Cause Of Cervical Lymphadenopathy Research Articles

Using T2-weighted magnetic resonance imaging-derived radiomics to classify cervical lymphadenopathy in children

BackgroundCervical lymphadenopathy is common in children and has diverse causes varying from benign to malignant, their similar manifestations making differential diagnosis difficult.ObjectiveThis study aimed to investigate whether radiomic models using conventional magnetic resonance imaging (MRI) could classify pediatric cervical lymphadenopathy.MethodsA total of 419 cervical lymph nodes from 146 patients, and encompassing four common etiologies (Kikuchi disease, reactive hyperplasia, suppurative lymphadenitis and malignancy), were randomly divided into training and testing sets in a ratio of 7:3. For each lymph node, 1,218 features were extracted from T2-weighted images. Then, the least absolute shrinkage and selection operator (LASSO) models were used to select the most relevant ones. Two models were built using a support vector machine classifier, one was to classify benign and malignant lymph nodes and the other further distinguished four different diseases. The performance was assessed by receiver operating characteristic curves and decision curve analysis.ResultsBy LASSO, 20 features were selected to construct a model to distinguish benign and malignant lymph nodes, which achieved an area under the curve (AUC) of 0.89 and 0.80 in the training and testing sets, respectively. Sixteen features were selected to construct a model to distinguish four different cervical lymphadenopathies. For each etiology, Kikuchi disease, reactive hyperplasia, suppurative lymphadenitis, and malignancy, an AUC of 0.97, 0.91, 0.88, and 0.87 was achieved in the training set, and an AUC of 0.96, 0.80, 0.82, and 0.82 was achieved in the testing set, respectively.ConclusionMRI-derived radiomic analysis provides a promising non-invasive approach for distinguishing causes of cervical lymphadenopathy in children.Graphical

Cytological Findings of Fine Needle Aspiration Cytology in Diagnosing Causes of Cervical Lymphadenopathy in Patients Attending Health Care Facilities of Janakpur, Nepal

Background & Objectives: Fine Needle Aspiration Cytology (FNAC) is a minimally invasive and inexpensive procedure that produces a rapid result. As cervical lymphadenopathies are common clinical findings with varied causes, FNAC may have an extremely important role in the diagnosis of various underlying clinical condition. Materials and Methods: A prospective multicentric study was conducted from September 2021 to June 2023 at Janakpur, Nepal. A total of 60 cases were included in the study. The procedure was performed in the cervical lymph node with a 10 ml syringe and 23 gauze needle. The obtained material was spread on the slides and stained with leishman stain and Papanicoloau (PAP) stain. Acid Fast Bacilli (AFB) stain was done for suspected cases of M. tuberculosis infection. Results: The diagnosis based on FNAC procedure were categorized as reactive lymphadenitis (21 cases, 35%), tuberculous lymphadenitis (14 cases, 23.33%), granulomatous lymphadenitis (8 cases, 13.33%), suppurative lymphadentitis (7 cases, 11.66%) and positive for malignancy (3 cases, 5%). The most common diagnosis in the current study of cervical lymphadenopathy was reactive lymphadenitis followed by tuberculous lymphadenitis. Conclusion: FNAC is a quick and reliable method to find the cause of cervical lymphadenopathy allowing appropriate diagnosis, timely management and further investigation if needed.

Kikuchi–Fujimoto disease: A rare cause of cervical lymphadenopathy

Kikuchi–Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare and generally self-limiting disease of uncertain etiology that presents with fever and cervical lymphadenopathy in both the pediatric and adult populations. Here, we present the case of a 5-year-old male who presented with acute onset of fever and cervical lymphadenopathy which was initially diagnosed and managed as staphylococcal lymphadenitis. He underwent an excisional biopsy when symptoms persisted, which confirmed the diagnosis of KFD and was managed conservatively. This case study emphasizes awareness of this entity in the differential diagnosis of fever with persistent lymphadenopathy. Due to its characteristic overlap with other disorders such as tuberculous lymphadenitis, and lymphoma, KFD remains an arduous diagnosis for physicians. Therefore, awareness about its symptoms helps in minimizing potentially harmful unnecessary evaluations and thereby preventing misdiagnosis and inappropriate treatment.

