Cavitation In Solids Research Articles

Interfacial cavitation.

Cavitation has long been recognized as a crucial predictor, or precursor, to the ultimate failure of various materials, ranging from ductile metals to soft and biological materials. Traditionally, cavitation in solids is defined as an unstable expansion of a void or a defect within a material. The critical applied load needed to trigger this instability -- the critical pressure -- is a lengthscale independent material property and has been predicted by numerous theoretical studies for a breadth of constitutive models. While these studies usually assume that cavitation initiates from defects in the bulk of an otherwise homogeneous medium, an alternative and potentially more ubiquitous scenario can occur if the defects are found at interfaces between two distinct media within the body. Such interfaces are becoming increasingly common in modern materials with the use of multimaterial composites and layer-by-layer additive manufacturing methods. However, a criterion to determine the threshold for interfacial failure, in analogy to the bulk cavitation limit, has yet to be reported. In this work, we fill this gap. Our theoretical model captures a lengthscale independent limit for interfacial cavitation, and is shown to agree with our observations at two distinct lengthscales, via two different experimental systems. To further understand the competition between the two cavitation modes (bulk versus interface), we expand our investigation beyond the elastic response to understand the ensuing unstable propagation of delamination at the interface. A phase diagram summarizes these results, showing regimes in which interfacial failure becomes the dominant mechanism.

Gas-stabilizing solid cavitation nuclei for systemic or transdermal ultrasound-enhanced drug and vaccine delivery and immunomodulation

Originally developed for diagnostic purposes and already approved for clinical use, lipid and protein-shelled microbubbles were a natural choice as initial nucleation agents for cavitation-based therapies entering the clinic. However, several emerging therapeutic ultrasound applications require nuclei that: (i) are significantly smaller in size, in order to overcome a particular biological barrier such as the leaky vasculature of tumours or the stratum corneum; (ii) offer greatly increased cavitation persistence, both during a single extended ultrasound pulse and in terms of extended circulation following intravenous administration; (iii) have better resilience to sudden ambient pressure changes in order to enable direct injection without nuclei destruction into tissue targets via a needle and syringe; and (iv) are made of materials or have an increased payload or surface area that can interact beneficially with the relevant tissue target during or following cavitation. Gas-stabilizing solid particles will be reviewed in this context, providing an overview of their known characteristics in terms of size distribution, associated acoustic emissions, cavitation thresholds, cavitation persistence and circulation. The relationship between this acoustic characterization and associated bioeffects including drug and vaccine delivery, and immunomodulation will subsequently be explored.

Investigating the Acoustic Response and Contrast Enhancement of Drug-Loadable PLGA Microparticles with Various Shapes and Morphologies

Polymer nanoparticles and microparticles have been used primarily for drug delivery. There is now growing interest in further developing polymer-based solid cavitation agents to also enhance ultrasound imaging. We previously reported on a facile method to produce hollow poly(lactic-co-glycolic acid) (PLGA) microparticles with different diameters and degrees of porosity. Here, we investigate the cavitation response from these PLGA microparticles with both therapeutic and diagnostic ultrasound transducers. Interestingly, all formulations exhibited stable cavitation; larger porous and multicavity particles also provided inertial cavitation at elevated acoustic pressure amplitudes. These larger particles also achieved contrast enhancement comparable to that of commercially available ultrasound contrast agents, with a maximum recorded contrast-to-tissue ratio of 28 dB. Therefore, we found that multicavity PLGA microparticles respond to both therapeutic and diagnostic ultrasound and may be applied as a theranostic agent.

Superhydrophobic drug-loaded mesoporous silica nanoparticles capped with β-cyclodextrin for ultrasound image-guided combined antivascular and chemo-sonodynamic therapy

Interfacial nanobubbles (INBs) on a superhydrophobic surface has been proposed as a solid cavitation agent for enhancing inertial cavitation dose and ultrasound contrast imaging, but the dispersibility of superhydrophobic particles limits the biomedical application. For this study, we designed superhydrophobic mesoporous silica nanoparticles loaded with the anti-tumor drug Doxorubicin (FMSNs-Dox) for tumor therapy. The β-cyclodextrin was used to cap the superhydrophobic surface of FMSNs-Dox to reduce aggregation without inhibiting the accumulation of INBs. The mean size and a contact angle of FMSNs-Dox was 217 ± 58 nm and 129 ± 3°, respectively. The INBs cavitation on the surface of FMSNs-Dox during ultrasound sonication disrupted tumor vessels to allow a large amount of drug penetrating and trapping within tumors. The reduced tumor perfusion, histological reactive oxygen species staining, and tumor inhibition demonstrated that FMSNs-Dox sonication combined anti-vascular, sonodynamic and chemical therapies in a simple platform. Moreover, the repeatability of INB cavitation by single-injection FMSNs-Dox with multiple ultrasound sonication provided intratumoral ultrasound contrast-enhanced imaging from day 1–9 (enhancement of 3.84 ± 0.47 dB). Therefore, the characteristics of FMSNs-Dox with slow biodegradation and acoustic-sensitivity presented intratumoral day-scaled lifetime to provide a probability of repeated combination therapy by single-injection.

Biomedical Applications for Gas-Stabilizing Solid Cavitation Agents.

For over a decade, advancements in ultrasound-enhanced drug delivery strategies have demonstrated remarkable success in providing targeted drug delivery for a broad range of diseases. In order to achieve enhanced drug delivery, these strategies harness the mechanical effects from bubble oscillations (i.e., cavitation) of a variety of exogenous cavitation agents. Recently, solid cavitation agents have emerged due to their capacity for drug-loading and sustained cavitation duration. Unlike other cavitation agents, solid cavitation agents stabilize gaseous bubbles on hydrophobic surface cavities. Thus, the design of these particles is crucial. In this Review, we provide an overview of the different designs for solid cavitation agents such as nanocups, nanocones, and porous structures, as well as the current status of their development. Considering the numerous advantages of solid cavitation agents, we anticipate further innovations for this new type of cavitation agent across a broad range of biomedical applications.

A device to fracture soft solids at high speeds

We describe the development of a device for high-rate, pneumatic fracture. The Small-scale Ballistic Cavitation (SBC) device uses a high pressure reservoir to generate cavities within ultrasoft solids (moduli < 100 kPa) in bursts as short as 5 ms. Flow accelerates through a needle embedded within a soft solid, reaching the speed of sound at the tip before delivery to the sample. The energy density of the air pulse matches that of handgun projectiles, enabling ballistic-like temporary cavities, but on a benchtop scale. We validate the device using mass transfer measurements and find good agreement without the use of fit parameters between experiments and theory at the required operational pressures ranging from ∼30 to 160 atm. Independent control of pressure, needle diameter, and valve cycle time provides flexibility in experimental control variables (e.g., energy density, rate) that is not present in other ultrasoft solid cavitation techniques. We demonstrate the device’s experimental flexibility via the application of constant energy density with variable loading rate conditions that illustrate the importance of rate on fracture morphology in soft solids.

A mechanical model on elastic cavitation in solid under hydrostatic tension

In this paper, a mechanical model is proposed to study cavitation in solids. The material is elastic and obeys Hook's law. Logarithm strain and Cauchy stress in nonlinear elasticity is used. A sphere with a central hole is loaded under hydrostatic tension on surface. In spherical symmetry, closed form solution is got. As radius of the hole tends to zero, a pitchfork bifurcation appears on load-displacement curve. The pitchfork bifurcation indicates that there is a cavitation at center of solid sphere as load reaches a critical value.