Cause Of Women Research Articles

Treatment of Leptomeningeal Metastases from Breast Cancer: A Literature Review

Breast cancer (BC), owing to its high prevalence, represents one of the leading causes of women’s death worldwide. Due to remarkable progress in therapy directed against this malignant neoplasm, there was an increase in the survival of affected patients and, therefore, a rise in the number of central nervous system metastases (CNSM) – up to twenty percent, located in the leptomeninges. There is not enough evidence of the therapeutic options for treating leptomeningeal metastases (LM) from breast cancer in the medical literature, and the management of these patients is complex. Even with an aggressive approach, therapeutic outcomes are uniformly disappointing due to the relentless growth of the central nervous system and systemic cancer or their lethal complications. The development of management strategies for CNSM constitutes an important clinical challenge and more prospective trials are needed to better address the impact of the available treatment on overall survival and quality of life. This article aims to provide an overview of the current established treatment for LM from BC, a rare complication of metastatic breast cancer (MBC), with high morbidity and mortality rates.

Prognostic impact of elevated C-reactive protein and procalcitonin in patients with extensive-stage small cell lung cancer.

Small cell lung cancer (SCLC) constitutes around 15% of lung cancer cases and stands as the primary cause of cancer-related fatalities in men and the second leading cause in women globally. In this study, our objective was to evaluate the levels of C-reactive protein (CRP) and procalcitonin (PCT) in newly diagnosed extensive-stage SCLC patients without evidence of infection. We aimed to demonstrate that elevated CRP and PCT levels may not solely indicate infection but could also be elevated in malignancies. Furthermore, we sought to correlate these marker levels with patient and disease characteristics to elucidate the relationship between these inflammation markers and disease progression. A total of 115 patients who were pathologically and radiologically diagnosed with extensive-stage SCLC between January 2020 and December 2022 and who had received no prior treatment were included in the study. The Kaplan-Meier analysis revealed a median progression-free survival (PFS) of 7.46 months [95% confidence interval (CI), 6.85-8.07] and a median overall survival (OS) of 10.50 months (95% CI, 8.69-12.30) for all patients. In the group with elevated PCT, the median PFS was 6.73 months (95% CI, 3.92-9.54), whereas it was 7.86 months (95% CI, 7.13-8.59) in the group with normal PCT (P = 0.002). Similarly, the median OS was 9.10 months (95% CI, 5.61-12.58) in the elevated PCT group and 11.66 months (95% CI, 9.59-13.74) in the normal PCT group (P = 0.006). Patients with elevated procalcitonin (PRC) levels at the time of diagnosis exhibited shorter PFS and OS durations compared to patients with normal PRC levels. Furthermore, elevated CRP has also been demonstrated to correlate with poorer prognosis in extensive-stage SCLC.

A Call for Rigorous Research Investment in women's Health.

Worldwide, women face a disproportionately heavy health burden than their male counterparts. Yet there is a chronic lack of research attention and investment in women's health, which may explain the absence of women-inclusive, let alone women-centred, understanding of the causes, consequences, and confounding factors that shape individuals' health and quality of life. In this manuscript, by analysing the U.S. National Health Expenditure data, we show how ingrained the issue of poor investment in women's health even in the 0-18 years age group in terms of per capita health expenditure. We hope this manuscript sheds light on how early-life poor health investment in women's health might be a potential cause for women's poor health in adulthood, and in turn, underscores the importance of investing resources into better understanding and improving women's health.

Relationship between knowledge and attitude about human papillomavirus infection and vaccination in female nursing students

Introduction: Human papillomavirus (HPV) infection is the primary cause of cervical cancer, which is the second-leading cause of women’s death in Indonesia, and that is why a national HPV vaccination program is required to address this issue. A preliminary survey of 20 female nursing students revealed that 70% were unaware of the HPV virus, 80% were unaware of cervical cancer, and 80% were unaware that HPV could lead to cervical cancer. This study aimed to determine the relationship between knowledge and attitude about human papillomavirus infection and vaccination in female nursing students. Methods: This descriptive-quantitative study used a cross-sectional design and univariate and bivariate analysis.

