The problem of postlumbar puncture headache is an exceedingly perplexing one and no solution of it has been offered so far. Theories have been advanced, but they were merely of a speculative nature not substantiated by any pathologic or experimental evidence. It is commonly known that the amount withdrawn has no bearing on the production or severity of the headache. Nor do the cytologic, serologic or chemical findings in the spinal fluid bear any relation to it. It is significant, however, that, comparatively speaking, only a small percentage of patients suffer from post-puncture headache. Early in 1923, a paper by Depisch and Richter-Quittner 1 on the etiology of headache attracted our attention. They found that a total lack of calcium in the spinal fluid or the presence of only very small amounts is the cause of headache. They determined the calcium content of spinal fluids of twenty-one patients of various