Approach to lymphadenopathy: how to diagnose tuberculosis lymphadenitis

lymphadenopathy is considered as abnormal finding local or generalized that can becaused by neoplasm or infection, as tuberculosis lymphadenitis. Cervical localization has prevalence
 in the variety of disorders, can has a similar kind of clinical presentation and to differentiate them be-comes extremely difficult. We provided a case report of the new onset of extrapulmonary tuberculosis
 lymphadenitis in 42-year-old Indian man. The patient complained of multiply enlarged painful lymphnodes on left anterior neck and was also concerned about sore throat persistent for a year. Objectiveexamination and analysis were without evident inflammatory signs. Previous ultrasound, pulmonaryand abdominal CT-scan investigations also revealed conglomerate of left mediastinal lymph nodes,moderate splenomegaly. The preliminary diagnosis of lymphoma was excluded due to confirmationof typical tuberculosis lymphadenitis with specific testing and morphological changes of the resected
 lymphatic node. Sputum microscopy was found to be negative, which meant that the patient was neg-ative for social transmission of tuberculosis. Affected lymph nodes resolved completely after appro-priate therapy during one-year treatment. This case report of extrapulmonary tuberculosis highlights
 the importance of tissue diagnosis in unclear situations. We used clinical protocol for unspecifiedlymph node enlargement as complete history taking and physical examination that is preliminary fordiagnosis, while laboratory tests, imaging diagnostic methods and tissue samplings are gold standardevaluation for definite lymphadenopathy. Tuberculosis lymphadenitis is popularly known as collarstud abscess and is the most common benign cause of cervical lymphadenopathy in endemic areas.This observation determined the details of the immunocompromised state of the patient, conclusionwas supported by the evidence of Pseudomonas putida associated pharyngitis. The main differentialsigns between lymphoma as immunoproliferative disorder and infectious tuberculosis lymphadenitiswere provided.

Diagnostic Accuracy of Ultrasound to Differentiate Neoplastic and Non-Neoplastic causes of Cervical Lymphadenopathy taking Histopathology as the Gold Standard

Objective: To evaluate the efficacy of high-resolution ultrasound and colour Doppler in differentiating neoplastic and nonneoplastic causes of cervical lymphadenopathy compared to histopathological diagnosis.
 Study Design: Cross-Sectional study.
 Place and Duration of Study: Pakistan Institute of Medical Sciences, Islamabad Pakistan, from Jan to Jun 2019.
 Methodology: The study included 110 patients with palpable cervical lymph nodes undergoing neck ultrasound and Fine needle aspiration cytology/Biopsy. Certain important sonological features were considered to categorize them into nonneoplastic and neoplastic groups. Colour Doppler imaging was employed along with grey-scale imaging. The histopathology results were compared with sonographic findings to determine the diagnostic accuracy of ultrasound in differentiating neoplastic from non-neoplastic causes of enlarged cervical lymph nodes.
 Results: Our study revealed that High-resolution sonography has 94.4% sensitivity and 88.8% specificity, differentiating between neoplastic and non-neoplastic causes of cervical lymphadenopathy. At the same time, the overall accuracy of ultrasound is 90.9%. The most consistent grey-scale feature in the non-neoplastic nodal group was preserved central fatty hilum, while its loss was significantly associated with neoplastic etiologies.Conclusion: Due to high sensitivity and negative predictive value, high-resolution sonography can be deployed as a first-line investigating tool for enlarged lymph nodes, and invasive procedures like Fine needle aspiration cytology (FNAC) can be abandoned in non-neoplastic lymphadenopathies.

Unusual cause of cervical lymphadenopathy in post-partum patient with atypical presentation: Kikuchi disease

Kikuchi-Fujimoto disease, also known as histiocytic necrotising lymphadenitis, is an unusual type of painful lymphadenopathy. It is a self-limiting benign disease; usual management includes supportive therapy. We described a case of Kikuchi Disease in a childbearing-age woman who presented with painless and localised cervical lymphadenopathy during her postpartum period. Histopathology of the affected cervical node reveals areas of apoptosis and necrosis with abundant foamy histiocytes and plasmacytoid monocytes. The cervical node resolves spontaneously, and no subsequent new cervical lymph node was observed in this patient. Patient was given reassurance. It is vital to recognise Kikuchi disease as one of the causes of persistent cervical lymphadenopathy, to provide optimal management and to avoid incorrect treatment.