Abstract B040: Investigating the impact of tumor EMT states on immune cell infiltration in breast cancer

Abstract Breast cancer is one of the most frequently diagnosed cancers and the second leading cause of women’s cancer death. Although the five-year survival rate for women in the United States with nonmetastatic invasive breast cancer is 90%, this rate drops to less than 30% for those with tumors that have metastasized to distant organs. Epithelial-to-Mesenchymal Transition (EMT) plays a critical role in tumor metastasis by enabling the loss of epithelial characteristics and the gain of mesenchymal traits, leading to increased cell motility, invasion, and resistance to therapy. Consequently, targeting the EMT process may prevent tumor cell migration and improve patient outcomes. Rather than being a binary switch from an epithelial to a mesenchymal state, cells undergoing EMT can assume a spectrum of intermediate states, some of which may reshape the tumor microenvironment by recruiting pro-tumor immunosuppressive cells, such as regulatory T cells, M2-like macrophages, and myeloid-derived suppressor cells. However, the impact of EMT on the immune composition of the tumor microenvironment and the causative mechanisms remain poorly understood. Using multi-omics approaches in a mouse model of triple-negative breast cancer, we assessed the interaction between tumor and immune cells in the tumor microenvironment driven by the EMT. A heterogeneous mouse breast cancer cell line (4T1) was used to isolate five distinct single-cell-derived clonal populations residing in distinct states within the EMT spectrum. These EMT clones, along with the parental 4T1 cell line, were orthotopically transplanted into the mammary fat pads of BALB/c mice. Primary tumors were subsequently harvested and dissociated for single-cell RNA-sequencing (scRNA-seq) and DNA methylation analysis. Lungs were histologically evaluated for metastases. Tumors derived from an intermediate EMT clone exhibited increased tumor growth kinetics and a higher incidence of metastasis compared to epithelial or mesenchymal clones. In scRNA-seq data, tumors derived from different EMT clones largely retained their original EMT states in vivo and recruited distinct immune cell profiles. DNA methylation analysis further revealed that these tumors displayed unique methylation patterns in EMT-related CpGs. This study introduced a model that captures the complexity of the tumor microenvironment across the EMT spectrum. This was accomplished through immunophenotyping using scRNA-seq and identifying unique epigenetic patterns through DNA methylation. Our findings highlight the potential for distinct immune cell populations to be recruited to tumors in different EMT states, thereby influencing survival and metastasis outcomes. Furthermore, our results open new opportunities for developing cancer combination treatment strategies that target specific tumor-immune cell interactions. Citation Format: Hanxu Lu, Meisam Bagheri, Todd Miller, Diwakar Pattabiraman, Brock Christensen. Investigating the impact of tumor EMT states on immune cell infiltration in breast cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor-body Interactions: The Roles of Micro- and Macroenvironment in Cancer; 2024 Nov 17-20; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2024;84(22_Suppl):Abstract nr B040.

Advanced 2D Nanomaterials for Phototheranostics of Breast Cancer: A Paradigm Shift.

Breast cancer is the leading cause of women's deaths and associated comorbidities. The advanced and targeted strategies against breast cancer have gained considerable attention due to their potential enhanced therapeutic efficacy over conventional therapies. In this context, phototherapies like photodynamic therapy (PDT) and photothermal therapy (PTT) have shown promise as an effective and alternative strategy due to reduced side effects, noninvasiveness, and spatiotemporal specificity. With the advent of nanotechnology, several types of nanomaterials that have shown excellent prospects in increasing the efficacy of photo therapies have been exploited in cancer treatment. In recent years, 2D nanomaterials have stood out promising because of their unique ultrathin planar structure, chemical, physical, tunable characteristics, and corresponding remarkable physiochemical/biological properties. In this review, the potential and the current status of several types of 2D nanomaterials such as graphene-based nanomaterials, Mxenes, Black phosphorous, and Transition Metal Dichalcogenides for photo/thermo and combination-based imaging and therapy of breast cancer have been discussed. The current challenges and prospects in terms of translational potential in future clinical oncology are highlighted.

Inherited kidney disease and CAKUT are common causes of kidney failure requiring kidney replacement therapy: an ERA Registry study.

