Patient safety of Veterans, including prevention of healthcare-associated infections, is a priority in VHA. The use of medical devices such as urinary and intravenous catheters, and endotracheal tubes is a routine part of care in the intensive care unit (ICU), as well as in acute care (non-ICU), and long term care (LTC). While such devices are a vital part of lifesaving measures, they also compromise patient safety by increasing risk of infection. In 2006, VHA began introducing initiatives to reduce device-associated infection (DAI) rates in all VHA facilities nationwide. Infection prevention bundles, focusing recommendations from evidence-based practices, for reduction of catheter-associated infections (CAUTI), central line associated bloodstream infections (CLABSI) and ventilator associated pneumonias (VAP) were employed. Quality improvement methods to address DAIs included national teleconference calls and development and dissemination of toolkits which provided criteria for defining infections, goal-setting, and mentoring of sites challenged to meet goals. Senior leadership at all levels was supportive of the initiatives. A web-based data management tool was developed to facilitate data collection and currently remains the primary method for tracking infection rates for ICU, non-ICU and LTC settings. See Table. Implementation of infection prevention bundles for DAIs has resulted in a statistically significant reduction in CAUTI, CLABSI, and VAP rates in VHA facilities. While the ICU was originally targeted beginning in 2006, the initiative was expanded to the non-ICU and LTC over the past nine years with equivalent success.