CASTLEMAN DISEASE : A CASE REPORT OF RARE CAUSE OF CERVICAL LYMPHADENOPATHY

Castleman disease (CD) is a rare lymphoproliferative disorder characterized by enlargement of lymph nodes with two primary subtypes that vary in presentations and course. Unicentric Castleman disease (UCD) presents as a solitary mass, most commonly in the mediastinum, and rarely in the head and neck . In contrast to multicentric Castleman disease (MCD),which features generalized lymphadenopathy and numerous systemic symptoms, a more aggressive clinical course and relatively poorer prognosis .The most common histopathological subtype is the hyaline vascular variant .We present the case of an 14 years old female presented with a slowly expanding painless left sided neck swelling. Physical examination, coagulation tests, infectious disease screening (HIV, HCV and HBsAg), ESR test and chest X-ray were all normal. Both computed tomography (CT) and Ultrasonography (USG) ndings showed a well-dened solid enhancing mass lesion in the left supraclavicular fossa, which was completely excised and diagnosed to have hyaline vascular variant of unicentric Castleman disease .This disorder carries a an excellent prognosis and does not require further therapy if complete excision of the involved lymph node has been done. We report a case of unicentric Castleman disease is a rare cause of cervical lymphadenopathy , diagnosis by excision biopsy and surgical resection is curative. However ,Histopathological examination rules out lymphoma and concluded that it is unicentric Castleman disease, hyaline-vascular variant .

Role of GeneXpert in diagnosis of rifampicin resistant tuberculosis in patients with cervical lymphadenopathy

Tuberculosis is one of the most common causes for cervical lymphadenopathy apart from distant metastasis and lymphoma. Early diagnosis of this disease reduces the patient’s morbidity by initiating early course of Antitubercular treatment with complete resolution of disease. Hence, for diagnosis of this condition we are searching for a modality which can give results in shorter period of time, which is more sensitive, specific and most important easier to perform. Gene Xpert is one such modality which fits into these criteria. In our case series, we are aiming to study the role of Gene Xpert in diagnosis of rifampicin resistant tuberculosis in patients with cervical lymphadenopathy. In our study, excisional biopsy from cervical region was done in 30 cases and were sent for acid fast bacilli culture, Ziehl Neelsen staining and GeneXpert studies, histopathological examination and results were analyzed.

Frequency of Tuberculosis in Cervical Lymphadenopathy at Tertiary Care Hospital

Background: Tuberculosis is a major public health concern, and it is the most prevalent cause of infectious disease that infects the lymphoid tissue of the body. Clinicians have a diagnostic challenge when treating chronic enlargement of cervical lymph node since it may be a sign of a more serious condition. Objective: To assess the frequency of tuberculosis in cervical lymphadenopathy at tertiary care hospital Methodology: This descriptive study was undertaken at the Department of Pulmonology, Fatima Jinnah Institute of Chest Diseases and Sheikh Khalifa Bin Zayyed Al Nahyan Medical Complex Quetta from October 2021 to October 2022. A complete physical examination was performed after taking a detailed medical history from each patient. A pre-designed proforma was used for the collection of all required data. SPSS version 23 was used to analyze all of the data. Results: In the current study, 140 patients were enrolled. There were 84 (60%) male participants while female participants were 56 (40%). The overall frequency of tuberculosis in patients with cervical lymphadenopathy was 98 (70%). Conclusion: Our study concludes that tuberculosis is the prevalent cause of cervical lymphadenopathy. All the patients with cervical lymphadenopathy must be diagnosed for tuberculosis. Keywords: Frequency; tuberculosi; csservical lymphadenopathy

“CERVICAL LYMPHADENOPATHY AND ITS ETIOLOGY IN CHILDREN: A STUDY IN A TERTIARY HEALTH CARE INSTITUTE.”

