CASTLEMAN DISEASE : A CASE REPORT OF RARE CAUSE OF CERVICAL LYMPHADENOPATHY

Abstract

Castleman disease (CD) is a rare lymphoproliferative disorder characterized by enlargement of lymph nodes with two primary subtypes that vary in presentations and course. Unicentric Castleman disease (UCD) presents as a solitary mass, most commonly in the mediastinum, and rarely in the head and neck . In contrast to multicentric Castleman disease (MCD),which features generalized lymphadenopathy and numerous systemic symptoms, a more aggressive clinical course and relatively poorer prognosis .The most common histopathological subtype is the hyaline vascular variant .We present the case of an 14 years old female presented with a slowly expanding painless left sided neck swelling. Physical examination, coagulation tests, infectious disease screening (HIV, HCV and HBsAg), ESR test and chest X-ray were all normal. Both computed tomography (CT) and Ultrasonography (USG) ndings showed a well-dened solid enhancing mass lesion in the left supraclavicular fossa, which was completely excised and diagnosed to have hyaline vascular variant of unicentric Castleman disease .This disorder carries a an excellent prognosis and does not require further therapy if complete excision of the involved lymph node has been done. We report a case of unicentric Castleman disease is a rare cause of cervical lymphadenopathy , diagnosis by excision biopsy and surgical resection is curative. However ,Histopathological examination rules out lymphoma and concluded that it is unicentric Castleman disease, hyaline-vascular variant .