An active cavitation suppression structure with jet holes on its surface is proposed for a typical hydrofoil (NACA66 MOD). Based on the homogeneous equilibrium model and the Zwart-Gerber-Belamri cavitation model, the cavitation characteristics around the hydrofoil before and after jet holes are provided on hydrofoil surface at a typical operating condition are investigated through simulation. Simulation results show that the jet holes on hydrofoil surface are capable of regulating and controlling the cavitation flow field, and to a certain extent, the jet holes on hydrofoil suction surface inhibit the development and shedding of cavitation. Four groups of different jet flow rates are set up, and it is found that with the increase of jet flow rate, the cavitation suppression effect gradually increases, and the lift-to-drag ratio gradually decreases. The research shows that the jet can achieve a cavitation suppression effect of 69.35% under the premise of ensuring that the range of hydrodynamic performance does not exceed 5%. By coupling the distribution of cavitation shape, re-entrant jet and pressure field of a hydrofoil with fluid flowing around and studying the periodic change of flow field, the mechanism of the jet to suppress cavitation is analyzed.