Background: Lymphadenopathy occurs in a number of cases presenting in ENT out-patient department. Most cases are found to have enlarged cervical lymph glands. Lymphadenopathy is a condition affecting the lymph nodes of the body as a result of infection, benign or malignant conditions. As a result, lymph nodes become enlarged and abnormal in size, shape, consistency and they may show xity, abnormal mobility or symptoms that differ from normal. This is due to uid accumulation and action of lymphocytes. The most common form is lymphadenitis when it is due to inammation. Inammation may spread from surrounding soft tissue via lymphatic vessels or direct involvement of the lymph glands. A study was conducted to have an idea about the most common cause of cervical lymphadenopathy in children as most common region of lymph node in children is cervical groups of lymph nodes. A hospital-based prospective study was Methods and Materials: conducted in the department of otorhinolaryngology and head and neck surgery, from a time period of October 2021 to March 2022 and results analysed from the collected data. Results: Reactive lymphadenopathy due to viral or bacterial infections is the leading cause followed by systemic and malignant diseases. Discussion: Inammatory response is the leading cause of cervical lymphadenopathy in children.

Critical Analysis of Etiopathology of Cervical Lymphadenopathy in patients reporting to the Department of Surgery Chandka Medical College Hospital Larkana

Introduction: Nodes that are aberrant in their size, consistency, or number are referred to as lymphadenopathy. Study Duration: Current research was carried out at Surgery Department of Chandka Medical College (CMC) & Teaching Hospital, Larkana starting from March 2019 to September 2020. Subjects & Methods: After taking written informed consent, 162 patients was included in the study after fulfilling of the inclusion criteria. Chi square test was applied and P-value <0.05 was considered significant Results: The results of reactive/benign in our study were as out of 162 patients 54(33.3%) belongs to positive group and 108(66.7%) belongs to negative group. In tuberculous the frequency distribution results showed that 57(35.2%) positive and 105(64.8%) were negative. In causing factors the results of malignant frequency distribution were as out of 162 patients 51(31.5%) were positive and 111(68.5%) were negative. Conclusion: In conclusion, our study reveals a lower prevalence of malignancy, reactivity, and benign causes of cervical lymphadenopathy, and an increased prevalence of Tuberculosis as a cause of cervical lymphadenopathy in patients presenting to the surgery department at CMC Hospital in Larkana. To avoid lengthy delays in identification and treatment of numerous medical diseases, including potentially curable malignancies, we advocate for conducting biopsy early in the workup of cervical lymphadenopathy. Keywords: Cervical lymphadenopathy, lymphoma, Tuberculous. Etiopathology, Chandka Medical College

A study on cervical lymphadenopathy in a rural based teaching hospital in India

Background: Presence of cervical lymphadenopathy may indicate serious systemic disease process. Proper evaluation of cervical lymphadenopathy is of extreme clinical importance. Aims and Objective: The study objective was to evaluate clinical and demographic profile of cervical lymphadenopathy, to find the etiology, and to study the role of fine-needle aspiration cytology (FNAC) in it’s etiological diagnosis. Materials and Methods: Prospective observational study was carried out in a rural based teaching hospital in India for 1 year. One hundred and twenty-one patients of more than 12 years of age from both genders were included in the study. Detailed history, clinical, blood examination, radiological, microbiological evaluation, and FNAC from lymph node were done for all patients. Excision biopsy was done for selective cases. Results: It was a male predominant study with male: female ratio of 1.12:1 and mean age of the patient was 34.54 years. Cervical lymphadenopathy was mostly unilateral (77.69%) and it was more common in the right side (43.80%). Tuberculosis (TB) (36.37%) was the most common cause of cervical lymphadenopathy in our study followed by reactive hyperplasia of lymph node (23.14%) and metastatic deposit (19%). Among metastatic deposit, 9 (39.13%) had squamous cell carcinoma, 5 (21.74%) had adenocarcinoma, and 1 (4.35%) had small cell carcinoma. Conclusion: TB is the most common cause of cervical lymphadenopathy followed by reactive hyperplasia and metastatic secondary deposit. FNAC is a simple inexpensive relatively painless rapid and reliable method for diagnosis which can be considered as a frontline investigation and can guide requirement for further investigation in the management of cervical lymphadenopathy.