Inherited kidney diseases (IKD) and congenital anomalies of the kidney and urinary tract (CAKUT) are causes of kidney failure requiring kidney replacement therapy (KRT) that major renal registries usually amalgamate into the primary renal disease (PRD) category 'miscellaneous' or in the glomerulonephritis or pyelonephritis categories. This makes IKDs invisible (except for polycystic kidney disease) and may negatively influence the use of genetic testing, which may identify a cause for IKDs and some CAKUT. We have re-examined the etiology of KRT by composing a separate IKD and CAKUT PRD group using data from the European Renal Association (ERA) Registry. In 2019, IKD-CAKUT was the fourth most common cause of kidney failure among incident KRT patients, accounting for 8.9% of cases (IKD 7.4% [including 5.0% ADPKD], CAKUT 1.5%), behind diabetes (23.0%), hypertension (14.4%) and glomerulonephritis (10.6%). IKD-CAKUT was the most common cause of kidney failure among patients younger than 20 years (41.0% of cases), but their incidence rate was highest among those aged 45-74 years (22.5 per million age-related population). Among prevalent KRT patients, IKD-CAKUT (18.5%) and glomerulonephritis (18.7%) were the two most common causes of kidney failure overall, while IKD-CAKUT was the most common cause in women (21.6%) and in patients younger than 45 years (29.1%). IKD and CAKUT are common causes of kidney failure among KRT patients. Distinct categorization of IKD and CAKUT better characterizes the epidemiology of the causes of chronic kidney disease, and highlights the importance of genetic testing in the diagnostic workup of CKD.

What Happens after Nora Walks Out?——Take Regret for the Past and A Room of One’s Own as Examples to Analyze Female Liberation

At the commencement of the 20th century, concurrent with the transformation of the socioeconomic structure and the augmentation of individualistic consciousness, the feminist narrative in both the Eastern and Western contexts grew increasingly assertive. The character Nora in Ibsen’s plays significantly contributed to the consciousness awakening among women. Regret for the Past can serve as a sequel to What Happens after Nora Walks Out? Delineating the roads and ultimate fate of a consciousness-awakened woman. Concurrently, the eminent Western author, Virginia Woolf, initiated an exploration of feminism within the narrative of A Room of One’s Own marking a significant juncture in the Western feminist movement’s trajectory. This scholarly work involves a meticulous exegesis of the literary texts within Regret for the Past and A Room of One’s Own, examining the diverse experiences of women’s liberation across various historical periods. Research indicates that the status of women has enhanced subsequent to societal emancipation, with women’s liberation being concomitant with their endeavor for gender equality. Subsequently, the Women’s Liberation Movement has achieved additional advancements. It is incontrovertible that research has demonstrated the necessity of social emancipation as a prerequisite for the advancement of women’s liberation. Presently, given the enhancement of women’s societal standing, when running away from home, which had been given the meaning of awakening, was no longer the only option. What contemporary avenues are available for women and what novel challenges confront the cause of women’s liberation?

Deconstruction Of The Meaning Of Polygamy In Women's Perspective In The Movie “Atas Nama Surga”

This study deconstructs the meaning of polygamy in the film “Atas Nama Surga” as an act of assertiveness by women `who reject polygamy, signifying the importance of maintaining women's strength and dignity. This study emphasizes women's perspectives, providing awareness of the importance of having the courage to speak one's mind. The research method uses a qualitative literature study with movie analysis from the MAXstream platform as primary data, and journals, books, articles, and online sources as secondary data. The results identify the deconstruction of polygamy as a cause of women's suffering, the potential for violence, and as a form of male selfishness. Factors such as experience, knowledge, and economic power influence the emergence of this deconstruction of meaning. The implications include stereotyping men as violent and selfish, polygamy being perceived as material control, and the difficulty of realizing a monogamous marriage. Despite the limited focus on one movie, this research provides a basis for extending the deconstruction to other works.

