressure signals in cloud cavitation, and a physical model based on cavitation bubble dynamics is proposed. The current study can help to improve the understanding of the dynamics and pressure loads of cavitation.

Squeezing Light via Levitated Cavity Optomechanics

Squeezing light is a critical resource in both fundamental physics and precision measurement. Squeezing light has been generated through optical-parametric amplification inside an optical resonator. However, preparing the squeezing light in an optomechanical system is still a challenge for the thermal noise inevitably coupled to the system. We consider an optically levitated nano-particle in a bichromatic cavity, in which two cavity modes could be excited by the scattering photons of the dual tweezers, respectively. Based on the coherent scattering mechanism, the ultra-strong coupling between the cavity field and the torsional motion of nano-particle could be achieved for the current experimental conditions. With the back-action of the optically levitated nano-particle, the broad single-mode squeezing light can be realized in the bad cavity regime. Even at room temperature, the single-mode light can be squeezed for more than 17 dB, which is far beyond the 3 dB limit. The two-mode squeezing light can also be generated, if the optical tweezers contain two frequencies, one is on the red sideband of the cavity mode, the other is on the blue sideband. The two-mode squeezing can be maximized near the boundary of the system stable regime and is sensitive to both the cavity decay rate and the power of the optical tweezers.

Topology and cavitation number characteristics of the gaseous jet-induced tail cavity under co-flow

The tail cavity as induced by submerged gaseous jets on the bottom of axisymmetric vehicles is studied in a water tunnel over Froude numbers, which denote co-flow velocities, between 4.8 < Fr < 16.0, and the jet stagnation to ambient pressure ratio in a convergent–divergent nozzle between 1.7 < p0/p∞ < 14.5. The shadowgraph topology of the induced tail cavity falls into three consecutive categories on the regime map: intact cavity, partially broken cavity (PBC), and pulsating foamy cavity. Both the Fr and p0/p∞ are essential drivers for the topology and length of the tail cavity within the current scope. The length of PBC holds a logarithmic relationship to p0/p∞. The fluctuation intensity of the cavitation number is under heavy influence from Fr and p0/p∞ and is regarded as a direct and reliable measurement of jet/closure interaction intensity. Under high Fr, the Rayleigh–Taylor instability is dominant at the cavity surface, which leads to a significant amount of bubble shedding and adds to the total cavity gas leakage. From the perspective of the vehicle, the characteristics of its bottom pressure depend on the cavity regime. The characteristics of jet-induced tail cavity established in the presented study should be helpful for the design and control of submarine vehicles propelled by rockets and supersonic jets.

Predição da vazão perdida por jatos de água ascendentes aflorantes no solo

Abstract This paper presents experimental studies to explore the behavior of upward water jets in granular beds. The test conditions included both the cavity and chimney regime. Combining our results with data available in the literature, it was possible to fit a linear relationship to describe the dimensionless upward water velocity at the bed surface (u/U) as a function of kFr, in which Fr is the Froude number and k is a fitting parameter that was linearly related with the medium particle diameter d. A threshold condition (kFr = 1) was also proposed to predict the onset of the chimney regime, which was consistent with published data. Finally, a simple equation based on d, D and H was derived to predict the real-scale leakage flow rate Q from upward water jets bursting at the ground. The results obtained will potentially help water utilities estimate the water loss from underground pipelines.

Cavity-immune spectral features in the pulsed superradiant crossover regime

Lasing in the bad cavity regime has promising applications in precision metrology due to the reduced sensitivity to cavity noise. Here we investigate the spectral properties and phase behavior of pulsed lasing on the $^1$S$_0 - ^3$P$_1$ line of $^{88}$Sr in a mK thermal ensemble, as first described in arxiv:1903.12593. The system operates in a regime where the Doppler-broadened atomic transition linewidth is several times larger than the cavity linewidth. We find that by detuning the cavity resonance, the influence of the cavity noise on the peak lasing frequency can be eliminated to first order despite the system not being deep in the bad cavity regime. Experimental results are compared to a model based on a Tavis-Cummings Hamiltonian, which enables us to investigate the interplay between different thermal velocity classes as the underlying mechanism for the reduction in cavity noise. These velocity-dependent dynamics can occur in pulsed lasing and during the turn-on behavior of lasers in the superradiant crossover regime.

Destabilization of Immersed Dense Granular Material Submitted to Localized Fluidization: An Experimental and Numerical Study

An alternative experimental approach and a numerical analysis for the study of destabilization by localized fluidization of an immersed dense granular material are presented. To visualize the evolutions of the internal structure of the granular medium, the hydrogel beads, composed of about 99% of water and having substantially the same refraction indexes, are used as solid phase. A LED lighting system is used in place of a laser lighting system. As a result, the optical access restriction of porous structure is removed. A real economic alternative for the experimental study of fluid-grain coupling during destabilization by localized fluidization of a granular material is created. The experimental phenomenology presented in the literature is verified: the system passes successively through three different stationary regimes: static regime, fluidized cavity regime, and fluidized chimney regime. Some restrictions of using hydrogel beads as particles in the study of liquid-solid interaction are also discussed.