Painless cervical lymphadenopathy in an elderly patient – a rare case of Rosai-Dorfman disease and Hodgkin's lymphoma

Rosai-Dorfman disease (RDD) is a rare, benign disease with extensive lymphadenopathy. In this case, an 81-year-old gentleman with previous pulmonary tuberculosis presented painless cervical lymphadenopathy associated with generalized weakness, loss of appetite, and cough. The causes of cervical lymphadenopathy in the elderly are comprehensive; thorough history, examination, and appropriate investigations are vital in diagnosing diseases. A lymph node biopsy is recommended if blood investigations and imaging are inconclusive. He was later diagnosed with RDD associated with Hodgkin’s lymphoma, and dexamethasone treatment was initiated. Concomitant diagnoses are rare but should not be disregarded. This case report is a reminder that RDD remains a differential diagnosis of cervical lymphadenopathy. Regular monitoring is required as immune dysregulation from the treatment of RDD may exacerbate quiescently treated pulmonary tuberculosis.

Analysis of causes of cervical lymphadenopathy using fine needle aspiration cytology and excision biopsy at tertiary hospital in India

Introduction: The presentation of cervical lymphadenopathy is common, but its diagnosis is sometimes difficult. Fine Needle Aspiration Cytology (FNAC) is a simple, inexpensive, rapid investigative procedure to confirm clinical diagnosis with minimal trauma and low complication rate.Aim: To determine the diagnostic accuracy of FNAC and to correlate diagnosis with FNAC and subsequent histopathological examination of excised biopsy specimens.Materials and Methods: The study was done from data collected from 2013 to 2015. Total 100 Patients with cervical lymphadenopathy were clinically evaluated and FNAC, excision biopsy were done and analysed.Results: FNAC is most sensitive in diagnosing secondary deposits in neck nodes with sensitivity of 88.9%. FNAC is least sensitive in diagnosing lymphomas with sensitivity of 78.6%.FNAC is 100% specific in diagnosing Tubercular lymphadenitis, Lymphomas and secondary deposits in neck nodes. FNAC is 96% specific in diagnosing chronic nonspecific lymphadenitis and 94% specific in diagnosing Reactive changes in cervical lymph node. Overall average sensitivity and specificity of FNAC of cervical lymphadenitis is 65% and 98% respectively.Conclusion: FNAC is a very useful diagnostic tool in patients having significant lymphadenopathy. The metastatic carcinomas, especially squamous cell carcinoma and tuberculous lymphadenopathy can be diagnosed by FNAC with a high degree of accuracy. There is significant limitation in the diagnosis of low grade Non-Hodgkin’s lymphoma from reactive hyperplasia.

Kikuchi’s disease (KD); mimicking malignant lymphoma: A rare cause of cervical lymphadenopathy.

Objective: The aim of this study is to present six cases of cervical lymphadenopathy, diagnosed as Kikuchi’s disease and raise the index of suspicion for this disease. Study Design: Case Series. Setting: Histopathology and Otolaryngology/Head & Neck Surgery Department at Rehman Medical Institute (RMI) Peshawar. Period: July 2016 to March 2021. Material & Methods: Records of patients for cases diagnosed as “histiocytic necrotising lymphadenitis” were retrieved, their corresponding patient files accessed from the archive, and case notes analyzed. Results: In this series, a total of six cases of Kikuchi’s disease are presented. A female predominance is evident from the present data (2:1 female to male ratio). All patients presented with palpable lymph nodes in the neck, predominantly on the left (66.7%). Majority (66.7%) presented with neuralgic pain (on/off). Only one patient did not show weight loss and night sweating, the remaining had all the symptoms. All of the patients recovered spontaneously within 6 months (range 2 to 6 months) with symptomatic treatment for neuralgic pain. Conclusion: Kikuchi’s disease should be kept in the differential diagnosis in young females with persistent neck masses, palpable lymph nodes and suspicious fine needle aspiration cytology (FNAC).

Kikuchi disease: An unusual cause of cervical lymphadenopathy in a young female

Kikuchi-Fujimoto disease (KD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of unilateral cervical lymphadenopathy usually described in adolescents and young adults with female preponderance. Clinically patients present with palpable lymphadenopathy, fever, and loss of weight. Hence, it should be differentiated from other causes of lymphadenopathy such as tuberculosis, lymphoma, or malignancy. Although the majority resolve spontaneously without treatment some may require non-steroidal anti-inflammatory drug or steroids. It may also be associated with systemic lupus erythematosus. Hence early detection, prompt diagnosis, and follow-up of the patient are essential in all cases of unilateral cervical lymphadenopathy in young adults. Here, we describe a 22-year old female who presented with unilateral neck swelling and was clinically diagnosed initially as a case of tuberculous lymphadenitis which on biopsy turned out to be KD.