Case Study — Breaking Barriers: Women Empowerment in a Conservative Society

Muhammad Ali Mugheri (Mr. Mugheri), a Pakistani high school teacher, had to overcome crucial obstacles to change the mindset of the school management, the government, and the society — a male-dominated environment conserved in laws and culture for girls’ education. For the first time in history, such a change agent highlighted how the male gender faced issues on the way of bringing a positive change in the conservative society of Sindh, Pakistan. His educational background and work experience led him to rapid progression from the role of a girls’ high school teacher to a headmaster in the primary girls’ school to a boys’ high school teacher. After more than 14 years of working as a teacher and a headmaster, he struggled for female education in the conservative society and negligent government. As he reflected on the hard journey he had been through, although he was sincere and dedicated, he wondered what was next? In 2022, Mr. Mugheri faced yet a tough decision to change the workplace under pressure from authorities; if so how would he continue working for the cause of women’s education? In September 2022, Mr. Mugheri was confronted with another setback challenging a serious threat to his mission of fighting for girls’ right to education. As a school headmaster, he aimed for many positive changes to bring but he felt cornered. He contemplated on the challenging times he had seen to reach this point of time. Mr. Mugheri was passionate about the success of girls’ education in a conservative society. For a man, staying for long in the girls’ school, be it government girls higher secondary school or primary girls school, was a distant reality. Considering the challenges, he wondered if he could continue as a head of school, or was it time for him to change? Mr. Mugheri was the headmaster in the girls’ primary school, Lalu Raunk, Sindh, Pakistan. All his staff were female teachers. This was not acceptable to many in the conservative societies. The community heads and parents raised their concerns for his appointment in a girls’ school. Nonetheless, due to his earlier contributions to the schools, he could continue following his passion. He was greatly respected for his charismatic leadership style and his outstanding work on female education. He attributed his superior performance in the education sector to his drive, unwavering motivation to work, passion for female education, and tough decisions he had made in his career. “Give me an educated mother and I will give you an educated nation” the quote he stated repeatedly.

A Review on Design of Coumarin Hybrids in the Treatment of Breast Cancer

The breast cancer is one of most prevalent cancer in women, and after lung cancer, it is the second greatest death cause in women. From previous years, progress has been made and continues to be made in the breast cancer vaccines development. It is a great approach to create hybrid compounds by combining distinct pharmacophores to gain important biological activity. The use of coumarin in conjunction with other themes has resulted in the creation of novel strategies to combat breast cancer. Coumarin has been shown in reviewed literature to be a potent antidote for breast cancer, binding to different biological targets linked to the disease. The hybrids of Coumarin have recently gained the notice of researchers who want to investigate their therapeutic potential in the treatment of breast cancer due to their minimal toxicity in multiple organ systems. Interactions with isoxazoles, thiazoles, monastrol, chalcone, triazole, sulphonamide, and other coumarin strains have been reported. The definitions of the different coumarin compounds, as well as their structural connections, are described in this review article.

Association of MTR and MTRR polymorphisms with recurrent pregnancy loss: a case control study.

In light of several epidemiological studies, the etiology of recurrent pregnancy loss is complex. One of the most frequent causes of women experiencing inexplicable recurrent pregnancy loss is maternal thrombophilia. Hence, the association between genetic polymorphisms causing thrombophilia and recurrent pregnancy loss needs to be explored. Is to study the relation of polymorphisms affecting folate pathway mainly, 5-Methytetrahydrofolate-Homocysteine Methyltransferase (MTR A2756G) and 5-Methytetrahydrofolate-Homocysteine MethyltransferaseReductase (MTRR A66G) with recurrent pregnancy loss. It is a case-control study. Four hundred participants were enrolled. Two hundred participants with unexplained recurrent pregnancy loss (case group) and two hundred healthy fertile participants (control group). All participants were screened for (MTR A2756G) and (MTRR A66G). DNA was extracted using salting out method followed by genotyping via Real-time PCR. Mutant homozygous genotype (GG) in MTRR A66G was statistically significantly among RPL group in comparison to controls. (GG vs. AA) had odds ratio and confidence interval of 1.22(1.12-2.23), P = 0.012. (GG) increased the liability 1.2 folds for recurrent pregnancy loss. Mutant homozygous genotype (GG) in MTR A2756G was not correlated with the risk of recurrent pregnancy loss. (GG vs.AA) = (1.13(0.56-2.29)), P = 0.7 CONCLUSION: MTRR A66G increases susceptibly for recurrent pregnancy loss among Egyptian women.

Causal Attributions of Low Sexual Desire in Women Partnered with Men.