Experimental and numerical investigation on the cavity regime and drag reduction of ventilated partial cavity

This study presents the experimental and numerical investigation on the ventilated partial cavity (VPC) under the influence of the 3-D flow effect (i.e. the flow non-uniformity induced by the lateral space). The VPC is generated from the backward-facing step of a flat plate in water tunnel. The computational fluid dynamics together with the VOF method is applied to simulate the cavity flow. Four cavity regimes are clarified, referred to as two-branch cavity (TBC), single-tail cavity (STC), intermittent fully covered cavity (IFCC), and fully covered cavity (FCC). The cavity length of TBC in current experiments is much smaller than that observed in experiments of 2D wall-mounted cavitators. This contradictory observation is attributed to the stream-wise vortexes induced by the 3-D flow effects. The stream-wise vortexes induce local low-pressure cores and make cavity branches easier to extend downstream. The cavity length and drag reduction of VPC are both found to first increase linearly and then plateaus with ventilation rate. For TBC and STC, the drag reduction is only determined by the cavity coverage. For FCC and IFCC, no clear relevance of cavity length and drag reduction is observed, which means the stability of IFCC and FCC should be taken into consideration.

Nonastigmatic alexandrite ring laser design with wavelength-tunable single-longitudinal-mode operation

This work presents a study of a fully nonastigmatic design of a single-longitudinal-mode, wavelength-tunable, unidirectional alexandrite ring laser cavity and assessment of its performance compared to more complex laser design requiring astigmatism compensation. A “displaced mode” nonastigmatic laser cavity design eliminating astigmatic cavity elements is developed around an alexandrite crystal end-pumped by a low-brightness, high-power red diode laser pump system. Single-longitudinal-mode, continuous-wave operation is demonstrated with output power of 700 mW with an excellent T E M 00 mode ( M 2 < 1.1 ) across a wide pump power range. Wavelength tuning from 748–773 nm is produced using a birefringent filter plate. The nonastigmatic alexandrite laser design achieves better spatial quality and resilience to maintain T E M 00 operation across wide variation in pump-induced lensing compared to the astigmatic design. To the best of our knowledge, this is the first wavelength-tunable, single-longitudinal-mode operation of a unidirectional alexandrite ring system in a fully nonastigmatic cavity regime.

Dispersive Instabilities in Passively Mode-Locked Integrated External-Cavity Surface-Emitting Lasers

We analyze the dynamics of passively mode-locked integrated external-cavity surface-emitting Lasers (MIXSELs) using a first-principle dynamical model based upon delay algebraic equations. We show that the third order dispersion stemming from the lasing micro-cavity induces a train of decaying satellites on the leading edge of the pulse. Due to the nonlinear interaction with carriers, these satellites may get amplified thereby destabilizing the mode-locked states. In the long cavity regime, the localized structures that exist below the lasing threshold are found to be deeply affected by this instability. As it originates from a global bifurcation of the saddle-node infinite period type, we explain why the pulses exhibit behaviors characteristic of excitable systems. Using the multiple time-scale and the functional mapping methods, we derive rigorously a master equation for MIXSELs in which third order dispersion is an essential ingredient. We compare the bifurcation diagram of both models and assess their good agreement.

Internal flows of ventilated partial cavitation

Our study provides the first experimental investigation of the internal flows of ventilated partial cavitation (VPC) formed by air injection behind a backward-facing step. The experiments are conducted using flow visualization and planar particle image velocimetry (PIV) with fog particles for two different cavity regimes of VPC, i.e., open cavity (OC) and two-branch cavity (TBC), under various range of free stream velocity (U) and ventilation rates (Q). Our experiments reveal similar flow patterns for both OC and TBC, including forward flow region near the air-water interface, reverse flow region, near-cavitator vortex, and internal flow circulation vortex. However, OC internal flow exhibits highly unsteady internal flow features, while TBC internal flow shows laminar-like flow patterns with a Kelvin-Helmholtz instability developed at the interface between forward and reverse flow regions within the cavity. Internal flow patterns and the unsteadiness of OC resemble those of turbulent flow separation past a backward-facing step (BFS flow), suggesting a strong coupling of internal flow and turbulent external recirculation region for OC. Likewise, internal flow patterns of TBC resemble those of laminar BFS flow, with the presence of unsteadiness due to the strong velocity gradient across the forward-reverse flow interface. The variation of the internal flow upon changing U or Q is further employed to explain the cavity regime transition and the corresponding change of cavity geometry. Our study suggests that ventilation control can potentially stabilize the cavity in the TBC regime by delaying its internal flow regime transition from laminar-like to highly unsteady.

Electron self-injection threshold for the tandem-pulse laser wakefield accelerator

A controllable injection scheme is key to producing high quality laser-driven electron beams and x rays. Self-injection is the most straightforward scheme leading to high current and peak energies but is susceptible to variations in laser parameters and target characteristics. In this work, improved control of electron self-injection in the nonlinear cavity regime using two laser-pulses propagating in tandem is investigated. In particular, the advantages of the tandem-pulse scheme in terms of injection threshold, electron energy, and beam properties in a regime relevant to betatron radiation are demonstrated. Moreover, it is shown that the laser power threshold for electron self-injection can be reduced by up to a factor of two compared to the standard, single-pulse wakefield scheme.

Nonclassical properties and entanglement generation in an optical cavity containing two atomic Bose–Einstein condensates

We consider the model of a weakly driven optical cavity containing two clouds of atomic Bose–Einstein condensates (BECs). Nonclassical photon correlations and correlations between the two atomic BECs are investigated under different cavity conditions including strong atom-field coupling and bad cavity regime. We show that the nonlinear interatom collisional interactions in BEC leads to a significant loss of cavity light coherence. Various types of nonclassical properties are investigated such as sub-Poissonian statistics, antibunching and entanglement. We show that the entanglement can be generated between BECs and the cavity field. The time evolution of entanglement is also numerically studied.