A Clinico-Pathological Study on Cervical Lymphadenopathy

Background: The analysis of lymph node enlargement in the neck is not an easy task. It is a challenge for surgeon to assess its clinical behaviour and come to a final diagnosis. Those diseases which can be neoplastic also demands correct diagnosis for further management. The study intends to find out systematically the various pathological conditions presenting with enlarged lymph nodes in the neck, also the various modes of clinical presentation and behaviour of these conditions. Relevant investigations have also been studied. Methods: The study population consisted of patients above 12 years presenting with cervical lymph node enlargement. The proforma which was drafted is used. Patient was examined systematically giving utmost importance to local examination. After making a clinical diagnosis, further relevant investigations were done to confirm the diagnosis. Treatment was instituted appropriately and patients were followed up. Results: Majority of the cases in this study had non-neoplastic causes for cervical lymphadenopathy in which tuberculosis is most common. Male to female ratio of 1.38:1 is noted with most cases between 20 and 40 years. Posterior triangle group of lymph nodes was most commonly affected in tuberculosis. In lymphomas level 2 group of lymph nodes is most commonly involved. Variable results were noted among the groups of lesions, with regard to local characteristics like number, laterality, mobility and involvement of other group of lymph nodes, etc. FNAC by virtue of it being inexpensive, quick in getting the results and easy to perform, is one of the important and essential diagnostic procedures. Conclusion: Clinical symptoms in cervical lymphadenopathy is of limited significance because clinical behaviour can be highly variable and mostly non-specific. As cervical lymphadenopathy is an important condition, which always calls for meticulous attention, analysis and treatment. FNAC is found to be a frontline investigation of choice with ......

A case of severe odontogenic infection in Kikuchi‐Fujimoto disease

AbstractKikuchi‐Fujimoto disease (KFD) is a rare cause of cervical lymphadenopathy and is not well understood. We report a case of deep neck space infection arising from a small dentigerous cyst associated with an impacted mandibular third molar in a patient with a recent diagnosis of KFD. We consider the unusual severity of the clinical presentation and suggest that KFD may have a role in the exaggerated response to a minimal dentigerous cyst.

SONOGRAPHIC EVALUATION OF THE CERVICAL LYMPHADENOPATHY WITH PATHOLOGICAL CORRELATION

Background: Enlarged cervical nodes are very common presentation in radiology department. The accurate diagnosis of the cervical lymphadenopathy is very crucial for further management. The aim of this study was to evaluate the cervical lymphadenopathy by sonography and see the effec­tiveness of B mode ultrasound and color Doppler ultrasound in differentiation between the benign and malignant lymph nodes. Methods: A retrospective study was conducted in the Department of Radiology, College of Medical sci­ences, Bharatpur from 2019 to 2021 among 40 patients with clinically palpable cervical nodes. The so­nographic findings and FNAC/biopsy correlation were done with calculation of the p value, sensitivity, specificity, positive and negative predictive values. SPSS 20.0 and Microsoft Excel were used for the data analysis and presentation. Results: Among 40 patients the most common diagnosis was tuberculosis nodes followed by reactive nodes, metastatic nodes and lymphomatous nodes. The sensitivity and specificity for reactive nodes is very high 92% and 89% respectively for B-mode and for color Doppler ultrasound it is 82% and 90%. For TB nodes and metastatic nodes B-mode and color Doppler ultrasound has low sensitivity and high specificity 72% and 71% sensitivity for TB and metastatic nodes respectively and 91% and 94% specificity for TB and metastatic nodes respectively. Conclusions: B mode and color Doppler sonography is very helpful to accurately diagnose the cause of cervical lymphadenopathy with high specificity and sensitivity. However, the differentiation between the tubercular, metastatic and lymphomatous nodes by sonography is very difficult and requires FNAC/biopsy correlation.

Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy

Kikuchi-FujimotoDisease (KFD), also known ashistiocyticnecrotizinglymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosis for physicians. Therefore, one should be made aware of symptoms that can lead to misdiagnosis in patients.