Low sexual desire in women partnered with men has been the subject of controversy and research over the past decades, including both as construct and diagnosis. Despite discussion surrounding the causes of low desire, there is a gap in research about how women themselves understand the causes of their low desire and the potential consequences of these causal attributions. In the current study, we investigated this by asking 130 women who had low desire and were partnered with men about their attributions for low desire. Through content analysis, we identified five attribution categories: psychological/individual, relational, biological, sociocultural, and/or sexual orientation/identity/status. Many participants chose more than one category, indicating a multifaceted nature of women's causes of low desire. We then quantitatively assessed women's feelings of responsibility for, and emotions surrounding, their low desire. Our findings indicate that the majority-but not all-of women have negative feelings about their low desire. However, the specific emotions they experience are related to their attribution patterns. This underscores the significance of investigating various facets of women's attributions regarding low desire in order to gain a more comprehensive understanding of their emotional experiences and desire overall.

How gender differences in informal networking result in unequal access to interorganizational R&D projects

Women are underrepresented in interorganizational research & development (R&D) projects. This affects the innovativeness of such projects, the representation of female perspectives in the design of innovations and the career opportunities of women. Such projects often emerge from preceding interorganizational R&D projects and are particularly successful when they do so. We argue that instrumental networking in ongoing projects is constitutive for the formation of such follow-up collaborations and, further, that stereotypical gender roles hinder women’s participation in instrumental interactions with their current project partners. Hence, we assume that unequal opportunities to participate in follow-up projects can be attributed to women’s lesser involvement in instrumental networks. Empirically, we test our argument using data on 2746 directed and weighted personal relationships across 24 interorganizational R&D projects. We show that instrumental interactions are crucial for who initiates follow-up projects with which current partner. Furthermore, we can show that the low participation of women in these activities can be better explained by gender roles than by gender homophily. In doing so, we reveal an important cause of women's under-representation in R&D.

Dalit Feminism: Historical Context And Impact

Dalit feminism aims to dismantle the prevailing narratives that uphold their oppression by empowering Dalit women to express their agency and reclaim their stories. Notwithstanding casteist violence and persecution, Dalit women have always been important voices for their rights and dignity. Prominent individuals such as Jyotiba Phule, Savitribai Phule, and Ramabai Ambedkar have played a pivotal role in the anticaste and anti-untouchability campaigns in India, championing the cause of women's empowerment and education rights. Organizations like the Dalit Mahila Samiti and the All India Dalit Mahila Adhikar Manch (AIDMAM) sought to address problems including domestic abuse, healthcare access, and sexual exploitation of Dalit women in the 20th century. Dalit feminism also criticizes mainstream feminism for failing to represent the experiences of women from lower castes and for being dominated by upper-class viewpoints. It aims to elevate Dalit women in the feminist conversation and promotes unity with other oppressed groups, such as LGBTQIA+ people and males of lower castes.

Demographics and ultrasonography findings of mastalgia in a tier 2 city of India

Background: Breast pain is the second most common breast symptom (after breast lump) for which women seeks medical attention. Breast pain can affect daily life, including sleeping, or physical, social, and work-school life. Mastalgia is one of the common causes for women in tier 2 city visiting health care facility but there are only few studies which focus on demographic findings and ultrasonographic findings in mastalgia. Aims and Objectives: The objective of this study was to study demographics of breast pain in a tier 2 city and ultrasound evaluation of mastalgia. Materials and Methods: In this prospective study, 143 patients presenting with mastalgia irrespective of focality, duration, or cyclical nature were included. In these patients, we studied demographic profile and ultrasonographic findings in mastalgia. Results: About 37% women were in 20–29 years of age group and least number was in 70–79 years of age group. About 86% of women in our study were in reproductive age group. Most patient with mastalgia have associated palpable lump (58%) followed by 43% patients with mastalgia and nipple discharge, only 27% of patients have mastalgia alone whereas 4% women have pain with skin changes. The majority (49%) of mastalgia cases fall under the breast imaging-reporting data system (BI-RADS)-I category while cases in BI-RADS-IV and V category were 2 and 1, respectively. Conclusion: Women in their reproductive age group and in their 3rd decade of life are more prone for mastalgia. Ultrasonography is also helpful in detecting cancers in setups where routine mammography is not possible.

