Problem: Floseal is a novel matrix hemostatic sealant composed of collagen-derived particles and topical bovine-derived thrombin. It is applied as a high viscosity gel for hemostasis. This study is a prospective, randomized, controlled clinical trial of Floseal sealant compared to traditional suction cautery hemostasis in children undergoing adenoidectomy. Methods: Seventy patients (mean age, 7.0 years; 45.7% male) with obstructive sleep apnea underwent traditional cold steel adenoidectomy and were then randomized to receive Floseal or cautery to obtain hemostasis. Patients were crossed over to the other technique after more than 100 mL blood loss or 15 minutes had elapsed. Objective data collected included time to hemostasis and blood loss during hemostasis. Visual analog scales (VAS) were used to record subjective data by the operating surgeon including bleeding following pack removal (0 = none, 4 = brisk) and ease of operation (1 = difficult, 6 = easy). Parents were contacted by phone at day 7 and questioned with regard to return to diet and narcotic usage. Results: Floseal patients (n = 35) had significantly shorter times to hemostasis (0.6 minutes vs 9.3; P < 0.001), less blood loss (2.5 vs 29.5 mL; P < 0.001), less subjective bleeding (0.0 vs 2.0; P < 0.001), and subjectively easier operations (2.6 vs 5.2 [mean 6-point VAS], P < 0.001). Furthermore, Floseal patients returned to regular diet earlier (2.7 vs 4.1 days, P < 0.001) and had less use of narcotics at 7 days (43% vs 69%). Finally, 3 patients in the cautery group (n = 35) were crossed over to the Floseal group. Floseal resulted in a cost savings of $104/operation. Conclusion: Floseal sealant is a safe, effective, easy, and cost-conscious technique for obtaining hemostasis in children undergoing adenoidectomy. Significance: Floseal sealant is a good tool in the armamentarium of surgeons who encounter heavy bleeding during adenoidectomy. Support: None reported.
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