You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy III1 Apr 2018PD16-09 PARTIAL NEPHRECTOMY CONVERTING TO RADICAL NEPHRECTOMY: IMPACT OF PATIENT AND SURGICAL FACTORS Akbar Ashrafi, Peter Mekhail, Ricardo Brandina, Grant Redrow, Mihir Desai, Inderbir Gill, and Monish Aron Akbar AshrafiAkbar Ashrafi More articles by this author , Peter MekhailPeter Mekhail More articles by this author , Ricardo BrandinaRicardo Brandina More articles by this author , Grant RedrowGrant Redrow More articles by this author , Mihir DesaiMihir Desai More articles by this author , Inderbir GillInderbir Gill More articles by this author , and Monish AronMonish Aron More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.821AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Intraoperative conversion of partial nephrectomy to radical nephrectomy may be related to tumor complexity, patient or surgical factors. The aim of this study was to describe the causes for conversion and assess for patient and surgical predictors of conversion in patients undergoing partial nephrectomy at a high-volume academic center. METHODS We identified all patients who were scheduled to have robotic, laparoscopic or open partial nephrectomy at our institution between January 2011 and December 2014. The intraoperative reason for conversion to radical nephrectomy was collated from retrospective review of operative notes. Several variables were analyzed including, age, gender, Charlson co-morbidity score, ASA score, tumor size, procedure type, renal function and complication data. Multivariable logistic regression was used to identify independent predictors for conversion. RESULTS A total of 878 patients were scheduled for partial nephrectomy (PN). The rate of conversion to radical nephrectomy (RN) was 3.6% (n=32). The most common reasons for conversion were invasion of hilar structures in 12 patients (38%), insufficient residual kidney in 11 (35%), excessive intraoperative bleeding in 4 (13%), suspected positive margin in 2 patients (13%) and anesthesiology-related in 1 patient. Patients that were converted had similar preoperative eGFR (73 vs 79 mL/minute/1.73 m2, p=0.2), rates of diabetes (34% vs 23%, p=0.1), mean Charlson co-morbidity score (1.1 vs 1.5, p=0.2) and mean ASA score (2.3 vs 2.5, p=0.3). Patients that had conversion to RN were more likely to be older (mean age 67 vs 61, p=0.02), have hypertension (81% vs 62%, p=0.03) and have larger tumors (mean size 5.2 vs 3.2cm, p<0.01). In the robot-assisted PN group, 10 of 628 cases were converted (1.6%) compared to 4 of 45 cases in open PN (8.2%) and 18 of 173 in the laparoscopic PN group (9.4%, p<0.01). On multivariable logistic regression, tumor size (OR 1.2), hypertension (OR 2.8) and robotic surgery (OR 0.14) were independent predictors of conversion. There were no differences in the complication (3% vs 12%, p=0.2) or malignancy rate (81% vs 78%, p=0.7) though postoperative eGFR was significantly lower in patients that had conversion compared to the PN group (40 vs 65 mL/minute/1.73 m2, p<0.01). CONCLUSIONS Intraoperative conversion of partial nephrectomy to radical nephrectomy was most commonly due to invasion of hilar structures or insufficient residual kidney in this series. Conversion was associated with hypertension and larger tumor size, and increased the risk of chronic kidney disease postoperatively. Robot-assisted partial nephrectomy reduced the risk of conversion compared to the open or laparoscopic approach. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e319-e320 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Akbar Ashrafi More articles by this author Peter Mekhail More articles by this author Ricardo Brandina More articles by this author Grant Redrow More articles by this author Mihir Desai More articles by this author Inderbir Gill More articles by this author Monish Aron More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Read full abstract