ED diagnosis of peritoneal carcinomatosis

PurposeThe goal of our study was to better characterize new CT diagnoses of peritoneal carcinomatosis (PC) in the ED, and to evaluate how to best identify the primary lesion. Prompt identification of the source of the carcinomatosis may allow for the patient to receive early initial care from the correct clinical service.MethodsAll new CT cases of PC-like appearance identified on CT in the ED from January 2017 through July 2020. Each report and corresponding medical record were manually reviewed. Patient demographics, presence/absence of intravenous contrast, source organ predicted by the radiologist in the CT scan report, pathologic diagnosis, and amount of ascites were tabulated. Chi-tests were used to test the statistical significance of differences between groups.ResultsOf the 131 CT cases of new PC-like appearance which received workup, 108 cases had pathologically proven PC and 23 cases had no underlying malignancy yielding a positive predictive value for actual PC of 82%. The most common cause of new PC in women was gynecological (66%), and in men was of GI tract origin (57%). Concordance between radiologist prediction and final pathology was higher with intravenous contrast (58%) compared to without contrast (40%); although this difference was not statistically significant (p = 0.19). A moderate or large amount of ascites was found in more than half of GYN primaries and in adenocarcinoma of unknown primary and there was a statistically significant difference in amount of ascites between cancer primaries (p = 0.01).ConclusionA PC-like appearance on CT in the ED will likely be in patients with known malignancy, but of the new cases, there is a high PPV for it to represent new peritoneal carcinomatosis. Gynecological and GI malignancies are the most common cause in women and men, respectively, and this may help in focusing the radiologist’s search pattern. Usage of intravenous contrast may help in identifying a primary lesion, and the presence of high-volume ascites should suggest a GYN primary or adenocarcinoma of unknown primary when there is no other obvious primary lesion.

Women's health and rights in the twenty-first century.

In the twenty-first century, the complex relationship between women's health and rights has been influenced by a range of interconnected challenges, including gender inequity, reproductive health disparities, maternal mortality and morbidity, and women's inability to access life-saving, high-quality healthcare services including family planning. Going forward, the world needs to find ways to implement the unfinished agenda of the International Conference on Population and Development (ICPD) 1994 and the Sustainable Development Goals (SDGs), thus prioritizing health and rights for women and girls as essential not only to their survival but also to their progress, agency and empowerment. It is also important to consider the interconnection between women's health and rights and climate change, with its disproportionate impact on the well-being of girls and women, and to address the impact and opportunities afforded by digital technologies. By embracing a holistic approach, societies might be able to advance the cause of women's health and rights in a more inclusive and sustainable manner.

Male victims of domestic violence among professional families: Shackled in masculinity

Various acts of domestic violence are the reality that troubles family life in various social classes. This study seeks to investigate violence experienced by men among professional families and the causes of women to commit such act. This study deployed qualitative methods and conducted in-depth interviews of 53 informants. The finding of the study indicates that men not only experience single violence, but a variation of violence that occurred in professional families, such as physical, economic, verbal/psychological, and sexual violence. This study shows the triggers for women to commit violence against men among professional families are insecurity, jealousy, and inequality in socioeconomic status. Men are burdened with patriarchy and tend to be passive in reacting to the violence they experience. Masculinity makes male victims of violence suffer triple oppression: They become the victims; they are embarrassed because they get a negative stigma from the community for failing and not being able to lead their families; and when men become the victims, they ‘get punished’ because it is considered as ‘abnormal’ for men to become victims of violence. Men react to the violence committed by their wives by carrying out latent resistance, manifest resistance, and alienation.

Women Empowerment in the Digital Age : Significance of New Media

The worldwide scene was totally altered by the technological revolution brought about by new media, the internet, blogs, and social networking sites and influenced the fundamental framework of societies, fostering more conversations, arguments, and intellectual production while enhancing the democratic capacity of governments. It is widely believed that new media can be an effective tool for women's development and empowerment, moreover gives women a voice and a forum to communicate their thoughts and concerns without fear of prejudice or retaliation. Women make up a large portion of the global population, and as science and technology advance, so too does the status of women, which is changing quickly. However, we cannot deny that there is a world in which women face numerous forms of discrimination, marginalization, and oppression, new media provides innovative spaces and platforms to address and effectively overcome such discrimination. These are being developed as spaces that are democratic in nature, embodying freedom and equality, while enabling a liberal space for women to speak out. It is relevant that other spaces do not have the same potential and capacity as the new media to become women's media, even if sometimes gender inequalities exist. This paper also examines the ways in which new social media spaces are the cause of women's advancement and the challenges they face.